Search

SF₆ is a potent greenhouse gas, and its current degradation needs harsh conditions and post-treatment. Herein one-step mineralisation at room temp using KOH in water/IPA under UV is shown via acetone-sensitised autocatalysis, yielding sulfite and fluoride.

Smc5/6 association with DNA junctions can support genomic functions. Here, the authors show that Smc5/6 junction polarity preferences, targeting, and dwell times are determined by its structural modules as well as the RPA and PCNA genomic factors.

Insulin signaling plays a crucial role in coordinating skeletal development with whole‑body energy metabolism. Here, the authors use phosphoproteomics to show insulin-signaling rewiring in aged, insulin-resistant bone and identify defective phosphorylation of AFF4 as a key mechanism for regulating gene-specific transcriptional activation.

The development of robust catalysts that could work under high current densities brings promise but is a challenge in CO₂ electroreduction. Here, the authors report a wettability-engineered electrode design for ethylene electrosynthesis that operates over 1000 h without salt precipitation.

A technique called condense-seq has been developed to measure nucleosome condensability and used to show that mononucleosomes contain sufficient information to condense into large-scale compartments without requiring any external factors.

Electrochemical CO₂ reduction to formate with both high catalytic selectivity and stability remains challenging. Here, the authors report high-performance CO₂ electroreduction for molar-scale formate electrosynthesis at kilowatt-scale power by stabilizing bismuth subcarbonate with copper.

N¹-Methylpseudouridine enhances the translation of synthetic mRNAs, independently of innate immunity.

The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD⁺ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and modulated lipid metabolism in vitro and in a mouse hepatic steatosis model.

The widespread emission of sulfur oxide gases from fossil fuel combustion presents major health risks. Here, the authors show that the selective sulfur dioxide capture performance of a metal organic framework is improved by the introduction of missing linker defects and extra-framework barium cations.

Photosystem II drives photosynthesis, but how desert algae adapt to excess of light remains unclear. Here, authors present a cryo-EM structure of PSII from Chlorella ohadii, revealing structural features and antenna arrangements that may contribute to its stability.

Here, Ni-anchored Ru/RuO₂ heterostructure nanosheets serve as CO-tolerant hydrogen oxidation catalyst delivering a peak power density of 1.76 W cm^-2, along with long-term stability in an alkaline exchange membrane fuel cell operating under H₂/Air conditions.

The study used snMultiome-seq to map gene expression and chromatin accessibility in human central amygdala cells from people with and without AUD. Here, the authors show that inhibitory neurons are most affected, with KLF16-driven regulatory changes and AUD-risk variants disrupting gene activity.

Mouse models demonstrate that vagal sensory neurons transmit signals from lung adenocarcinoma to the brain, increasing sympathetic efferent activity in the tumour microenvironment and thereby creating a immunologically permissive environment for tumour growth.

Hepatic glycogenolysis is essential for protein glycosylation and rhythmic secretion by the liver. Disruptions to hepatic glycogenolysis, caused by congenital diseases or physiological factors such as obesity, caloric restriction and changes to meal timing, alter hepatic protein secretion.

While the ligand coordination microenvironment surrounding catalytic centres influences reactivity, dynamic oxygen reconstruction during water oxidation electrocatalysis complicates structure-based mechanistic insights. Now the in situ formation of lattice O–O ligands has been shown to activate Fe centres in metal oxides and hydroxides, thereby enhancing their oxygen evolution reaction activity.

Electron transfer in molecular wires is typically dominated by tunnelling at short lengths. Now it is shown that conjugated molecular wires anchored to indium tin oxide electrodes exhibit a hopping mechanism even at 1-nm lengths, enabling charge extraction in tin perovskite solar cells and improved device performance.

The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

Green hydrogen production via water electrolysis requires a low-cost solution to provide efficient catalysts. Here, the authors report an industrially scalable method for synthesizing NiFe layered double hydroxide at room temperature and atmospheric pressure, enhancing alkaline electrolysis.

Fast charging is driving extensive research on enhanced electrodes for high-performance electrochemical capacitors and micro-supercapacitors. Thick ruthenium nitride pseudocapacitive films are shown to exhibit enhanced capacitance with a time constant of less than 6 s.

Adipose CoA handling is critical for lipid metabolism and homeostasis. Here, the authors identify TMEM120A as an ER-resident CoA binding protein enriched in adipocytes that promotes fatty acid recycling to support energy metabolism and limit lipotoxic stress, while its loss leads to adipose inflammation and metabolic dysfunction under high-fat diet conditions.

Oxygen evolution reaction (OER) catalysts often comprise multiple metal ions in various configurations, hampering mechanistic understanding of how catalysis proceeds. Now, researchers prepare a series of double-atom OER catalysts based on Ni, Fe and Co, which act as molecular-like models and are more amenable to mechanistic study.

Photoreforming can produce H₂ through the simultaneous reduction of water and the oxidation of organic molecules, such as those derived from biomass, but cheaper and more active photocatalysts are required. This study shows that CdS/CdO_x produces H₂ from unprocessed lignocellulose suspensions at high rates under solar illumination.

This report describes a nanobody targeting glycine receptor mGlyR that inhibits its ability to regulate G protein signaling and produces anti-depressant effects in mice providing an immunotherapy approach to potentially treat depression.

This study introduces a sediment-based method to reconstruct Antarctic fast-ice change during the late Holocene, revealing cyclic patterns linked to solar variability and offering insight into long-term cryosphere climate dynamics.

Renewable hydrogen production from water will require understanding and improving the oxygen evolution reaction (OER) on catalyst surfaces. Here, authors report α-Li₂IrO₃ to transform into a hydrated birnessite phase under OER conditions that exhibits enhanced OER performances and durabilities.

Chen et al. show that redox signals activate ADAR1 to fix faulty RNA pieces during DNA copying, ensuring smooth replication and protecting genome stability.

Down syndrome (DS) increases gene dosage that disrupts neurodevelopment and cognition. Using human-derived isogenic neurons, this study reveals altered network activity, synaptic dysfunction, and ion channel defects underlying DS neural impairment.

Coupling a two-step electrochemical system that converts CO₂ to acetate with photovoltaics increases solar-to-food energy conversion efficiency, providing an alternative route to produce food from carbon dioxide and electricity, independent of biological photosynthesis.

Pyramidal neuron-driven mechanisms actively promote the survival and terminal differentiation of their associated interneuron subtypes.

Targeting neurons that regulate energy balance may offer new approaches for obesity treatment. Here, authors show that chemogenetic and pharmacological manipulation of GABAergic neurons in the DRN/vlPAG increases adaptive thermogenesis and reduces weight gain in mice fed a highfat diet.

Highly selective formation of C₂₊ alcohols is obtained using CO electroreduction with a trimetallic-copper-based catalyst incorporating gold nanoparticles and isolated silver atoms.

R2 retrotransposons are natural RNA guided gene insertion systems. Here, Edmonds et al. characterize the structure and biochemistry of an avian R2 and engineer a compact, all-RNA system to integrate DNA in mammalian cells, aiding the development of future retrotransposon-based gene editors.

5-Deoxyribose is formed from 5′-deoxyadenosine, a toxic byproduct of radical S-adenosylmethionine enzymes. Here, the authors identify and biochemically characterize a bacterial salvage pathway for 5-deoxyribose, consisting of three enzymes, and solve the crystal structure of the key aldolase.

Understanding the mechanisms underlying the survival of drug tolerant persister cells following chemotherapy remains elusive. Here, multi-omics analysis and experimental approaches show that the germ-cell-specific H3K4 methyltransferase PRDM9 promotes metabolic rewiring in glioblastoma stem cells.

Anion-exchange membrane water electrolysers have the potential to rival more costly acidic proton-exchange membrane electrolysers, but their performance and efficiency commonly still fall short. Now an anion-exchange membrane water electrolyser is prepared with a NiFe layered double hydroxide catalyst-coated membrane that achieves high current densities above 2 A cm⁻² at 1.8 V and operando X-ray absorption spectroscopy is used to track the formation of the catalytically active γ-LDH phase.

Aqueous organic redox-flow batteries are known to suffer capacity loss via degradation of the redox-active species. Here, the authors use in situ methods to study the electrolyte flavin mononucleotide, identifying a redox mediator mechanism that mitigates capacity loss and a route to prevent its degradation.

The cryo-electron microscopy structure of the mitochondrial TIM23 complex from Saccharomyces cerevisiae shows that Tim17 forms a protein translocation path.

Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.

Cell surface receptors perceive immunogenic elicitors, triggering downstream signalling via receptor-like cytoplasmic kinases such as BIK1. Here the authors define and use the phosphorylation motif of BIK1 to find novel substrate candidates.

Fe-based oxyhydroxides are promising catalysts for oxygen evolution reactions. However, the dynamics of Fe sites require further investigation. Here, the authors report Fe oxyhydroxide clusters on nickel or cobalt oxyhydroxides as key active sites for water oxidation and reveal how these clusters are selectively formed under controlled electrochemical conditions.

Vertebra lengths differ from the neck to the tail tip and differ between species, evidenced by extreme differences in mouse and jerboa tails. Here, Weber and colleagues identify cellular mechanisms and candidate genes that shape vertebral proportion.

Heterometallic nanomaterials in unusual crystal phases that are impossible to form in the bulk state can show interesting physical and chemical properties. Here, crystal-phase heterostructured 4H/fcc Au nanowires are used as seeds to epitaxially grow a variety of binary and ternary hybrid noble metal nanostructures on the phase boundary.

Here the authors show that mitochondrial RNA leaks into the cytosol of senescent cells through sublethal apoptosis, driving inflammation. Blocking this pathway improves outcomes in Metabolic Dysfunction-Associated Steatohepatitis.

High-entropy alloys are promising electrocatalysts for multistep and tandem reactions, yet its mechanism remains unclear. Here, the authors address this challenge by using in-situ XAS to reveal the multi-site hydrogen evolution mechanisms on high-entropy metallenes in wide pH electrolytes.

How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thiodG) targets telomerase to inhibit telomere maintenance in cancer cells and tumors was unclear. Here, the authors show that telomere length and telomerase status determine 6-thio-dG sensitivity and uncover the molecular mechanism by which 6-thio-dG selectively inhibits telomerase synthesis of telomeric DNA.

Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arrest and block phage dissemination.

A cavity-array microscope is realized using intra-cavity lenses to create a two-dimensional array of over 40 modes, each coupled to a single atom in free-space.

Biochemical and structural studies of the human MCM replicative DNA helicase complex show differences from the yeast complex and provide insights into mechanisms of double hexamer assembly on sequence-independent replication origins.