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Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial

Evidence for the treatment of patients with mild-to-moderate COPD is limited. Here, the authors show that long-term treatment with high-dose N-acetylcysteine neither significantly reduced the annual rate of total exacerbations nor improve lung function in patients with mild-tomoderate COPD.

Yumin Zhou
Fan Wu
Li Chen
ResearchOpen Access30 Sept 2024
Nature Communications

Volume: 15, P: 1-11
High temperature shockwave stabilized single atoms

A repeated on–off high-temperature shockwave is shown to be a generalizable way of efficiently synthesizing and stabilizing single atoms at high temperatures.

Yonggang Yao
Zhennan Huang
Liangbing Hu
Research12 Aug 2019
Nature Nanotechnology

Volume: 14, P: 851-857
Relationship between childhood socio-economic status and wellness tourism intention: a combined PLS-SEM and NCA methods

Junxian Shen
Hongfeng Zhang
Lianping Ren
ResearchOpen Access13 Jun 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-12
Sphingosine kinase 2 deficiency impairs VLDL secretion by inhibiting mTORC2 phosphorylation and activating chaperone-mediated autophagy

Shuangshuang Zhang
Gaoxiang Li
Hong Zhou
ResearchOpen Access08 Apr 2025
Cell Death & Differentiation

Volume: 32, P: 1886-1899
Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis

Preclinical studies suggest that the lymphatic system has a critical role in the pathogenesis and therapy of inflammatory-erosive arthritis. These findings, and complementary data from human studies, highlight the translational potential of assessing and modulating the lymphatic system in patients with chronic arthritis.

Echoe M. Bouta
Richard D. Bell
Edward M. Schwarz
Reviews11 Jan 2018
Nature Reviews Rheumatology

Volume: 14, P: 94-106
SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition

Longjun Li
Haitao Wang
Hong Zhou
Research11 Dec 2019
Cell Death & Differentiation

Volume: 27, P: 1924-1937

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Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial

High temperature shockwave stabilized single atoms

Relationship between childhood socio-economic status and wellness tourism intention: a combined PLS-SEM and NCA methods

Sphingosine kinase 2 deficiency impairs VLDL secretion by inhibiting mTORC2 phosphorylation and activating chaperone-mediated autophagy

Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis

SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition

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