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The authors reveal that even within a few-nanometre thin films, ultrafast all-optical magnetisation switching is spatially inhomogeneous along the depth and driven by the picosecond propagation of a transient domain boundary.

Optical aberrations in Structured Illumination Microscopy (SIM) can lead to loss of resolution and artifacts making it unsuitable for thick samples. Here the authors combine Adaptive Optics and SIM (AO-3DSIM) to improve the 3D resolution and reduce artifacts, performing 3D-SIM in C.elegans.

Intensity adaptive optics employs a dual-feedback loop to recover non-uniform intensity distribution and energy loss at the pupil plane, validated in both sensor-based and sensorless formats.

Retarder arrays enable advanced photonic applications but are limited by controllable flexibility. Here, authors demonstrate a compound modulator that creates synthetic tuneable retarder arrays, offering unprecedented dynamic control of light, enabling new beam generation, analysis, and correction.

E. coli sequence type 131 is a significant cause of community-onset infection. Here, the authors perform a prospective household-based cohort study in Singapore including samples from humans, companion animals, the environment, and food, to characterise transmission and carriage dynamics.

Phosphorus is an essential plant nutrient. Here Meng et al. show that low phosphorus availability stimulates hydrogen peroxide production which in turn promotes the oligomerization, nuclear translocation and DNA binding activity of the PHR2 transcription factor and enhances the phosphate starvation response.

MoS₂ is an attractive lubricant for space-based applications, yet suffers from degradation by atomic oxygen in low Earth orbit. Here, a MoS₂/W multilayer film exhibits oxidation resistance and sustained super lubricity, offering a lubrication solution for aerospace applications.

This study introduces the Cattle Cell Atlas, a single-cell expression resource including 1,793,854 cells from 59 tissues. Integrative analyses leveraging this atlas provide insights into the biology underlying bovine monogenic and complex traits.

Solid-state optical beam steering is crucial for a wide array of optical technologies. Here, the authors present a chip-scale multi-beam steering system using an acousto-optic array. Each beam is individually controllable, enabling simultaneous transmission of multiple data streams to multiple receivers for advanced free-space optical communication.

An automated perfusable microfluidic bioreactor can generate clinical doses of viable CAR T cells that are functionally comparable to cells produced in standard open-culture systems.

Using Kepler, this study identifies a compact multiplanetary system that is not flat, where gravitational interactions cause its planets’ periods to change by nearly a day per cycle and their orbital planes to tilt back and forth.

The RNA editing enzyme ADAR1 blocks interferon responses triggered by cytosolic RNA sensors, and has been proposed as a potential target in immuno-oncology. Here, the authors report that BRCA1/2 and ADAR1 are synthetic lethal, showing that ADAR1 depletion in BRCA1-mutant cells causes autocrine interferon poisoning

The vast amount of uranium in seawater is driving a shift from the use of mined ore to seawater extraction. Here the authors describe an adsorbent design based on polymers of intrinsic microporosity that adopts a bioinspired structure and allows efficient uranium capture.

XBB is the first recombinant, globally dominant variant of SARS-CoV-2. Here, the authors examine the variant’s origins and virological properties, showing it is the first example of SARS-CoV-2 improving its fitness through recombination.

Protonic ceramic electrochemical cells (PCECs) interconvert hydrogen and electricity and therefore have potential as long-duration energy storage systems, but the durability of these devices under industrially relevant conditions is limited. Here the authors report a PCEC that maintains low degradation rates throughout exceptionally long-term durability tests.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

This study reveals that CYBDOM proteins promote drought tolerance by regenerating apoplastic ascorbic acid (AsA) and activating autophagy through interaction with RbohD, and link AsA redox, ROS and selective autophagy in plant stress responses

Recent Omicron SARS-CoV-2 subvariants independently acquire 5 key Spike mutations. Here, the authors evaluate the evolutionary importance of the 5 mutations and characterize the virological properties of variant BQ.1.1 harboring all 5 mutations.

DeepFlow uses deep learning to extract cardiac flow phenotypes from phase-contrast magnetic resonance images. Genome-wide analyses of cardiac flow traits in UK Biobank highlight the contribution of connective tissue genes to aortic valve function.

Photonic synthetic dimension (on TFLN chip) attracts broad interest. Here, authors achieve tunable couplings via MZI-linked resonators, and prove its versatility by realizing multiple models including tight-binding lattice, the Hall ladder and Creutz ladder along with their featured phenomena

All-optical switching of magnetization refers to the process whereby an optical pulse is used to reverse the magnetization of a magnetic system. In a small subset of magnetic materials, this process can occur with a single optical pulse, known as single-shot all optical switching, enabling fast operations. Here, Peng et al show that this process can occur for a wide variety of rare earth–transition metal multilayers, expanding the range of potential materials that can exhibit this effect.

Hydrogel materials have emerged as versatile platforms for biomedical applications. Here this group reports an mRNA lipid nanoparticle-incorporated microgel matrix for immune cell recruitment/antigen expression and presentation/cellular interaction thereby eliciting antitumor efficacy with a single dose.

Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here, the authors generate single-drug nanoparticles by hybridising lysomotropic detergents and the bisaminoquinoline-based autophagy inhibitor, and show their therapeutic potential as autophagy-inhibition based combination therapy.

Cancer cells exploit altered metabolic pathways to dynamically regulate epigenetic methylations. Here, the authors show the canonical metabolic and nonmetabolic functions of PRPS2 in enhancing ATP utilization and SAM biosynthesis, promoting RNA m⁶A methylation for lung tumorigenesis and metastasis.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

An alternative route to drive the transverse optical phonon softening sheds light on developing a unified theory for ferroelectricity enhancement in ultrathin films free from depolarization fields using ionic radius differences and strains, among other methods.

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory respiratory disease characterized by airflow limitation and infective exacerbations. Here, Chan et al. report the generation of nasopharyngeal and bronchial COPD organoids derived from adult stem cells and employ them in the study of host-pathogen interactions, including SARS-CoV-2 and Pseudomonas aeruginosa.

The GRIN lenses widely used for deep brain functional imaging suffer from a small measurement field of view due to strong fourth-order astigmatism. Here the authors report Geometric Transformation Adaptive Optics (GTAO) that corrects field-dependent astigmatism and enables large-volume in vivo imaging of deep mouse brain through 0.5 mm GRIN lenses.

Defect engineering of 2 dimensional layered double hydroxide sheets improves their photocatalytic activity. Here, the authors etch sheets in acid and show that the etched sheets generate substantially more reactive oxygen species that untreated sheets and the treated sheets can be used to kill cancer cells in vitro and in vivo.

Addressing the stability challenges from metal electrodes/perovskite components chemical interactions is essential for high-performance perovskite solar cells. Here, authors design a bilayer polymer buffer to mitigate metal/ion interdiffusion, realizing a certified efficiency of 26.46%.

The role of eiptranscriptomic modifications in autophagy is unclear. Here, the authors show that the m⁶A reader YTHDF3 functions as a nutrient responder to recognize upregulated m⁶A modification, promoting FOXO3 translation to subsequently initiate autophagy.