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Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Persistent microglial activation upon ischaemic injury leads to the formation of stroke-associated foamy microglia, perpetuating long-term inflammation, white matter damage and functional impairments. These effects can be ameliorated by reducing microglial cholesterol overload through activation of CYP46A1.

Liver proteome dysregulation contributes to the development of alcohol-associated liver disease (ALD), a major global health challenge. Here, the authors develop an approach to specifically identify the liver nascent proteome under various physiological and pathological conditions, revealing key regulators involved in hepatic steatosis.

Novel methodologies for cleaving inherently inert C(sp²)‒ C(sp²) bonds are desirable. Here, the authors report the use of an oriented electric field to cleave C(sp²)‒ C(sp²) in cycloparaphenylenes via electrophilic aromatic substitution.

The authors synthesize intrinsic room-temperature ferroelectric CuVP₂S₆ via spatially confined chemical vapor deposition method, uncovering the ferroelectric mechanism, which originates from the movement of Cu ions.

Previous hypotheses cannot fully explain the large lightning excess over land compared to ocean. It is found that coarse sea spray that create large drops precipitates cloud water before it can freeze, thus robbing the fuel for cloud electrification

Proteome profiling of plasma samples in human pan-cancer cohorts reveals patterns of biomarkers for diagnosis.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Though charge transport in molecular devices depend on the electrode-molecule interface, controlling the interface’s contact geometry remains a challenge. Here, the authors report molecular junctions featuring TTF-fused NDI molecules anchored to gold electrodes through direct TTF-Au contacts.

Rat hepatitis E virus (HEV) can infect humans, but the extent of spillover isn’t well studied. Here the authors develop a serological test that distinguishes exposure to rat HEV from other HEV infection and show substantial spillover in a biodiversity hotspot in China. The method can support surveillance of rat HEV.

Strong magnetic interfacial coupling in van der Waals heterostructures provides a new platform for discovering novel physics and effects. Here, the authors report the formation of skyrmion lattice in the WTe₂/Fe₃GeTe₂ van der Waals heterostructure and a Dzyaloshinskii–Moriya interaction with a large energy density of 1.0 mJm⁻².

The CAPItello-291 phase 3 study reported that capivasertib (an AKT inhibitor) and fulvestrant (a selective estrogen receptor degrader) improved progression free survival in patients with HR-positive/HER2-negative advanced breast cancer. Here, the authors report the results of an extended Chinese cohort recruited as part of the original global CAPItello-291 study.

Wang et al. reveal that epigenetic changes driven by zinc finger MYND-type containing 8 promote the transition from adenocarcinoma to antiandrogen-resistant neuroendocrine prostate cancer and offer a therapeutic approach by targeting the histone reader with a small molecule.

A versatile hydrothermal approach in an operando acidic environment created ferromagnetic single-atom spin catalysts (SASCs). Ni-based SASC exhibits a giant magnetic field enhancement of OER activity, boosting both water and saline water electrolysis.

The collision of the Indian, Arabian and Eurasian plates formed the Tibetan and Iranian plateaus, but its timing and processes remain debated. This Review explores the evidence behind initial collision estimates and discusses the tectonic and geodynamic implications.

Analyses of whole-genome sequencing data in children and validation in mouse models show that offspring born from blastocyst-stage embryo transfer have shorter leukocyte telomere lengths.

The dissatisfied delivery efficiency of drugs to lungs and other metastatic sites limit the corresponding therapeutic efficacy. Here this group reports an inhalable surfactant-based nanoliposome system to co-deliver Osimertinib and DNA plasmid which is capable of fusing into pulmonary surfactant, penetrating through physiological barriers and targeted accumulating in lung tissues.

De-Chen Lin and colleagues report whole-exome sequencing, targeted sequencing and SNP array analysis of 128 cases of nasopharyngeal carcinoma (NPC), a tumor type connected to Epstein-Barr virus infection. Their results identify a distinct mutational signature with nine significantly mutated genes and mutations enriched in cellular processes, including chromatin modification and autophagy.

The intrinsic Kerr nonlinearity in ring resonators is exploited to demonstrate passive isolation of a continuous-wave laser. Up to 35-dB isolation with 5-dB insertion loss was achieved on-chip.

In this prespecified analysis of the ongoing TORCHLIGHT phase 3 trial, first-line treatment with toripalimab and nab-paclitaxel in patients with advanced triple-negative breast cancer led to significantly longer progression-free survival in the PD-L1-positive population compared to nab-paclitaxel alone.

Controlling the structural transformations of metal clusters is challenging. Here, the authors synthesize a silver nanocluster and study the structural changes that take place upon reaction with bipyridine derivatives.

Genome-wide profiling of chromatin accessibility by DNase-seq or ATAC-seq has been widely used to identify regulatory DNA elements and transcription factor binding sites. Here the authors develop a computational model, SELMA, to estimate and correct enzymatic cleavage biases in chromatin accessibility profiling data.

Dual blockade therapy is currently being trialled for multiple tumour types, but efficacy is variable. Here, the authors use longitudinal proteomics profiling of 22 patients to develop a predictive model of therapy response.

Genome-wide siRNA screens identify an essential function for sorting nexin 5 in virus-induced autophagy and immunity mediated via class III phosphatidylinositol-3-kinase complex 1.

Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

The authors demonstrate a multi-dimensional communication scheme that combines wavelength- and mode- multiplexing on photonic integrated circuits using foundry-compatible photonic inverse design and spectrally flattened microcombs

Biocompatible afterglow materials have potential in imaging applications, but are challenging to prepare. Here the authors report the development of carbon nanodots with near-infrared afterglow, and demonstrate their use in imaging for tumour resection.

In this paper, the authors discovered and validated aminoacylated lysine ubiquitination and its writer using the genetic code expansion strategy. This non-lysine ubiquitination assembled by UBE2W can mediate rapid protein and proteome degradation.

Ovarian cancer is common among women and is the leading cause of death from gynaecological malignancies. Here the authors identify two previously unknown genetic variants that increase the risk of epithelial ovarian cancer in Han Chinese women.

To prevent charge losses and degradation at the buried interface of inverted methylammonium-free perovskite solar cells, Li et al. form a 2D/3D perovskite structure using 2-aminoindan hydrochloride as an additive.

Inorganic nanoparticles can accumulate in living organisms causing a dose-dependent increase in cellular reactive oxygen species. Here, the authors leverage this as a potential scheme for regulating metabolic disorders, showing that that low-dose nanoparticle administration can enhance lipid hydrolysis and alleviate fatty liver.

Fatigue-resistant adhesion is of interest for a range of applications, but has been limited in synthetic hydrogels. Here, the authors report on a synthetic hydrogel with ordered nanocrystalline domains resulting in high fatigue-resistant adhesion and demonstrate the coating of different surfaces.

Maan et al., Meier et al. and Song et al. report that microtubule plus-tip end binding proteins can undergo liquid–liquid phase separation and regulate microtubule dynamics.

Although continuous monitoring of tissue oxygenation is critically important after tissue/organ graft procedures, current technologies have key limitations. Here, the authors develop a miniaturized, minimally invasive, self-anchoring optical probe and demonstrate continuous monitoring of oxygenation in porcine flap and organ models.

Copper nanoclusters have so far been limited in the types of organic transformations they can catalyze. Here the authors introduce a new NIR-II emissive anionic copper nanocluster with intrinsic photoredox activity, enabling efficient photocatalytic three-component radical couplings.

In this paper, the authors report the directed-evolution of translation systems that allow the incorporation of unnatural amino acids with similar efficiency to natural amino acids and the construction of synthetic auxotroph in a generalizable way.

Abnormal placentation is associated with recurrent spontaneous abortion (RSA) risk. Here the authors report that low embryonic villous succinate level associates with risk of RSA in patients, and increasing succinate levels is sufficient to reduce the incidence rate in a mouse model of spontaneous abortion.