Lopez Zapana, DeBolt et al. apply untargeted proteomics to identify second trimester molecular signatures of spontaneous and medically-indicated preterm birth and assess how BMI shapes these patterns. Distinct proteomic profiles define each subtype, and BMI strongly modifies inflammatory and metabolic pathways linked to preterm birth.
- Paola A. Lopez Zapana
- Chelsea A. DeBolt
- Douglas A. Lauffenburger