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Liquid–liquid phase separation of the endoplasmic reticulum (ER)-resident protein PDZD8 leads to the formation of biomolecular condensates that stabilize ER–mitochondria contact sites.

The transmembrane protein lunpark is enriched at endoplasmic reticulum junctions where it acts as an organization hub, integrating translation initiation control with nutrient sensing through association with lysosomes.

A study finds that mechanical activation leads to microtubule rearrangement, facilitating the proteasomal degradation of an inhibitor of YAP/TAZ, thus promoting YAP/TAZ nuclear translocation.

Paul et al. demonstrate that entry into the cell cycle from quiescence involves a transient, partial inactivation of the APC/C ubiquitin ligase, which halts the degradation of glycolysis enzymes and ensures sufficient ATP production for cell division.

Kleptosomes are specialized organelles harbouring photosynthetically active chloroplasts that are taken up by so-called ‘solar-powered’ sea slugs.

The authors of a new study characterize blebbisomes, large extracellular vesicles that contain functional mitochondria and other organelles and have significant roles in inter-cellular communication and the tumour microenvironment.

Subunits of mitochondrial and cytosolic ribosomes need to be targeted to their correction cellular location. A study identified a mitochondrial avoidance segment in a eukaryotic cytosolic ribosome subunit that prevents its mislocalization to mitochondria.

This study uncovered how extracellular vesicles carrying gasdermin D pores propagate pyroptosis between cells, exacerbating inflammation.

The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. describe a novel assembly factor that evolved during the terrestrialization of land plants.

Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in the zebrafish embryo, enabling the transport of proteins and organelles.

Rapid reactivation of gene expression following mitosis-induced silencing is facilitated by a network of redundantly acting nuclear receptors that function as mitotic bookmarks.

A new biotinylation-based approach identifies previously unknown cell surface proteins of the axonal initial segment (AIS) and shows a role for contactin-1 in assembly of the AIS extracellular matrix.

A study analyses the nanotopography of presynaptic calcium channels and release sensors and the degree of their coupling during maturation of an inhibitory synapse.

Cytoplasmic mislocalization of TDP-43 in neurodegenerative disease affects mRNA maturation and protein levels of stathmin-2, leading to a reduction in axon diameter and tearing of outer myelin layers and thereby disrupting neuronal function.

Farmer et al. show that mRNAs encoding abscission proteins are targeted to the midbody during cell division and are locally translated to enable cytokinesis.

Evidence mounts that these peptides are the key component of plaques associated with Alzheimer’s and might give rise to the disease.

Scott et al. describe a mechanism based on C-degron mimicry by which an E3 ubiquitin ligase discriminates bona fide substrates from non-physiological substrates.

Cycles of stretch and compression, such as during cell migration through tissues, lead to stabilization of microtubules owing to redistribution of the plus-end-binding protein CLASP2 along microtubule lengths.

McCarthy et al. identify distinct populations of smooth muscle cells in the intestine that support the establishment of the intestinal stem cell niche during postnatal development by supplying trophic signals to enable niche expansion.

To activate noncanonical LC3B lipidation and NLRP3 inflammasome formation, stimulator of interferon genes (STING) forms a proton channel in Golgi membranes.

Yang, Zhu et al. describe temperature-dependent structural conformations of COOLAIR lncRNA and their impact on flowering time.

Cockburn et al. report that cells exiting the epidermal stem cell layer show a gradual progression of transcriptional changes during differentiation and retain the ability to divide once differentiation-committed.

Tan and Finkel report a novel phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway that is crucial for lysosome membrane repair.

Fong et al. describe a novel complex that links between H3K9 methylation and H3K27 methylation and has a role in gene silencing and cancer.

Kirova et al. demonstrate that reactive oxygen species signals are integrated into cell cycle control through a direct interaction with cyclin-dependent kinase 2.

Zhang et al. show that in fungal and plant cells CO₂ sensing involves liquid–liquid phase separation of PP2C phosphatases.

Adequate levels of nucleotides are essential to ensure genetic stability of proliferating cells. A study finds gap-junction-mediated transport of nucleotides in specific tissues of Drosophila.

In a recent study, Bong et al. identify a polarized distribution of contact sites between the endoplasmic reticulum and plasma membrane in migrating cells, whereby higher density of contacts in the back of the cells prevents the formation of additional migration fronts.

Zhao et al. describe how nuclear deformation during confined cell migration affects chromatin organization and biomolecular condensates. Chromatin heterogeneity in the trailing nuclear half creates a permissive environment for condensate formation, with potential roles in nuclear mechanics and chromatin interactions.

De Caestecker and Macara find that the sorting of membrane proteins in the Golgi relies on a size filter that enables correct localization of proteins with a short cytosolic domain to the apical membrane.

This study finds that microtubules act as a mechanostat during cell migration, becoming mechanically reinforced in response to compression to protect the nucleus and coordinate contractility.

Kawaguchi et al. identify a chromatin code based on repressive histone 3 lysine 27 trimethylation (H3K27me3) that serves as a segment-specific positional marker in connective tissue cells of axolotls, enabling correct patterning during limb regeneration.

Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosis following bacterial infection.

Sarkar et al. identify a feedback loop between the methyltransferase SETDB1 and nuclear pore complexes that ensures silencing of early-oogenesis genes as oocyte specification progresses.

The eukaryotic genome is organized into topologically associating domains by cohesin and CTCF. Davidson et al. now reveal a role for DNA tension in the regulation of the CTCF–cohesin interaction to modulate domain boundaries.

The tight junction protein TJP1 is essential for controlling BMP signalling during patterning of human gastrulation models.

Transport of the developmental mRNA oskar to its destination at the posterior pole of the Drosophila embryo relies on the two dsRNA-binding proteins Egalitarian and Staufen that promote switching between the motor proteins dynein and kinesin.

Malka et al. uncover thousands of 5′ uncapped and polyadenylated transcripts (5′ UPTs) and describe their biogenesis through the alternative polyadenylation pathway. 5′ UPTs contribute to the proteome as non-canonical peptides with likely diverse biological functions.

Organelles are normally transmitted to progeny exclusively through the maternal germ line. Chung et al. now describe genetic and environmental factors that increase the inheritance of plastids through pollen.