Nature Search

Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

Volume: 28, P: 1393-1403
Involvement of the oxygen minimum in benthic zonation on a deep seamount

Karen Wishner
Lisa Levin
Lauren Mullineaux
Research05 Jul 1990
Nature

Volume: 346, P: 57-59
Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses

Lisa Chakrabarti
Mireille Guyader
Pierre Sonigo
Research06 Aug 1987
Nature

Volume: 328, P: 543-547
Seeds and the city: a review of municipal home food gardening programs in Canada in response to the COVID-19 pandemic

Janet Music
Lisa Mullins
Kydra Mayhew
ResearchOpen Access17 Aug 2022
Humanities and Social Sciences Communications

Volume: 9, P: 1-12
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Sarah M. C. Colbert
Eric T. Monson
Lea Zillich
ReviewsOpen Access25 Sept 2025
Molecular Psychiatry

P: 1-11
HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

Suppressive combination antiretroviral therapy fails to eradicate HIV-1 latent reservoirs in poorly characterized cell compartments. Here, urethral macrophages, but not urethral T cells, are shown to contain integrated HIV-1 DNA and to be able to release infectious HIV-1 following reactivation with lipopolysaccharide.

Yonatan Ganor
Fernando Real
Morgane Bomsel
Research04 Feb 2019
Nature Microbiology

Volume: 4, P: 633-644
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
Identification of an intronic single nucleotide polymorphism leading to allele dropout during validation of a CDH1 sequencing assay: implications for designing polymerase chain reaction-based assays

Franklin M Mullins
Lisa Dietz
Iris Schrijver
Research01 Nov 2007
Genetics in Medicine

Volume: 9, P: 752-760
Salt-responsive gut commensal modulates T_H17 axis and disease

High salt intake changed the gut microbiome and increased T_H17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of T_H17 cells and increased blood pressure in humans.

Nicola Wilck
Mariana G. Matus
Dominik N. Müller
Research15 Nov 2017
Nature

Volume: 551, P: 585-589
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-16
The mode of action of plant associated Burkholderia against grey mould disease in grapevine revealed through traits and genomic analyses

Qassim Esmaeel
Cédric Jacquard
Essaid Ait Barka
ResearchOpen Access10 Nov 2020
Scientific Reports

Volume: 10, P: 1-14
YY1^lo NKT cells are dedicated IL-10 producers

Patrick W. Darcy
Lisa K. Denzin
Derek B. Sant’Angelo
ResearchOpen Access03 Mar 2020
Scientific Reports

Volume: 10, P: 1-15
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Altered 5-HT_2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Ursula F Bailer
Julie C Price
Walter H Kaye
Research31 Mar 2004
Neuropsychopharmacology

Volume: 29, P: 1143-1155
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

Simone de Jong
Mateus Jose Abdalla Diniz
Gerome Breen
ResearchOpen Access08 Oct 2018
Communications Biology

Volume: 1, P: 1-10
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Amendments and Corrections18 May 2020
Molecular Psychiatry

Volume: 26, P: 5465

Search

Genomics yields biological and phenotypic insights into bipolar disorder

Fine-mapping genomic loci refines bipolar disorder risk genes

Involvement of the oxygen minimum in benthic zonation on a deep seamount

Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses

Seeds and the city: a review of municipal home food gardening programs in Canada in response to the COVID-19 pandemic

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

Genome-wide association study identifies 30 loci associated with bipolar disorder

Identification of an intronic single nucleotide polymorphism leading to allele dropout during validation of a CDH1 sequencing assay: implications for designing polymerase chain reaction-based assays

Salt-responsive gut commensal modulates T_H17 axis and disease

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

The mode of action of plant associated Burkholderia against grey mould disease in grapevine revealed through traits and genomic analyses

YY1^lo NKT cells are dedicated IL-10 producers

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Altered 5-HT_2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Search

Quick links

Search

Filter By:

Search

Quick links