This study reports that m6A on retrotransposon RNAs is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance H3 K9 dimethylation and H3 K27 monomethylation at specific sites, thereby leading to closed heterochromatin states and transcriptional silencing.
- Peizhe Song
- Zhihe Cai
- Guifang Jia