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Showing 101–150 of 1357 results
Advanced filters: Author: Long Zhao Clear advanced filters
  • Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

    • Marta Paczkowska
    • Jonathan Barenboim
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • A new study reconstructs eight-century streamflow over the South and East Tibetan Plateau, showing that observations underestimate the full range of long-term streamflow variability and revealing contrasting regional variability in streamflow between south and north study regions.

    • Yenan Wu
    • Di Long
    • Chunhong Hu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13
  • Measurements of the proton’s spin structure in experiments scattering a polarized electron beam off polarized protons in regions of low momentum transfer squared test predictions from chiral effective field theory of the strong interaction.

    • X. Zheng
    • A. Deur
    • Z. W. Zhao
    Research
    Nature Physics
    Volume: 17, P: 736-741
  • Helicobacter pylori (H. pylori) establishes chronic infection in human, but the underlying mechanistic insights are lacking. Here the authors use single cell RNA and TCR sequencing to profile peripheral blood and mucosal cells from infected patients to report alterations in macrophage differentiation and T cell gene signature that may contribute to persisting H. pylori infection.

    • Wei Hu
    • Ze Min Chen
    • Wei Gong
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • A simple and versatile strategy is established to facilitate molecular recognition by extending electron catalysis for use in supramolecular non-covalent chemistry.

    • Yang Jiao
    • Yunyan Qiu
    • J. Fraser Stoddart
    Research
    Nature
    Volume: 603, P: 265-270
  • The discovery of superconductivity in hydrides at critical temperature (Tc) near room temperature receives intensive attentions. Here the authors report experimental synthesis and discovery of superconductivity with Tc above 210 K in calcium superhydrides at 160–190 GPa.

    • Zhiwen Li
    • Xin He
    • Changqing Jin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-5
  • Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb−1.

    • G. Aad
    • B. Abbott
    • L. Zwalinski
    ResearchOpen Access
    Nature
    Volume: 633, P: 542-547
  • This study measured urban moist heating rates in more than 2,300 cities in the Global South between 2003 and 2020 with a new dataset. It found an increase in urban moist heat of 0.41 ± 0.01 °C per decade, exacerbated by urban browning by 0.05 °C per decade in cities such as those in Nigeria.

    • Huilin Du
    • Wenfeng Zhan
    • Manchun Li
    Research
    Nature Cities
    Volume: 2, P: 157-169
  • Circularly polarized luminescence in solution offers several advantages, however, it remains challenging for organic molecules to achieve circularly polarized luminescence with high dissymmetry factors in solutions. Here, the authors report a strategy using chiral liquid crystals to achieve circularly polarized luminescence with high dissymmetry factors for achiral organic molecules in solutions.

    • Ming-Jun Ji
    • Wen-Long Zhao
    • Chuan-Feng Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

    • Yilong Li
    • Nicola D. Roberts
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 112-121
  • The early signalling events following ethylene perception by plants remain incompletely understood. Here the authors show that in the absence of ethylene, rice MHZ3, a known stabilizer of OsEIN2, promotes phosphorylation of OsCTR2 to suppress ethylene signalling.

    • Xin-Kai Li
    • Yi-Hua Huang
    • Jin-Song Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14
  • Li–O2 batteries suffer from poor charge transport in the insulating discharge products. Here the authors tackle the issue by pre-depositing a K2CO3 layer and then using this to grow Li2O2 film on top, enabling enhanced electronic conduction properties and improved overall performance.

    • Shu-Mao Xu
    • Xiao Liang
    • Jie-Sheng Chen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10
  • East Asia contains “relict” plant species that persist under narrow climatic conditions after once having wider distributions. Here, using distribution records coupled with ecological niche models, the authors identify long-term stable refugia possessing past, current and future climatic suitability favoring ancient plant lineages.

    • Cindy Q. Tang
    • Tetsuya Matsui
    • Jordi López-Pujol
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14
  • Succinylation of PD-L1 by carnitine palmitoyltransferase 1A (CPT1A) in melanoma leads to its degradation and enhanced T cell-dependent killing in vitro. Increasing CPT1A levels synergizes with anti-CTLA-4 treatment to suppress tumor growth in a mouse melanoma model.

    • Long Liang
    • Xinwei Kuang
    • Xiang Chen
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 680-693
  • Small cell cervical carcinoma (SCCC) is a rare but aggressive malignancy. Here, the authors report human papillomavirus features and genomic landscape in SCCC via high-throughput sequencing methods and identify MYC, SOX, NR4A, ANKRD and CEA family genes as HPV-integrated hotspots.

    • Xiaoli Wang
    • Wenlong Jia
    • Shuang Li
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10
  • Prussian blue has been used as a photothermal agent for cancer therapy. Here the authors describe the production of Prussian blue nanoparticles from S. oneidensis MR-1 bacteria and show that a Prussian blue-based mitochondria-targeting nanoplatform potentiates response to immune checkpoint blockade.

    • Dongdong Wang
    • Jiawei Liu
    • Yanli Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16
  • Electrochemical nitrate reduction to ammonia offers an attractive solution to environmental sustainability and clean energy production. Here, the authors construct spin−polarized Fe1−Ti pairs via manipulating oxygen vacancies on monolithic titanium electrode for highly efficient nitrate to ammonia conversion.

    • Jie Dai
    • Yawen Tong
    • Lizhi Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • Active translocation of DNA through nanopores usually needs enzyme assistance. Here authors present a nanopore derived from helicase E1 of bovine papillomavirus (BPV) which acts as a conductive pore embedded in lipid membrane to allow the translocation of ssDNA and unwinding of dsDNA.

    • Ke Sun
    • Changjian Zhao
    • Jia Geng
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11
  • The general photocrosslinking of semiconducting polymers is limited by efficiency and semiconductor property degradation. Here, the authors show that fluorinated phenyl azides can be molecularly designed to improve photolysis efficiency, and induce favourable partitioning of the crosslinker amongst the alkyl side chains of the polymer, thereby achieving high crosslinking efficiency without diminishing semiconducting properties.

    • Zhao-Siu Tan
    • Zaini Jamal
    • Lay-Lay Chua
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14
  • The molecular phenotypic features of epithelial ovarian cancer (EOC) remain elusive. Here, the authors perform mass spectrometry-based proteomic profiling for 269 EOC patients and reveal molecularly distinct features and potential therapeutic targets among the histological subtypes of EOC.

    • Ting-Ting Gong
    • Shuang Guo
    • Qi-Jun Wu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15
  • The synthesis of covalent organic frameworks (COFs) by a soft-template methodology is challenging. Here, the authors attach the soft templates to the COFs backbone via ion bonds, avoiding crystallization incompatibilities and allowing subsequent removal of the template by ion exchange for enhanced U(VI)/Th(IV) adsorption performance.

    • Ningning He
    • Yingdi Zou
    • Lijian Ma
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12
  • Dynamic polymer materials with reversible covalent bonds can reorganize their macromolecular architectures, and thus produce a macroscopic response to the environment. Here, the authors show dynamic covalent polyureas formed by a polyaddition reaction between pyrazoles and diisocyanates at ambient temperature in the absence of a catalyst.

    • Wen-Xing Liu
    • Zhusheng Yang
    • Jian Xu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8
  • Benzylic oxygenation of methylarenes is a direct but challenging method for aldehyde synthesis from simple starting materials. Here, the authors show an electrochemical, site-selective method for the oxidation of methyl benzoheterocycles to aromatic acetals without using chemical oxidants or transition metal catalysts.

    • Peng Xiong
    • Huai-Bo Zhao
    • Hai-Chao Xu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8
  • Designing efficient sensors for human machine interaction remains a challenge. Here, the authors present a soft robotic fingers system based on a triboelectric nanogenerator (L-TENG) sensor to capture the continuous motion of soft gripper and a soft tactile (T-TENG) sensor for tactile sensing, that can achieve an object recognition accuracy of 98.1%.

    • Tao Jin
    • Zhongda Sun
    • Chengkuo Lee
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

    • Shimin Shuai
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • The use of TCR engineered T cells holds promise for treatment of tumours, but is limited by awareness of clinically effective TCR molecules. Here the authors identify an MHC II restricted TCR that targets viral E7 of human papillomavirus type 18 and show effectivity in a murine model of solid tumour.

    • Jianting Long
    • Xihe Chen
    • Yanyan Han
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • The proton insertion mechanism in α-molybdenum trioxide remains incompletely elucidated. Herein, the authors uncover a three-proton intercalation mechanism within α-molybdenum trioxide using a specially designed electrolyte, which endows α-molybdenum trioxide with an improved specific discharge capacity.

    • Yongjiu Lei
    • Wenli Zhao
    • Husam N. Alshareef
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11
  • In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

    • Lina Sieverling
    • Chen Hong
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • The intrinsic photovoltaic effect (IPVE) in noncentrosymmetric materials has the potential to overcome the limitations of traditional photovoltaic devices. Here, the authors report the observation of a strong and gate-tunable IPVE in 1D grain boundaries of a van der Waals semiconductor, ReS2.

    • Yongheng Zhou
    • Xin Zhou
    • Xiaolong Chen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-7
  • The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • Jaegil Kim
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 94-101
  • Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

    • Yulia Rubanova
    • Ruian Shi
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved atlas of the regenerating zebrafish heart, which serves as a valuable resource for research on heart regeneration.

    • Lei Li
    • Meina Lu
    • Ying Su
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Efficient method for directly modifying endogenous plant proteins remains unavailable. Here, the authors develop a Targeted Condensation-prone-protein Degradation (TCD) strategy using a genetically-encoded degrader and show its application in controlling rice tiller number, flowering and blast resistance.

    • Ming Luo
    • Sitao Zhu
    • Guoyong Xu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • The progression from biliary tract intraepithelial neoplasia (BilIN) to gallbladder carcinoma (GBC) remains unclear. Here the authors use genomics to analyze coexisting GBC lesions, low-grade and high-grade BilINs, revealing two distinct evolutionary paths for GBC development.

    • Jianzhen Lin
    • Xinxin Peng
    • Han Liang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11
  • The utility of wet-tissue adhesives has been impeded by the suboptimal adhesive strength. Here the authors report a composite patch integrated with BP nanosheets that improve the wet-tissue adhesion by enhancing the water absorption and mechanical properties of the patch and demonstrate the uses of the patch in hemostasis, physical-activity monitoring and tumour-recurrence prevention.

    • Yuanchi Zhang
    • Cairong Li
    • Yuxiao Lai
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12
  • Antibiotic residues in soil pose health risks to farm workers. This study quantifies soil antibiotic exposure risk (SABER) using global data on soil concentrations, farm employment and working hours. The highest SABER occurs in East Africa, South Asia and Southeast Asia, with 1,000 ha farms reducing exposure effectively while sustaining rural employment.

    • Fangkai Zhao
    • Yinshuai Li
    • Liding Chen
    Research
    Nature Food
    Volume: 6, P: 353-364
  • The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

    • Lingzhao Fang
    • Jinyan Teng
    • Curtis P. Van Tassell
    Reviews
    Nature Genetics
    Volume: 57, P: 786-796
  • A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

    • Ji Chen
    • Cassandra N. Spracklen
    • Cornelia van Duijn
    Research
    Nature Genetics
    Volume: 53, P: 840-860
  • Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

    • Marc Zapatka
    • Ivan Borozan
    • Christian von Mering
    ResearchOpen Access
    Nature Genetics
    Volume: 52, P: 320-330