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The instability and sluggish kinetics of conventional Cu single-atom catalysts inhibit their industrial deployment in CO₂-to-methane conversion. Here, the authors propose a d-orbital engineering strategy to construct localized Cu sites, achieving stable industrial-level electrocatalytic methanation.

Many sporadic cases of hypertrophic cardiomyopathy have unknown genetic basis. Here, the authors identify a mutation in the gene NAP1L1 to be associated with cases of hypertrophic cardiomyopathy, linking it to cGAS-STING-IFN signaling.

How metabolic changes regulate human endoderm differentiation remains unclear. Here, the authors show that a TGFβ-driven metabolic switch reduces lactate production and enhances the TCA cycle, which controls ATP-dependent BAF complex activity to promote definitive endoderm differentiation.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

The data scarcity remains a major obstacle for material artificial intelligence. This study constructs an expert knowledge supervised learning pipeline and pre-trains a foundation model under limited data.

Electrochemical nitrate upgrading is restricted by high overpotential with low energy efficiency. Here, the authors report a metal-support modulation strategy to simultaneously optimize nitrate adsorption and water dissociation for achieving high energy efficiency at positive potentials.

Aqueous batteries often rely on acidic or alkaline electrolytes that cause side reactions and environmental concerns. Here, the authors develop a covalent organic polymer negative electrode that enables long-life Mg²⁺/Ca²⁺ storage in neutral, environmentally benign electrolytes.

Au/TiO₂@pSiO₂ catalysts achieve simultaneous high CH₄ conversion and H₂O₂ production enabled by water confinement within silica nanopores, which alters proton-coupled electron transfer pathways of water oxidation and oxygen reduction.

The mechanism of respiratory viral infection impacting distant immune responses in the uterus remains to be explored. The authors here identify pulmonary infection induces IL1R2⁺ myeloid cells migration to decidua, disrupting gestational immunity. Dipeptidyl peptidase 4 (DPP4) inhibitor treatment curbs this cell accumulation and alleviates immune dysregulation.

Cellulose triacetate-based reverse osmosis membranes are promising for water purification; overcoming the permeability-selectivity trade-off is challenging. Here, the authors incorporate carbon dots into the membrane to optimize performance.

The complexity of the evolved metabolic networks of flavonoids complicates pathway elucidation and design. Here, the authors identify enzymes that modify isoflavan scaffolds from the genome and transcriptome data of Glycyrrhiza glabra, and reconstruct de novo glabridin biosynthesis in yeast.

Riley oxidation is a powerful chemical tool that traditionally lacks stereocontrol. Here, the authors develop an engineered P450_BM3 enzyme for selective Riley-type desymmetrization of cis-diquinane, enabling the total synthesis of pentalenolactones.

Relaxor ferroelectricity is achieved in two-dimensional CuInP₂(S_1−xSe_x)₆ crystal via controlling the monoclinic and trigonal coexist phase, enabling memristors with more analog states and lower operating voltages.

Atomic catalytic pairs enable multistep transformations, yet the roles of spatial arrangement and coordination symmetry in homonuclear pairs remain unclear. Here, the authors construct atomically dispersed homonuclear Pt₁–Pt₁ pairs with asymmetric Pt₁C₃–Pt₁O₁C₃ coordination on reduced graphene oxide, enabling efficient transfer hydrogenation of azobenzene.

Hydrocyclone flow fields enhance H₂ production via shear induced lattice restructuring. Here, the authors report a multiscale framework linking reactor hydrodynamics to nanoscale catalysis, guiding industrial photocatalytic H₂ production.

Crinkler effectors were believed to exist only in pathogens. Here, the authors uncover a Crinkler‑derived genomic parasite that ADP‑ribosylates EZH2 and TRAF6 to evade epigenetic silencing and immune detection, revealing an evolutionary role for toxin‑derived proteins.

A composite sorbent combining LiCl with MOF material Ni₂Cl₂(BTDD) enables high water uptakes while low desorption temperature, achieving solar-driven water yield over 1 L m^‒2 day^‒1, which has been confirmed in field tests even across diverse regions.

Purinergic signalling dysregulation can drive inflammatory disorders, but effective targeted therapy is still lacking. Here, authors develop a smart DNA origami nanodevice that can precisely sense and metabolize high levels of extracellular ATP, thereby fine-tuning purinergic signalling and immune homeostasis.

Functional succinate dehydrogenase (SDH) complex is vital to mitochondrial homeostasis. Here the authors show that disruption of SDH assembly in the heart causes dilated cardiomyopathy via impairing the mitochondrial integrity and metabolism and that mitochondrial interventions can be an effective approach to ameliorate the disease progression.

Using tiled phage-display libraries covering swine viral proteomes, epitopes in ASFV-convalescent sera are mapped. Among 29 antigens eliciting strong IgG responses in pigs, DP283L might be a serodiagnostic marker and vaccine candidate for ASF.

Biomimetic artificial nanochannels have potential applications in signal regulation and subcellular biosensing. Here authors present artificial nanochannels based on DNA-functionalized glass nanopipettes, which when targeted to mitochondria can be used to evaluate and manipulate the interaction network between mitochondria and other organelles.

OXCT1 interference reversed triple negative breast cancer (TNBC) PD-L1 expression. KMT5A promoted OXCT1 expression, and OXCT1 increased PGK1 protein stability through succinylation modification, thereby promoting immune escape in TNBC.

Exploring the interactions between liquids and solids is critical for improving control over fluidic systems. Here, authors develop an active way to tailor various polygonal shapes of non-wetting droplet on microtextured surfaces, resulting from the anisotropic energy barriers of the contact line.

The ability of anti-cancer therapies such as radiotherapy, chemotherapy and immunotherapy to induce ferroptosis has been linked to their efficacy. Here, the authors demonstrate that SOX13 promotes ferroptosis-resistance via transactivation of SCAF1, identifying SOX13 as a targeted therapeutic vulnerability in gastric cancer.

The stereoselective construction of acyclic molecules bearing three or more contiguous stereocenters remains a long-standing challenge in modern organic synthesis. Here, the authors describe an iridium-catalyzed dynamic kinetic resolution of 2,3-diamino-1,4-diketones to enable the efficient synthesis of acyclic vicinal diamines containing four contiguous stereocenters.

Shifts in phenology can significantly impact organism fitness, ecosystem function, and the provision of ecosystem goods and services. Through a global meta-analysis, this study shows how shifts in the timing of leaf-out and first flowering due to warming and precipitation changes depend on plant functional group and climate region.

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses in temporary cardiac pacing.

Ischemic injury and reperfusion injury collectively determine total infarct size, a major prognostic factor, following myocardial infarction (MI). Here, Lv et al. develop a hydrogel system utilizing different parts of Glycyrrhiza and apply plant-based photosynthetic mechanisms to treat both ischemic and reperfusion injury in MI.

A 3D soft electronic mesh allows high-resolution electrical recording and stimulation across the full surface of neural organoids, enabling long-term studies, drug testing and optogenetic control without compromising their viability owing to its porous design.

Antihypertensive medication does not always achieve goals, especially in older adults. Lv, Wang et al. identify clonal hematopoiesis as a biomarker of resistant hypertension, highlighting it as a potential contributor and therapeutic target for poor blood pressure control.

Myocardial ischemia is a pathological condition where cardiomyocytes lack oxygen and energy supply. Here, Cheng et al. develop a photosynthetic system consisting of Chlorella pyrenoidosa (C. pyre) and upconversion nanoparticles encapsulated in a hydrogel, which upon exposure to near-infrared light, enables oxygen production by C. pyre to alleviate the hypoxic myocardial environment.

The S44 locus is a unique quadripartite (RID, RIR, RIA and RIS) distorter–restorer system governing reproductive isolation between O. longistaminata and other rice lineages, and knockout of RID can universally overcome S44-mediated reproductive barriers in the AA genome.