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Showing 1–50 of 1318 results

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Sulfated glycans engage the Ang–Tie pathway to regulate vascular development

A chemical glycobiology approach reveals that heparan-sulfate glycosaminoglycans regulate vascular development through direct interactions with angiopoietin (Ang) ligands and the Tie1 receptor of the Ang–Tie signaling system.

Matthew E. Griffin
Alexander W. Sorum
Linda C. Hsieh-Wilson
Research05 Oct 2020
Nature Chemical Biology

Volume: 17, P: 178-186
ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

Matthew J Greenway
Peter M Andersen
Orla Hardiman
Research26 Feb 2006
Nature Genetics

Volume: 38, P: 411-413
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction

The enzyme ACE2 is involved in cardiac pathology and can counteract heart failure and other cardio-pulmonary diseases. Here the authors show that bacteria produce an ACE2-like enzyme that is effective in suppressing cardiac hypertrophy and fibrosis in mice.

Takafumi Minato
Satoru Nirasawa
Keiji Kuba
ResearchOpen Access26 Feb 2020
Nature Communications

Volume: 11, P: 1-12
Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT₂R and cytoskeletal dysregulation

Increased levels of haematopoietic stem and progenitor cells in the blood have been linked to some forms of organ failure. Here, the authors show that the hormone angiotensin II increases mobilization of haematopoietic stem and progenitor cells by inducing cytoskeletal changes in bone marrow cells.

Kyung Hee Chang
Ramesh C Nayak
Jose A Cancelas
Research09 Jan 2015
Nature Communications

Volume: 6, P: 1-11
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure

Angiotensin II contracts blood vessels and has been implicated as a causative factor in hypertension. Christophe Guilluy et al. now demonstrate that the guanine exchange factor Arghef1 is required for the hypertensive effects of angiotensin II in mice, and describe a new signaling pathway by which angiotensin II triggers Jak2-dependent activation of Arghef1 to cause smooth muscle cell contraction (pages 165–166).

Christophe Guilluy
Jérémy Brégeon
Gervaise Loirand
Research24 Jan 2010
Nature Medicine

Volume: 16, P: 183-190
Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes

Aldosterone-producing zona glomerulosa cells in the adrenal gland arrange into rosette structures known to be important for morphogenesis. Here the authors show that the cells in the rosettes produce coordinated calcium activity bursts in response to angiotensin II that correlate with aldosterone production level.

Nick A. Guagliardo
Peter M. Klein
Mark P. Beenhakker
ResearchOpen Access03 Apr 2020
Nature Communications

Volume: 11, P: 1-15
IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development

Immune cells contribute to the aortic wall destruction during abdominal aortic aneurysm (AAA) development. Here, Peshkova et al. show that cytokine signaling through interleukin-27 receptor is required for Angiotensin II-induced myelopoiesis and mature myeloid cells production, thus contributing to their aortic accumulation and aneurysm progression

Iuliia O. Peshkova
Turan Aghayev
Ekaterina K. Koltsova
ResearchOpen Access06 Nov 2019
Nature Communications

Volume: 10, P: 1-15
Annexin-A1 deficiency uncovers female-specific pathways in blood pressure control and cardiovascular remodeling in mice

Annexin-A1 shields against hypertension-induced cardiovascular damage, with heightened effects in females. Estrogen-driven upregulation of annexin-A1 unveils a novel, sex-specific protective axis, offering innovative targets for tailored cardiovascular therapies.

Jaideep Singh
Kristy L. Jackson
Cheng Xue Qin
ResearchOpen Access06 Jul 2025
Communications Biology

Volume: 8, P: 1-16
The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis

Non-ischemic cardiomyopathy is a severe disease, characterized by interstitial fibrosis in the left ventricle of the heart. Here authors show that the E3 ubiquitin ligase WWP2 plays a pathogenic role in heart fibrosis via regulating a distinct monocyte population that initiates the process.

Huimei Chen
Gabriel Chew
Enrico Petretto
ResearchOpen Access30 Nov 2022
Nature Communications

Volume: 13, P: 1-21
Targeting immune–fibroblast cell communication in heart failure

A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling to cardiac fibroblasts, highlighting a role for immunomodulators in targeting cardiac fibrosis.

Junedh M. Amrute
Xin Luo
Kory J. Lavine
Research23 Oct 2024
Nature

Volume: 635, P: 423-433
Dissecting regulatory non-coding GWAS loci reveals fibroblast causal genes with pathophysiological relevance to heart failure

Heart failure can be caused by cardiac fibroblasts replacing myocytes. Here, the authors use functional genomic data from fibroblasts, genetic signals enriched in people with heart disease, and gene perturbation analyses to link disease-associated regulatory elements to protein-coding genes.

Richard Gill
Daniel R. Lu
Yi-Hsiang Hsu
ResearchOpen Access10 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Senescent cells limit p53 activity via multiple mechanisms to remain viable

To develop therapeutics that selectively eliminate pathological senescent cells it is important to understand their survival mechanisms. Here, the authors show that senescent cells manage to survive by keeping p53 activity in check through multiple mechanisms, including inhibitory mechanisms that involve p53 binding to ribonucleases.

Ines Sturmlechner
Chance C. Sine
Jan M. van Deursen
ResearchOpen Access28 Jun 2022
Nature Communications

Volume: 13, P: 1-14
Expression of foetal gene Pontin is essential in protecting heart against pathological remodelling and cardiomyopathy

Adverse cardiac remodelling is a key process leading to heart failure. Here, the authors show that expression of foetal gene Pontin (Ruvbl1) is protective against pathological remodelling and cardiomyopathy via modulation of the Hippo pathway.

Bayu Lestari
Ardiansah Bayu Nugroho
Delvac Oceandy
ResearchOpen Access14 Feb 2025
Nature Communications

Volume: 16, P: 1-21
Comparison of effects of angiotensin peptides in the regulation of clitoral cavernosum smooth muscle tone

J K Park
S Z Kim
K W Cho
Research30 Apr 2002
International Journal of Impotence Research

Volume: 14, P: 72-80
Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion

M. M. C. Arroja
E. Reid
C. McCabe
ResearchOpen Access28 Feb 2019
Scientific Reports

Volume: 9, P: 1-14
PASC (Post Acute Sequelae of COVID-19) is associated with decreased neutralizing antibody titers in both biological sexes and increased ANG-2 and GM-CSF in females

Ethan B. Jansen
Ali Toloue Ostadgavahi
Alyson A. Kelvin
ResearchOpen Access29 Apr 2024
Scientific Reports

Volume: 14, P: 1-14
Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT₁ receptor with protective action in cardiac hypertrophy

Larissa B. Teixeira
Lucas T. Parreiras-e-Silva
Claudio M. Costa-Neto
ResearchOpen Access19 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
Angiotensin II participates in mitochondrial thermogenic functions via the activation of glycolysis in chemically induced human brown adipocytes

Yukimasa Takeda
Toshikazu Yoshikawa
Ping Dai
ResearchOpen Access11 May 2024
Scientific Reports

Volume: 14, P: 1-15
Stimulation of the ACE2/Ang-(1–7)/Mas axis in hypertensive pregnant rats attenuates cardiovascular dysfunction in adult male offspring

Amanda S. M. Bessa
Érika F. Jesus
Carlos H. Castro
Research10 Sept 2019
Hypertension Research

Volume: 42, P: 1883-1893
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury

Endogenous ACE2 is a receptor for SARS-CoV-2 and a recombinant soluble ACE2 protein can inhibit SARS-CoV-2 infection acting as a decoy. Here the authors show that B38-CAP, an ACE2-like enzyme but not a decoy for the virus, is protective against SARS-CoV-2-induced lung injury in animal models.

Tomokazu Yamaguchi
Midori Hoshizaki
Keiji Kuba
ResearchOpen Access23 Nov 2021
Nature Communications

Volume: 12, P: 1-13
RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling

Vascular inflammation plays a key role in pathogenesis of major vascular diseases. Here the authors show that Regulator of G-Protein Signaling-1 (RGS1) controls macrophage function in the development of vascular inflammation that underlies atherosclerosis and abdominal aortic aneurysms in mice and humans.

Jyoti Patel
Eileen McNeill
Keith M. Channon
ResearchOpen Access18 Mar 2015
Nature Communications

Volume: 6, P: 1-11
Conditional activation of FGFR1 in the prostate epithelium induces angiogenesis with concomitant differential regulation of Ang-1 and Ang-2

S F Winter
V D Acevedo
N M Greenberg
Research12 Feb 2007
Oncogene

Volume: 26, P: 4897-4907
Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney

Oliver Domenig
Arndt Manzel
Marko Poglitsch
ResearchOpen Access21 Sept 2016
Scientific Reports

Volume: 6, P: 1-11
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension

Hypertension can lead to cognitive impairment. However, the underlying mechanisms are unclear. Here, the authors show that meningeal T cell-produced interleukin-17 activates border-associated macrophages, affecting neurovascular and cognitive functions in a mouse model of hypertension.

Monica M. Santisteban
Samantha Schaeffer
Costantino Iadecola
Research04 Dec 2023
Nature Neuroscience

Volume: 27, P: 63-77
Analysis of the aqueous humor before and after the administration of faricimab in patients with nAMD

Ryo Nonogaki
Hikaru Ota
Koji M. Nishiguchi
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-8
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall

The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensitive to angiotensin-mediated hypertension.

Xiaoping Liu
Mohamed A. El-Mahdy
Jay L. Zweier
ResearchOpen Access10 Apr 2017
Nature Communications

Volume: 8, P: 1-14
Multivariate protein landscape of host response in hospitalised patients with suspected infection in the emergency department

Authors measure plasma proteins in a cohort of hospitalised patients presenting to the emergency department with suspected infection, revealing six discrete host response clusters that were driven by pathogen exposure and organ dysfunction, and had distinct clinical characteristics, hospital courses, and responses to treatment.

Pratik Sinha
Alexandra B. Spicer
Matthew M. Churpek
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Acute infusion of angiotensin II regulates organic cation transporters function in the kidney: its impact on the renal dopaminergic system and sodium excretion

Nicolás M. Kouyoumdzian
Natalia L. Rukavina Mikusic
Marcelo R. Choi
Research16 Sept 2020
Hypertension Research

Volume: 44, P: 286-298
Naringin attenuates angiotensin II induced cardiac hypertrophy by inhibiting carbonic anhydrase II

Mahendra Mahadevaswamy
G. P. Suchitha
Jalahalli M. Siddesha
ResearchOpen Access06 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

Roberto Pola
Leona E. Ling
Jeffrey M. Isner
Research01 Jun 2001
Nature Medicine

Volume: 7, P: 706-711
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome

Loss of the metalloproteinase Adamts1 leads to aortic pathology in mice due to increased NOS2-dependent NO production. Decreased Adamts1 expression, associated with increased NOS2 expression, occurs in Marfan syndrome (MFS) mice and in MFS patients, and NOS2 inhibition prevents and reverses aortic pathology in MFS mice.

Jorge Oller
Nerea Méndez-Barbero
Juan Miguel Redondo
Research09 Jan 2017
Nature Medicine

Volume: 23, P: 200-212
Sequential, timely and controlled expression of hVEGF₁₆₅ and Ang-1 effectively improves functional angiogenesis and cardiac function in vivo

H Zhang
Y L Yuan
Z M Zhang
Research21 Mar 2013
Gene Therapy

Volume: 20, P: 893-900
Angiotensin II increases glomerular permeability by β-arrestin mediated nephrin endocytosis

Eva Königshausen
Ulf M. Zierhut
Lorenz Sellin
ResearchOpen Access22 Dec 2016
Scientific Reports

Volume: 6, P: 1-14
Loss of angiogenin function is related to earlier ALS onset and a paradoxical increase in ALS duration

Krishna C. Aluri
Joseph P. Salisbury
Jeffrey N. Agar
ResearchOpen Access28 Feb 2020
Scientific Reports

Volume: 10, P: 1-13
Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment

Dan Qi
Ming Wei
Aijuan Qu
ResearchOpen Access18 Jul 2019
Cell Death & Disease

Volume: 10, P: 1-15
Growth and Neutralization of the Trachoma Agent In Mouse Lungs

DORIS M. GRAHAM
Research01 Sept 1965
Nature

Volume: 207, P: 1379-1380
Faricimab maintains substance integrity and sterility after compounding and storage in two different polypropylene syringe types

Alexander Taschauer
Arthur Sedivy
Sebastian M. Waldstein
Research04 Dec 2024
Eye

Volume: 39, P: 943-950
Infused juice concentrate of Japanese plum Prunus mume attenuates inflammatory vascular remodeling in a mouse model of hypertension induced by angiotensin II

Keisuke Okuno
Keiichi Torimoto
Satoru Eguchi
Research13 Jun 2023
Hypertension Research

Volume: 46, P: 1923-1933
Angiotensin II and aldosterone-induced neuronal damage in neurons through an astrocyte-dependent mechanism

Li-Juan Min
Masaki Mogi
Masatsugu Horiuchi
Research07 Apr 2011
Hypertension Research

Volume: 34, P: 773-778
Angiogenin promotes tumoral growth and angiogenesis by regulating matrix metallopeptidase-2 expression via the ERK1/2 pathway

M Miyake
S Goodison
C J Rosser
Research24 Feb 2014
Oncogene

Volume: 34, P: 890-901
Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells

Aikaterini Anagnostopoulou
Livia L. Camargo
Rhian M. Touyz
ResearchOpen Access20 Oct 2020
Scientific Reports

Volume: 10, P: 1-20
Anti-hypertensive effect of hydrogen peroxide acting centrally

Mariana R. Lauar
Graziela T. Blanch
José V. Menani
Research27 May 2020
Hypertension Research

Volume: 43, P: 1192-1203
Angiotensin II directly induces muscle protein catabolism through the ubiquitin–proteasome proteolytic pathway and may play a role in cancer cachexia

P M Sanders
S T Russell
M J Tisdale
ResearchOpen Access26 Jul 2005
British Journal of Cancer

Volume: 93, P: 425-434
Association of circulating uric acid and angiotensin-(1–7) in relation to higher blood pressure in adolescents and the influence of preterm birth

Andrew M. South
Hossam A. Shaltout
Lisa K. Washburn
Research28 Apr 2020
Journal of Human Hypertension

Volume: 34, P: 818-825
Angiotensin (1-7) ameliorates the structural and biochemical alterations of ovariectomy-induced osteoporosis in rats via activation of ACE-2/Mas receptor axis

Hatem M. Abuohashish
Mohammed M. Ahmed
Salim S. Al-Rejaie
ResearchOpen Access23 May 2017
Scientific Reports

Volume: 7, P: 1-11
Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels

K J Hatfield
R Hovland
Ø Bruserud
Research18 Oct 2007
Leukemia

Volume: 22, P: 287-293
Circulating Renin Angiotensin System in Childhood Chronic Renal Failure: Marked Increase of Angiotensin-(1–7) in End-Stage Renal Disease

Ana C Simões E Silva
José Silvério S Diniz
Robson Augusto S Santos
Research01 Dec 2006
Pediatric Research

Volume: 60, P: 734-739
Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

Recurrent somatic mutations altering residues in the transmembrane domain of CADM1 are identified in aldosterone-producing adenomas. Follow-up studies implicate a role of gap junction communication in regulating aldosterone production.

Xilin Wu
Elena A. B. Azizan
Morris J. Brown
ResearchOpen Access08 Jun 2023
Nature Genetics

Volume: 55, P: 1009-1021
Reactive oxygen species in hypertension

In this Review, Touyz and colleagues discuss the role of reactive oxygen species in the pathophysiology of hypertension, focusing on the mechanisms of reactive oxygen species generation and oxidative stress in hypertension, as well as the alterations in redox signalling. They also discuss potential therapeutic strategies for targeting oxidative stress in hypertension.

Livia L. Camargo
Francisco J. Rios
Rhian M. Touyz
Reviews24 Jul 2024
Nature Reviews Cardiology

Volume: 22, P: 20-37
Angiopoietin-1 inhibits tumour growth and ascites formation in a murine model of peritoneal carcinomatosis

O Stoeltzing
S A Ahmad
L M Ellis
ResearchOpen Access29 Oct 2002
British Journal of Cancer

Volume: 87, P: 1182-1187

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