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Short-circuiting during fast charging through lithium dendrite intrusion into electrolytes is a major challenge in solid-state batteries. Here, using thermally annealed 3-nm-thick Ag coatings, lithium penetration into brittle electrolyte Li_6.6La₃Zr_1.6Ta_0.4O₁₂ is inhibited at local current densities of 250 mA cm⁻² due to an increase in surface fracture toughness.

This study shows that the Snowflake mutant in clownfish results from altered communication between pigment cells, producing enlarged white bars with jagged edges. It points to cell–cell communication as a driver of color pattern diversity in fishes.

In Li-mediated electrochemical N₂ reduction to ammonia, selectivity and activity are governed by the solid electrolyte interphase (SEI). This study reveals how the applied potential shapes the SEI properties and composition, thereby influencing reaction performance.

Anthropogenic nitrogen enrichment reduces symbiotic nitrogen fixation, but environmental factors alone cannot explain this response. This meta-analysis shows that integrating both environmental factors and plant performance traits improves the predictive accuracy of symbiotic nitrogen fixation responses by 42.7%.

Mechanical response of semiconducting polymers affects their electrical properties, yet the detail remains elusive. Zhong et al. examine the multiscale structural evolution of conjugated polymer thin films during uniaxial deformation and link it to mechanical resilience and solar cell performance.

Researchers report a solid that is amorphous in two dimensions but crystalline in the third, made of stacked disordered atomic layers. This shows that crystalline and amorphous order can coexist within a single material depending on direction.

Molecular glue degraders have consistently been discovered retrospectively, despite their increasing importance. Herein, a high-throughput approach is described that modifies existing ligands into molecular glue degraders.

Here researchers reveal a microexon in the Ank3 gene encoding Ankyrin G allows cortical interneurons to fine-tune calcium signaling and firing, revealing the contribution of alternative splicing to the functional diversity among different types of neurons.

DNA recognition and cleavage control in type II topoisomerases are poorly understood processes. Here, the authors determine cleaved and uncleaved structures of supercoiled DNA-bound topoisomerase VI that reveal how the enzyme activates its cleavage state and prefers to act at deformable substrates.

Supersolid phases are quantum-entangled states of matter exhibiting the dual characteristics of superfluidity and solidity. Here, the authors map the phase diagram of K₂Co(SeO₃)₂. and identify signatures of two supersolid phases separated by a 1/3 magnetization plateau.

Surface plasmon-mediated steady-state and on-demand electronic spin modulation effectively activates light-driven plasmonic catalysis, facilitating polarization reactant activation and preferential reaction pathway modulation.

Continuous monoculture of banana can result in proliferation of parasitic nematodes. Here the authors show that in the long term, soil can become suppressive to disease and this is associated with enrichment of free-living nematodes and Bacillus bacteria.

Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

This Review provides insights into the nanoscale physicochemical and electrochemical processes in non-aqueous electrolyte solutions for lithium metal batteries and explores emerging research directions for accelerated and iterative approaches.

Gestational exposure of mice to the obesogen tributyltin alters 3-D chromatin interactions in primordial germ cells leading to stable reduction of hepatic Ide expression and predisposing male descendants to insulin dysregulation and obesity.

Using recent TMTH-sulfoximine (THS)-based biorthogonal chemistry in live cells, Smits et al. identify micro- and nanodomains in cell-cell and cell-matrix contacts of heterogenous glycocalyx density in invading melanoma cells.

Li-metal batteries suffer from sluggish kinetics at low temperatures. Here, authors propose a guideline for rational electrolyte solvent screening and design a class of asymmetric ethers, which bestows the Li metal pouch cell with a high specific energy of 345.3 Wh kg⁻¹ over 40 cycles at −40 °C.

ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.

Here they show that FOXF2 is required for pericyte maturation and function during postnatal alveolar morphogenesis. FOXF2 is required in pericytes to induce angiogenesis after neonatal hyperoxic injury, revealing a link between pericyte-endothelial crosstalk and bronchopulmonary dysplasia pathogenesis.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Amorphous sulfurized polyacrylonitrile suppresses polysulfide shuttling in Li–S batteries, enabling long cycle life, but the structural processes involved during synthesis and initial cycling remained unclear. An operando pair distribution function, wide-angle scattering and sulfur absorption spectroscopy reveal S–C bond formation, π–π stacking and sulfur-chain shortening, which enable reversible sulfur redox.

Continuously trapped atoms provide advantage for atom interferometry, yet current schemes are limited by dephasing. Here, the authors develop a Floquet-engineered atom interferometry platform for quantum force sensing purposes, unveiling regimes where the interferometric phase is insensitive to noise.

Rafting dispersal can facilitate responses to environmental change. Here, authors integrate dispersal simulations, ecological genomics, and salinity stress experiments to elucidate the rafting dynamics and adaptive shifts of crustaceans.

Neuroinflammation triggers DNA damage and subsequent parthanatos-mediated neuron death. Inhibiting parthanatos in a mouse model of autoimmune inflammation is neuroprotective and reduces disease-associated paralysis.

This manuscript from Choquette and colleagues finds that sclerostin gene expression is up-regulated in bone by β3-adrenergic signaling via an adipose to bone relay and acts as an endocrine factor to inhibit adipose tissue beiging in mice.

A high-temperature immiscible blend of two dipolar polymers that self-assemble into three-dimensional all-polymer nanocomposites allows markedly enhanced dielectric and energy storage performances over a broad temperature range.

The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD⁺ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and modulated lipid metabolism in vitro and in a mouse hepatic steatosis model.

Therapies combining chemotherapy and immune checkpoint inhibitors have shown limited efficacy in patients with advanced pancreatic ductal adenocarcinoma (PDAC). Here the authors report the results of a pilot phase 1 trial of neoadjuvant modified Folfirinox plus nivolumab in borderline-resectable PDAC, including safety, efficacy and immunological correlates.

Lithium-ion battery cathode lifetime is limited by large expansion and contraction during cycling. This study uses electrochemical activation to suppress collapse in LiNi_0.9Mn_0.1O₂ cathodes, achieving improved capacity and cycle life.

Polarons play a crucial role in determining the (photo)electrocatalytic activity of semiconductors. Here, the authors report a reversible, potential-driven method to generate Ti³⁺ polarons on TiO₂, creating dynamic active sites that break the adsorption-potential linearity and boost hydrogen evolution.

Photocatalytic water splitting using a single particulate photocatalyst is a cost-efficient approach for sustainable hydrogen production. Here, the authors report a nanoscale Ba_xSr_1-xTaO₂N solid-solution photocatalyst exhibits an apparent quantum efficiency of 13.5% for H₂ evolution at 420 nm.

GDF15 has been associated with cancer-associated cachexia. Here, the authors show that STK11/LKB1 loss-of-function mutations in non-small cell lung cancer result in an exaggerated integrated stress response culminating in the tumor cell secretion of the cytokine GDF15 promoting cachexia.

Melting ice and associated sea-level change will expose new land in Antarctica. Here the authors quantify this change and combine it with our understanding of known Antarctic mineral occurrences, showing that substantial mineral deposits may become accessible over the next few centuries in Antarctica.

Native state proteomics of PV interneurons revealed unique molecular features of high translational and metabolic activity, and enrichment of Alzheimer’s risk genes. Early amyloid pathology exerted unique effects on mitochondria, mTOR signaling and neurotransmission in PV neurons.

Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.

This study applies machine learning to fMRI data to map developmental variations in functional connectivity, uncovering heterogeneity across individuals and cortical regions that predicts neurocognitive maturation in youth.

The use of antimicrobial agents can exacerbate the proliferation of antimicrobial resistance genes, which can put public health at risk; evaluating this risk requires proper monitoring. An extensive investigation of Australian wastewater reveals a distinct correlation between the type of antimicrobial used and the socioeconomic status of the population.

The herpes simplex virus lytic-latent balance is incompletely understood. In this study, the authors show that it is controlled by the relative abundance of host activating and repressive forkhead box (FOX) transcription factors that recruit epigenetic cofactors to the viral genome to remodel viral chromatin.

Population-level analyses and in vitro experiments show that a specific genetic variant of cyclin D3 inhibits the growth of the malaria-causing parasite Plasmodium falciparum in erythrocytes, and suggest that its high frequency in Sardinia was driven by past endemic malaria.

Ferromagnetic systems produced by the transition metal doping of semiconductors may be used as components of spintronic devices. Here, a new ferromagnet, Li_1+y(Zn_1-xMn_x)As, is prepared in bulk quantities and shown to have a critical temperature approaching 50 K.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

A technique called condense-seq has been developed to measure nucleosome condensability and used to show that mononucleosomes contain sufficient information to condense into large-scale compartments without requiring any external factors.

Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.

Several transmission-blocking vaccine candidates based on Pfs230 and Pfs48/45 are in clinical development, but it remains unclear whether they will demonstrate high efficacy. Here, the authors develop a stabilized chimeric antigen presenting potent epitopes from Pfs230 and Pfs48/45 in a single construct and demonstrate induction of transmission-reducing antibodies when female mice are immunized with the antigen in a self-assembling protein nanoparticle formulation.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Mapping global alluvial channel patterns reveals a hidden dominance of anabranching channels, constituting nearly half of the total reach length globally.

Although rechargeable lithium–air batteries are receiving significant attention because of their high theoretical specific energy, carbon cathodes that are currently used decompose during oxidation and promote electrolyte decomposition on cycling. A titanium carbide-based cathode is now shown to reduce side-reactions, and exhibits enhanced reversible formation and decomposition of Li₂O₂.

Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hippocampal neuronal and non-neuronal cell types, highlighting functional differences between CA1 and CA3.

Plasma p-tau217 tests used to develop clocks that predict when cognitively unimpaired individuals would develop symptoms of Alzheimerʼs disease.