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Showing 1–50 of 63 results

Advanced filters: Author: M Tohyama Clear advanced filters

Taurine from tumour niche drives glycolysis to promote leukaemogenesis

The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.

Sonali Sharma
Benjamin J. Rodems
Jeevisha Bajaj
ResearchOpen Access14 May 2025
Nature

Volume: 644, P: 263-272
Human primitive neuroectodermal tumour cells behave as multipotent neural precursors in response to FGF2

E A Derrington
N Dufay
M-F Belin
Research01 Oct 1998
Oncogene

Volume: 17, P: 1663-1672
TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells

Hypomethylating agents (HMAs) are frontline therapy for Myelodysplasia, but their efficacy is limited. Here, the authors show that depleting the dual E3-ligase TOPORS synergizes with HMAs by enhancing DNA damage in leukemia cells, improving survival in mouse models without preventing healthy hematopoiesis.

Peter Truong
Sylvie Shen
John E. Pimanda
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-19
Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia

H. Karel Nieuwenhuis
Jan Willem N. Akkerman
Jan J. Sixma
Research05 Dec 1985
Nature

Volume: 318, P: 470-472
A cluster of three GABA_A receptor subunit genes is deleted in a neurological mutant of the mouse p locus

Yoshimichi Nakatsu
Rachel F. Tyndale
Murray H. Brilliant
Research29 Jul 1993
Nature

Volume: 364, P: 448-450
Deficiency of the β3 subunit of the type A γ–aminobutyric acid receptor causes cleft palate in mice

Cymbeline T. Culiat
Lisa J. Stubbs
Eugene M. Rinchik
Research01 Nov 1995
Nature Genetics

Volume: 11, P: 344-346
A thalamic nucleus specific for pain and temperature sensation

A. D. Craig
M. C. Bushnell
A. Blomqvist
Research29 Dec 1994
Nature

Volume: 372, P: 770-773
Generation of New Benanomicin Analogues by Biotransformation Using Escherichia coli Expressing Actinomycete Cytochrome P450

Hiroyuki Kumagai
Maya Umekita
Yuzuru Akamatsu
Research01 Jun 2008
The Journal of Antibiotics

Volume: 61, P: 394-399
Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice

How and to what extent oligodendrocytes (OLs) contribute to learning and cognition is not well understood. Here, the authors show that the performance of mice in working memory-dependent cognitive tasks depends on OL genesis and is proportional to the number of OL precursors and OLs generated during training.

Takahiro Shimizu
Stuart G. Nayar
William D. Richardson
ResearchOpen Access14 Oct 2023
Nature Communications

Volume: 14, P: 1-19
Quasiparticle interference and superconducting gap in Ca_2−xNa_xCuO₂Cl₂

T. Hanaguri
Y. Kohsaka
H. Takagi
Research28 Oct 2007
Nature Physics

Volume: 3, P: 865-871
Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice

Feeding and stress are deeply related to each other, yet neural circuits how they interact are not fully understood. Here, the authors show that the parabrachial-to-parasubthalamic nucleus pathway is involved in fear-induced feeding suppression.

Takashi Nagashima
Suguru Tohyama
Ayako M. Watabe
ResearchOpen Access30 Dec 2022
Nature Communications

Volume: 13, P: 1-17
High-energy spin and charge excitations in electron-doped copper oxide superconductors

Understanding spin dynamics in the cuprates is vital to understanding the origin high-temperature superconductivity. X-ray and neutron spectra obtained by Ishii et al.suggest that the spins in electron-doped cuprates are itinerant, in contrast to recent evidence that in hole-doped cuprates they are localized.

K. Ishii
M. Fujita
J. Mizuki
Research25 Apr 2014
Nature Communications

Volume: 5, P: 1-8
Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid

M Yaguchi
K Miyazawa
K Toyama
Research01 Jun 1997
Leukemia

Volume: 11, P: 779-787
Five-aza-2′-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells

Takayuki Tsujioka
Akira Yokoi
Kaoru Tohyama
ResearchOpen Access18 Nov 2015
Scientific Reports

Volume: 5, P: 1-12
ORP150 protects against hypoxia/ischemia-induced neuronal death

Michio Tamatani
Tomohiro Matsuyama
Masaya Tohyama
Research01 Mar 2001
Nature Medicine

Volume: 7, P: 317-323
Magnon interactions in a moderately correlated Mott insulator

Magnetic excitations in infinite-layer cuprates have been intensively studied. Here the authors use resonant inelastic x-ray scattering and theoretical calculations to study magnons in thin films of SrCuO₂, finding distinct magnon dispersion attributed to renormalization due to quantum fluctuations.

Qisi Wang
S. Mustafi
J. Chang
ResearchOpen Access24 Jun 2024
Nature Communications

Volume: 15, P: 1-7
GABA_A and Opioid Receptors of the Central Nucleus of the Amygdala Selectively Regulate Ethanol-Maintained Behaviors

Katrina L Foster
Peter F McKay
Harry L June
Research03 Dec 2003
Neuropsychopharmacology

Volume: 29, P: 269-284
Haploinsufficiency of miR-143 and miR-145 reveal targetable dependencies in resistant del(5q) myelodysplastic neoplasm

Nadia Gharaee
Joanna Wegrzyn-Woltosz
Aly Karsan
ResearchOpen Access25 Feb 2025
Leukemia

Volume: 39, P: 917-928
Metabolic studies of human primitive neuroectodermal tumour cells by proton nuclear magnetic resonance spectroscopy

C-L Florian
T Pietsch
SR Williams
Research01 Apr 1997
British Journal of Cancer

Volume: 75, P: 1007-1013
Diagonal nematicity in the pseudogap phase of HgBa₂CuO_4+δ

One of the proposed explanations for the unusual pseudogap behaviour of cuprate superconductors is the formation of an electron nematic phase. Murayama et al. find magnetic anisotropy in the pseudogap regime of HgBa₂CuO_4+δ, providing evidence for anomalous nematic ordering.

H. Murayama
Y. Sato
Y. Matsuda
ResearchOpen Access23 Jul 2019
Nature Communications

Volume: 10, P: 1-7
Phonon-induced disorder in dynamics of optically pumped metals from nonlinear electron-phonon coupling

Superconductivity reported in metals driven away from equilibrium via optical pumping has been proposed to arise from nonlinear coupling between electrons and optically excited phonons. The authors use an exact approach to show that here, disorder, which disfavors superconductivity, emerges even though the system is translationally invariant.

John Sous
Benedikt Kloss
Andrew J. Millis
ResearchOpen Access04 Oct 2021
Nature Communications

Volume: 12, P: 1-8
Metallothionein expression correlates with metastatic and proliferative potential in squamous cell carcinoma of the oesophagus

Y Hishikawa
T Koji
N Nagasue
ResearchOpen Access24 Sept 1999
British Journal of Cancer

Volume: 81, P: 712-720
Establishment and characterization of a megakaryoblast cell line with amplification of MLL

RJ Allen
SD Smith
N Zeleznik-Le
Research24 Jul 1998
Leukemia

Volume: 12, P: 1119-1127
Aversive experiences induce valence plasticity of instructive signals to change future learning rules in mice

Biological and mathematical analyses of synaptic plasticity in the brainstem-to-amygdala pathway reveal its role in modulating aversive valence, providing insights into state-dependent learning-rule change and potential therapeutic targets for PTSD.

Suguru Tohyama
Takashi Nagashima
Ayako M. Watabe
ResearchOpen Access04 Jul 2025
Communications Biology

Volume: 8, P: 1-16
DISC1 regulates N-cadherin and β1-integrin expression in neurons

T Hattori
S Shimizu
M Tohyama
Research13 Aug 2010
Molecular Psychiatry

Volume: 15, P: 778
The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia

Madeline Niederkorn
Chiharu Ishikawa
Daniel T. Starczynowski
ResearchOpen Access31 Aug 2021
Leukemia

Volume: 36, P: 438-451
Adult onset limb-girdle type mitochondrial myopathy with a mitochondrial DNA np8291 A-to-G substitution

Keiko Hirata
M. Nakagawa
Mitsuhiro Osame
Research01 May 1999
Journal of Human Genetics

Volume: 44, P: 210-214
Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis

A Matsuoka
A Tochigi
K Tohyama
Research04 Feb 2010
Leukemia

Volume: 24, P: 748-755
Zero-doping state and electron–hole asymmetry in an ambipolar cuprate

High-temperature copper oxide superconductors are usually doped with holes or electrons, not both. The discovery of a material that can be doped with both electrons and holes finally clarifies the region of low doping and the effect of the added dopants.

Kouji Segawa
M. Kofu
Yoichi Ando
Research04 Jul 2010
Nature Physics

Volume: 6, P: 579-583
Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia

H Kiyoi
T Naoe
R Ohno
Research01 Sept 1997
Leukemia

Volume: 11, P: 1447-1452
Vitamin K2 selectively induces apoptosis of blastic cells in myelodysplastic syndrome: flow cytometric detection of apoptotic cells using APO2.7 monoclonal antibody

M Yaguchi
K Miyazawa
K Toyama
Research02 Sept 1998
Leukemia

Volume: 12, P: 1392-1397
Vitamin K₂ induces apoptosis of a novel cell line established from a patient with myelodysplastic syndrome in blastic transformation

J Nishimaki
K Miyazawa
T Takiguchi
Research09 Sept 1999
Leukemia

Volume: 13, P: 1399-1405
Overexpression of tumor necrosis factor (TNF)-α and interferon (IFN)-γ by bone marrow cells from patients with myelodysplastic syndromes

M Kitagawa
I Saito
K Hirokawa
Research01 Dec 1997
Leukemia

Volume: 11, P: 2049-2054
Presenilin and the UPR

K. Imaizumi
T. Katayama
M. Tohyama
Correspondence01 May 2001
Nature Cell Biology

Volume: 3, P: E104
A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers

N Sugino
M Kawahara
A Takaori-Kondo
Research17 Feb 2017
Leukemia

Volume: 31, P: 2303-2314
X-Ray Photoelectron Spectroscopic Studies of Polyquinazolones: An Assessment of the Degree of Cyclization

Hardy S O Chan
T S Andy Hor
B T G Tan
Research01 Oct 1990
Polymer Journal

Volume: 22, P: 883-892
Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support

Tae Higuchi
Tomomi Ide
Kohtaro Abe
ResearchOpen Access28 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population

Shota Ikeda
Keisuke Shinohara
Shintaro Kinugawa
ResearchOpen Access03 Jan 2024
Scientific Reports

Volume: 14, P: 1-8
An MDS-derived cell line and a series of its sublines serve as an in vitro model for the leukemic evolution of MDS

Jun-ichiro Kida
Takayuki Tsujioka
Kaoru Tohyama
Research28 Jun 2018
Leukemia

Volume: 32, P: 1846-1850
The level of MnSOD is directly correlated with grade of brain tumours of neuroepithelial origin

M Landriscina
F Remiddi
T Galeotti
Research01 Dec 1996
British Journal of Cancer

Volume: 74, P: 1877-1885
Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors

John P Russell
Shogo Shinohara
Jay L Rothstein
Research17 Jul 2003
Oncogene

Volume: 22, P: 4569-4577
BCL-2 family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies

J M Bogenberger
S M Kornblau
R Tibes
ResearchOpen Access23 Jan 2014
Leukemia

Volume: 28, P: 1657-1665
Vitamin K2 therapy for a patient with myelodysplastic syndrome

M Yaguchi
K Miyazawa
K Toyama
Correspondence27 Jan 1999
Leukemia

Volume: 13, P: 144-145
Adenovirus facilitated infection of human cells with ecotropic retrovirus

TH Scott-Taylor
HF Gallardo
M Sadelain
Research21 May 1998
Gene Therapy

Volume: 5, P: 621-629
Efficacy of intensive lipid-lowering therapy with statins stratified by blood pressure levels in patients with type 2 diabetes mellitus and retinopathy: Insight from the EMPATHY study

Among type 2 diabetic patients with retinopathy having blood pressure ≥130/80 mmHg, intensive statin therapy targeting LDL-C <70 mg/dL had benefits in primary CVD prevention compared with standard therapy.

Keisuke Shinohara
Shota Ikeda
Hiroyuki Tsutsui
Research15 Sept 2021
Hypertension Research

Volume: 44, P: 1606-1616
TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells

M C Anania
M Sensi
A Greco
Research21 Feb 2011
Oncogene

Volume: 30, P: 3011-3023
A higher resting heart rate is associated with cardiovascular event risk in patients with type 2 diabetes mellitus without known cardiovascular disease

High resting heart rate (RHR), particularly ≥70 bpm, was associated with the risk of cardiovascular events compared to RHR 60-69 bpm in patients with type 2 diabetes mellitus (T2DM), diabetic retinopathy, and hyperlipidemia, but without known cardiovascular disease.

Shota Ikeda
Keisuke Shinohara
Hiroyuki Tsutsui
Research27 Jan 2023
Hypertension Research

Volume: 46, P: 1090-1099
Impaired Object Recognition Memory Following Methamphetamine, but not p-Chloroamphetamine- or d-Amphetamine-Induced Neurotoxicity

Annabelle M Belcher
Steven J O'Dell
John F Marshall
Research18 May 2005
Neuropsychopharmacology

Volume: 30, P: 2026-2034
Fluorescence laser microdissection reveals a distinct pattern of gene activation in the mouse hippocampal region

Wataru Yoshioka
Nozomi Endo
Chiharu Tohyama
ResearchOpen Access07 Nov 2012
Scientific Reports

Volume: 2, P: 1-7
The Reinforcing Properties of Alcohol are Mediated by GABA_A1 Receptors in the Ventral Pallidum

Harry L June
Katrina L Foster
Phil Skolnick
Research20 May 2003
Neuropsychopharmacology

Volume: 28, P: 2124-2137

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