Nature Search

Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture

The recently discovered aptamer Beetroot is a homodimeric RNA that binds and activates DFAME, a conditional, red-shifted fluorophore derived from GFP. Here the authors determine the Beetroot-DFAME co-crystal structure, which is distinctively different from that of similar RNA aptamer Corn.

Luiz F. M. Passalacqua
Mary R. Starich
Adrian R. Ferré-D’Amaré
ResearchOpen Access23 May 2023
Nature Communications

Volume: 14, P: 1-12
Detoxication During Secondary Growth in Plants

C. M. STEWART
Research30 Apr 1960
Nature

Volume: 186, P: 374-375
Effects of temporal, geographical and environmental factors on salmon lice (Lepeophtheirus salmonis) levels of Atlantic salmon (Salmo salar) in Ireland

Bela Klimesova
Olga Lyashevska
Katie O’Dwyer
ResearchOpen Access03 Oct 2025
Scientific Reports

Volume: 15, P: 1-13
Polytene Chromosome Structure in Relation to the “Folded Fibre” Concept

E. J. DuPRAW
PETER M. M. RAE
Research01 Nov 1966
Nature

Volume: 212, P: 598-600
Impacts of soret and dufour possessions on micropolar fluid past a stretching sheet in a porous medium

Shakila Ahamedsheriff
Vijayaragavan Rajaram
Imed Kedim
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-18
Nature and nurture – lessons from chemical carcinogenesis

Andreas Luch
Reviews20 Jan 2005
Nature Reviews Cancer

Volume: 5, P: 113-125
Structures of HIV-1 RT–DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

Steve Tuske
Stefan G Sarafianos
Eddy Arnold
Research25 Apr 2004
Nature Structural & Molecular Biology

Volume: 11, P: 469-474
Nanopore detection of single-nucleotide RNA mutations and modifications with programmable nanolatches

The hybridization thermodynamics of programmable DNA nanostructures forming metastable loop structures on RNA generate distinct electrical signals during translocation through solid-state nanopores, enabling the identification of single-base alterations.

Yunxuan Li
Siong Chen Meng
Ulrich F. Keyser
ResearchOpen Access27 Jun 2025
Nature Nanotechnology

P: 1-9
Congenital Porphyria in Bovines : First Living Cases in Britain

E. C. AMOROSO
R. M. LOOSMORE
B. E. TOOTH
Research03 Aug 1957
Nature

Volume: 180, P: 230-231
Temperature and CO₂ concentration in honey bee hives exhibit circadian rhythms

W. G. Meikle
M. Weiss
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
DNA-directed DNA Polymerase Activity in Oncogenic RNA Viruses

S. SPIEGELMAN
A. BURNY
K. WATSON
Research05 Sept 1970
Nature

Volume: 227, P: 1029-1031
A potentially abundant junctional RNA motif stabilized by m⁶A and Mg²⁺

N⁶-Methyladenosine (m⁶A) is a post-transcriptional RNA modification that modulates RNA structure through a destabilization of m⁶A base pairing. Here the authors use NMR and UV melting experiments and show that m⁶A can also stabilize m⁶A–U base pairs and global RNA structure when positioned adjacent to a 5ʹ bulge.

Bei Liu
Dawn K. Merriman
Hashim M. Al-Hashimi
ResearchOpen Access17 Jul 2018
Nature Communications

Volume: 9, P: 1-10
Closed-loop control of theta oscillations enhances human hippocampal network connectivity

Closed-loop brain stimulation of the human hippocampal theta rhythm produces lasting enhancement of network communication. This implicates theta rhythms in human hippocampal network communication and provides a possible route to memory modulation.

James E. Kragel
Sarah M. Lurie
Joel L. Voss
ResearchOpen Access30 Apr 2025
Nature Communications

Volume: 16, P: 1-11
On Jim Watson's APOE status: genetic information is hard to hide

Dale R Nyholt
Chang-En Yu
Peter M Visscher
Correspondence22 Oct 2008
European Journal of Human Genetics

Volume: 17, P: 147-149
Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction

Determining dynamic ensembles of biomolecules is still challenging. Here the authors present an approach for rapid RNA ensemble determination that combines RNA structure prediction tools and NMR residual dipolar coupling data and use it to determine atomistic ensemble models for a variety of RNAs.

Honglue Shi
Atul Rangadurai
Hashim M. Al-Hashimi
ResearchOpen Access02 Nov 2020
Nature Communications

Volume: 11, P: 1-14
Reply to Stokes and Watson

V P Govande
J Lagatta
M A Basir
Correspondence27 Sept 2013
Journal of Perinatology

Volume: 33, P: 823-824
Testing the iron hypothesis in ecosystems of the equatorial Pacific Ocean

J. H. Martin
K. H. Coale
N. W. Tindale
Research08 Sept 1994
Nature

Volume: 371, P: 123-129
Diverse organic-mineral associations in Jezero crater, Mars

Raman and fluorescence spectra, consistent with several species of aromatic organic molecules, are reported in the Crater Floor sequences of Jezero crater, Mars, suggesting multiple mechanisms of organic synthesis, transport, or preservation.

Sunanda Sharma
Ryan D. Roppel
Anastasia Yanchilina
ResearchOpen Access12 Jul 2023
Nature

Volume: 619, P: 724-732
Evidence for the Existence of Cosmic Ray Particles with Energy ⩾ 5×10¹⁹ eV

D. ANDREWS
A. C. EVANS
J. G. WILSON
Research15 Jul 1968
Nature

Volume: 219, P: 343-346
Structure of Papain

J. DRENTH
J. N. JANSONIUS
B. G. WOLTHERS
Research08 Jun 1968
Nature

Volume: 218, P: 929-932
A Transatlantic Communication Experiment Via Echo I Satellite

H. CARRU
R. GENDRIN
M. REYSSAT
Research28 Jan 1961
Nature

Volume: 189, P: 268-271
H3K56 acetylation regulates chromatin maturation following DNA replication

Here, the authors show that histone H3 through H3K56 acetylation, is essential for chromatin remodelling in nascent chromatin post-DNA replication. Subsequent H3K56 deacetylation during G2/M signals chromatin maturation, ensures both genome and epigenome integrity.

Shoufu Duan
Ilana M. Nodelman
Zhiguo Zhang
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Determinants of mosaic chromosomal alteration fitness

Here, the authors use passenger mutations to quantify expansion rate in ~6,000 people with mosaic chromosomal alterations in the NHLBI TOPMed cohort, finding associations between growth rate and blood counts along with germline genetic modulators of growth rate.

Yash Pershad
Taralynn Mack
Alexander G. Bick
ResearchOpen Access07 May 2024
Nature Communications

Volume: 15, P: 1-10
Substantial export of suspended sediment to the global oceans from glacial erosion in Greenland

Approximately 8% of the fluvial suspended sediment exported to the world’s oceans comes from rivers draining the Greenland ice sheet, according to an analysis of satellite imagery. Furthermore, the export is dominated by areas where subglacial erosion is high.

I. Overeem
B. D. Hudson
M. Morlighem
Research16 Oct 2017
Nature Geoscience

Volume: 10, P: 859-863
Three-dimensional Fourier Synthesis of Tosyl-elastase at 3.5 Å Resolution

H. C. WATSON
D. M. SHOTTON
HILARY MUIRHEAD
Research28 Feb 1970
Nature

Volume: 225, P: 806-811
A fused weighted federated learning-based adaptive approach for early-stage drug prediction

Mohammed Salahat
Hani Q. R. Al-Zoubi
Taher M. Ghazal
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-10
Dynamic basis for dG•dT misincorporation via tautomerization and ionization

A kinetic model is proposed to predict the probability of dG•dT misincorporation across different polymerases, and provides mechanisms for sequence-dependent misincorporation.

Isaac J. Kimsey
Eric S. Szymanski
Hashim M. Al-Hashimi
Research31 Jan 2018
Nature

Volume: 554, P: 195-201
Large reductions in tropical bird abundance attributable to heat extreme intensification

Climate change poses a growing threat to biodiversity, but disentangling its overall impact from other anthropogenic stressors is challenging. Here the authors use a data-driven climate attribution framework to identify a key role of heat extremes in causing changes in bird populations globally.

Maximilian Kotz
Tatsuya Amano
James E. M. Watson
Research11 Aug 2025
Nature Ecology & Evolution

Volume: 9, P: 1897-1909
Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy

Uncertainty associated with solution-based electron-transfer studies of DNA–metal-complex systems has now been overcome by combining X-ray and time-resolved infrared data obtained for ruthenium polypyridyl–DNA crystals. Using these methods both the geometry of the reaction site and the kinetics of the reversible photo-induced one-electron oxidation of guanine have been determined.

James P. Hall
Fergus E. Poynton
Susan J. Quinn
Research19 Oct 2015
Nature Chemistry

Volume: 7, P: 961-967
Whole-genome sequencing of 490,640 UK Biobank participants

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

Keren Carss
Bjarni V. Halldorsson
Ole Schulz-Trieglaff
ResearchOpen Access06 Aug 2025
Nature

Volume: 645, P: 692-701
Phosphorylation of Xylose by Extracts of Pseudomonas Hydrophila

ROLF M. HOCHSTER
R. WADE WATSON
Research30 Aug 1952
Nature

Volume: 170, P: 357-358
Abnormal Haem Binding and Globin SH Group Blockade in Unstable Haemoglobins

H. S. JACOB
M. C. BRAIN
H. LEHMANN
Research29 Jun 1968
Nature

Volume: 218, P: 1214-1217
Haemoglobin J Cape Town—α₂ 92 Arginine→Glutamine β₂

M. C. BOTHA
D. BEALE
H. LEHMANN
Research19 Nov 1966
Nature

Volume: 212, P: 792-795
Evidence for Solar Particle Production above ∼75 GeV

STEPHEN M. SCHINDLER
PHILIP D. KEARNEY
Research30 Jun 1972
Nature

Volume: 237, P: 503-505
Conditions for the Static Equilibrium and Circulation of Insulating Liquids in Electric Fields

M. J. GROSS
Research22 Nov 1969
Nature

Volume: 224, P: 763-766
Leaf venation network evolution across clades and scales

This study reconstructs the evolution of leaf venation networks, describing the transition from fewer, corrugated veins to high vein density and smoother loops. It also suggests herbivory as a potential driver of venation architectural changes.

Ilaine Silveira Matos
Bradley Vu
Benjamin W. Blonder
Research06 Jun 2025
Nature Plants

Volume: 11, P: 1127-1141
Direct observation of structure in the cosmic microwave background

S. Hancock
R. D. Davies
J. E. Beckman
Research27 Jan 1994
Nature

Volume: 367, P: 333-338
Sm—Nd systematics of Lewisian gneisses: implications for the origin of granulites

P. J. Hamilton
N. M. Evensen
J. Tarney
Research04 Jan 1979
Nature

Volume: 277, P: 25-28
Production of Superheavy Nuclei by Multiple Capture of Neutrons

W. M. HOWARD
J. R. NIX
Research04 Jan 1974
Nature

Volume: 247, P: 17-20
Spontaneous formation and base pairing of plausible prebiotic nucleotides in water

One of the questions for prebiotic chemistry is the formation of complementary base pairing systems. Here, the authors show that plausible two prebiotic heterocycles can form glycosidic bonds with ribose in water and that these spontaneously base-pair in aqueous solution.

Brian J. Cafferty
David M. Fialho
Nicholas V. Hud
ResearchOpen Access25 Apr 2016
Nature Communications

Volume: 7, P: 1-8
Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions

Upon encounter of abasic lesions, a highly-prevalent DNA damage, RNA polymerase I experiences a two-step pausing-stalling mechanism that is described here through cryo-EM analysis. The structures uncover the nucleotide entry mechanism and provide insights into intrinsic RNA cleavage.

Alicia Santos-Aledo
Adrián Plaza-Pegueroles
Carlos Fernández-Tornero
ResearchOpen Access06 Jun 2025
Nature Communications

Volume: 16, P: 1-13
In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery

Gene editing approaches are widely used for correcting mutations, but their application is largely limited to cells and not living animals. Here the authors show that in vivoγPNA-mediated editing of a β-globin mutation is promoted by SCF and leads to sustained normalization of blood haemoglobin levels β-thalassemic mice.

Raman Bahal
Nicole Ali McNeer
Peter M. Glazer
ResearchOpen Access26 Oct 2016
Nature Communications

Volume: 7, P: 1-14
Infra-Red Spectral Analysis of the Apoproteins of Some Haemoglobins and Myoglobins

M. Z. ATASSI
LEO R. CACCIOTTI
Research19 Mar 1966
Nature

Volume: 209, P: 1211-1213
Generative and predictive neural networks for the design of functional RNA molecules

Designing high performance RNA molecules is a unifying challenge across many areas of biotechnology research. Here, authors develop GARDN and SANDSTORM, a data-efficient generative AI framework for designing a diverse set of RNA molecules. These tools represent a promising addition to the sequence design toolkit that could be used in many domains.

Aidan T. Riley
James M. Robson
Alexander A. Green
ResearchOpen Access04 May 2025
Nature Communications

Volume: 16, P: 1-17
Three abundance classes in HeLa cell messenger RNA

J. O. Bishop
J. G. Morton
Melville Richardson
Research19 Jul 1974
Nature

Volume: 250, P: 199-204
Molecular Weight Distribution Changes in Polymers on Irradiation

M. A. CROOK
F. S. WALKER
Research22 Jun 1963
Nature

Volume: 198, P: 1163-1165
Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping

A method termed ac⁴C-seq is introduced for the transcriptome-wide mapping of the RNA modification N⁴-acetylcytidine, revealing widespread temperature-dependent acetylation that facilitates thermoadaptation in hyperthermophilic archaea.

Aldema Sas-Chen
Justin M. Thomas
Schraga Schwartz
Research17 Jun 2020
Nature

Volume: 583, P: 638-643
Local destabilisation of a DNA double helix by a T–T wobble pair

A. G. Cornelis
Jeroen H.J. Haasnoot
Altona Cornelis
Research01 Sept 1979
Nature

Volume: 281, P: 235-236
Translation suppresses exogenous target RNA-mediated microRNA decay

Stable microRNAs (miRNAs) can undergo turnover via target-directed miRNA degradation (TDMD). Here, the authors show that TDMD triggers in non-coding regions degrade miRNAs more effectively than those in coding regions, where translation interferes with this process.

Tianqi Li
Lu Li
Mingyi Xie
ResearchOpen Access06 Jun 2025
Nature Communications

Volume: 16, P: 1-17
Transient Hoogsteen base pairs in canonical duplex DNA

The standard view of the genome is that the two DNA strands are linked by Watson–Crick base pairing. Some deviations from this canonical pairing have been observed when DNA is bound to a ligand. This paper now shows that naked DNA itself can transiently adopt a Hoogsteen base-pairing arrangement. This excited state base pairing provides a means to expand the chemistry and structure of DNA, and has implications for the binding of proteins to and repair of DNA.

Evgenia N. Nikolova
Eunae Kim
Hashim M. Al-Hashimi
Research26 Jan 2011
Nature

Volume: 470, P: 498-502

Search

Filter By:

Search

Quick links