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Showing 51–100 of 274 results

Advanced filters: Author: M. R. Issa Clear advanced filters

Ovarian cancer mutational processes drive site-specific immune evasion

Multi-modal analysis of genomically unstable ovarian tumours characterizes the contribution of anatomical sites and mutational processes to evolutionary phenotypic divergence and immune resistance mechanisms.

Ignacio Vázquez-García
Florian Uhlitz
Sohrab P. Shah
ResearchOpen Access14 Dec 2022
Nature

Volume: 612, P: 778-786
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer and appears to have a ‘selfish’ selective advantage.

Andrea Strakova
Thomas J. Nicholls
Elizabeth P. Murchison
ResearchOpen Access16 Jun 2020
Nature Communications

Volume: 11, P: 1-11
Hypermethylation of p15/ink4b/MTS2 gene is differentially implicated among non-Hodgkin’s lymphomas

B Martinez-Delgado
M Robledo
J Benitez
Research04 Jun 1998
Leukemia

Volume: 12, P: 937-941
Peripheral injury enhances central regeneration of primary sensory neurones

P. M. Richardson
V. M. K. Issa
Research28 Jun 1984
Nature

Volume: 309, P: 791-793
Clinical features and outcomes of newly diagnosed classical Hodgkin lymphoma patients in Saudi Arabia: a multicenter cohort study

Mai Alalawi
Abdullah M. Alrajhi
Khalid Al Sulaiman
ResearchOpen Access26 May 2025
Scientific Reports

Volume: 15, P: 1-11
Resource management for multi-drone communications in next-generation NOMA-enabled wireless networks

Sajed Ahmad
Syed Zain Ul Abideen
Teong Chee Chuah
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-17
RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia

Secondary acute myeloid leukemias (sAMLs) evolving from myeloproliferative neoplasms (MPNs) associate with poor prognosis. Here authors identify RSK1 as a vulnerability for MPN and sAML and show the efficacy of a first-in-class RSK inhibitor, PMD-026, against these types of myeloid malignancies.

Tim Kong
Angelo B. A. Laranjeira
Stephen T. Oh
ResearchOpen Access16 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

Al Ozonoff
Naresh Doni Jayavelu
Nadine Rouphael
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-17
Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder

GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.

Sukhleen Kour
Deepa S. Rajan
Udai Bhan Pandey
ResearchOpen Access07 May 2021
Nature Communications

Volume: 12, P: 1-15
Outcomes of adult patients with newly diagnosed IDH-mutated AML treated with intensive chemotherapy and venetoclax

Jennifer Croden
Wei-Ying Jen
Courtney D. DiNardo
Research14 Aug 2025
Leukemia

Volume: 39, P: 2538-2541
Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

AMPK regulates the metabolism and so drugs that activate AMPK might have potential for the treatment of metabolic disease. Here, the authors report the structure of AMPK bound to an activating compound, revealing two binding sites and indicating that dual therapy might be a good drug strategy.

Christopher G. Langendorf
Kevin R. W. Ngoei
Bruce E. Kemp
ResearchOpen Access08 Mar 2016
Nature Communications

Volume: 7, P: 1-8
Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa

N J Belshaw
G O Elliott
I T Johnson
ResearchOpen Access10 Jun 2008
British Journal of Cancer

Volume: 99, P: 136-142
A multi-objective improved horse herd optimizer based on convex lens imaging for stochastic optimization of wind energy resources in distribution networks considering reliability and uncertainty

Fude Duan
Ali Basem
Mustafa Okati
ResearchOpen Access27 Nov 2024
Scientific Reports

Volume: 14, P: 1-31
Methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines

A M O'Doherty
S W Church
I Hickey
Research08 Feb 2002
British Journal of Cancer

Volume: 86, P: 282-284
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

SNP rs17713054 in the 3p21.31 COVID-19 risk locus is identified as a probable causative variant for disease association. Chromatin conformation and gene expression data indicate that LZTFL1 is impacted by rs17713054 in pulmonary epithelial cells.

Damien J. Downes
Amy R. Cross
Jim R. Hughes
Research04 Nov 2021
Nature Genetics

Volume: 53, P: 1606-1615
Expression of p16INK4a/p16α and p19ARF/p16β is frequently altered in non-small cell lung cancer and correlates with p53 overexpression

Silvia Vonlanthen
Jim Heighway
Daniel C Betticher
Research24 Nov 1998
Oncogene

Volume: 17, P: 2779-2785
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

In this Resource, Buckley and colleagues profile patients with Crohn’s disease and ulcerative colitis before and after adalimumab therapy. Specific pretreatment differences in the epithelial and myeloid compartments were associated with remission outcomes in both diseases. The authors also describe the cellular circuitry in nonremission patients following treatment.

Tom Thomas
Matthias Friedrich
Christopher D. Buckley
ResearchOpen Access22 Oct 2024
Nature Immunology

Volume: 25, P: 2152-2165
Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours

M Murai
M Toyota
K Imai
ResearchOpen Access08 Mar 2005
British Journal of Cancer

Volume: 92, P: 1165-1172
Optimization of a photovoltaic/wind/battery energy-based microgrid in distribution network using machine learning and fuzzy multi-objective improved Kepler optimizer algorithms

Fude Duan
Mahdiyeh Eslami
Sivaprakasam Palani
ResearchOpen Access10 Jun 2024
Scientific Reports

Volume: 14, P: 1-26
Methylational urinalysis: a prospective study of bladder cancer patients and age stratified benign controls

D R Yates
I Rehman
J W F Catto
Research01 Mar 2006
Oncogene

Volume: 25, P: 1984-1988
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Sleep-Related Abdominal Muscle Behavior during Partial or Complete Obstructed Breathing in Prepubertal Children¹

J P Praud
A M D'allest
Cl Gaultier
Research01 Oct 1989
Pediatric Research

Volume: 26, P: 347-350
Epigenetic and genetic features of 24 colon cancer cell lines

D Ahmed
P W Eide
R A Lothe
ResearchOpen Access16 Sept 2013
Oncogenesis

Volume: 2, P: e71
An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts

The purity of synthetic mRNA is improved with a double-mutant T7 RNA polymerase.

Athanasios Dousis
Kanchana Ravichandran
Amy E. Rabideau
ResearchOpen Access10 Nov 2022
Nature Biotechnology

Volume: 41, P: 560-568
A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis

Jayastu Senapati
Muharrem Muftuoglu
Courtney D. DiNardo
ResearchOpen Access29 Jun 2023
Blood Cancer Journal

Volume: 13, P: 1-6
Arterial oxygen saturation over time and sleep studies in quadriplegic patients

C Cahan
B Gothe
K P Strohl
Research01 Mar 1993
Spinal Cord

Volume: 31, P: 172-179
Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival

Docosahexaenoic acid is a major and important retinal fatty acid that is recruited and retained in the photoreceptor membrane via an unknown mechanism. Here, Rice et al. show that adiponectin receptor 1 is a key molecular switch for docosahexaenoic acid membrane homeostasis and photoreceptor cell function.

Dennis S. Rice
Jorgelina M. Calandria
Nicolas G. Bazan
ResearchOpen Access04 Mar 2015
Nature Communications

Volume: 6, P: 1-15
Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis

Polyisoprenyl-glycosyltransferases (PI-GTs) catalyse the addition of sugar to lipid carriers, which is the first step in the production of sugar donors for glycosylation. Here Ardiccioni et al.present the structure of a bacterial PI-GT and propose a mechanistic basis for sugar transfer.

Chiara Ardiccioni
Oliver B. Clarke
Filippo Mancia
ResearchOpen Access05 Jan 2016
Nature Communications

Volume: 7, P: 1-9
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Cumulative effects of widespread landscape change alter predator–prey dynamics

Nicole P. Boucher
Morgan Anderson
Jason T. Fisher
ResearchOpen Access08 Jul 2022
Scientific Reports

Volume: 12, P: 1-11
Imminent loss of climate space for permafrost peatlands in Europe and Western Siberia

Permafrost peatlands are thawing, yet the timing and spatial dynamics of thaw are not well constrained. Under moderate and high warming scenarios, permafrost peatlands in Europe and Western Siberia will cross a tipping point where the climate becomes unsuitable, putting their carbon stores at risk.

Richard E. Fewster
Paul J. Morris
Christopher J. Smith
Research14 Mar 2022
Nature Climate Change

Volume: 12, P: 373-379
Treatment of sleep apnoea in spinal cord injured patients

M Biering-Sørensen
P W Norup
F Biering-Sørensen
Research01 May 1995
Spinal Cord

Volume: 33, P: 271-273
A microarray-based method for detecting methylated loci

I. Hatada
A. Kato
K. Matsubara
Research01 Aug 2002
Journal of Human Genetics

Volume: 47, P: 448-451
Consolidation during sleep of perceptual learning of spoken language

Kimberly M. Fenn
Howard C. Nusbaum
Daniel Margoliash
Research09 Oct 2003
Nature

Volume: 425, P: 614-616
A pharmacologenic rheostat for gene therapy

Insight into the molecular mechanism of rapamycin's immunosuppressive effects provides the basis for a novel approach to regulating therapeutic gene expression (pages 1028-1032).

James M. Wilson
News & Views01 Sept 1996
Nature Medicine

Volume: 2, P: 977-978
Alterations of p16 and p15 genes in acute leukemia with MLL gene rearrangements and their correlation with clinical features

H Ohnishi
SX Guo
Y Hayashi
Research01 Dec 1997
Leukemia

Volume: 11, P: 2120-2124
A novel WGF-LN based edge driven intelligence for wearable devices in human activity recognition

S. R. Menaka
M. Prakash
Arun Radhakrishnan
ResearchOpen Access19 Oct 2023
Scientific Reports

Volume: 13, P: 1-20
Comparative effectiveness of 6x R-CHOP21 versus 6x R-CHOP21 + 2 R for patients with advanced-stage diffuse large B-cell lymphoma

Carolien C. H. M. Maas
David van Klaveren
Avinash G. Dinmohamed
ResearchOpen Access12 Sept 2024
Blood Cancer Journal

Volume: 14, P: 1-9
Activation of the endocannabinoid system by organophosphorus nerve agents

Daniel K Nomura
Jacqueline L Blankman
John E Casida
Research27 Apr 2008
Nature Chemical Biology

Volume: 4, P: 373-378
Characteristics and outcomes of newly diagnosed acute myeloid Leukemia with KMT2A rearrangements

Alex Bataller
Hannah E. Goulart
Elias Jabbour
Research09 May 2025
Leukemia

Volume: 39, P: 1640-1649
An X-ray burst from a magnetar enlightening the mechanism of fast radio bursts

In April 2020, the AGILE satellite registered an X-ray burst temporally coincident with a radio burst from the Galactic magnetar SGR 1935+2154. As seen in hard X-rays, the burst was cut off above 80 keV and had an isotropically emitted energy of about 10⁴⁰ erg.

M. Tavani
C. Casentini
F. D’Amico
Research18 Feb 2021
Nature Astronomy

Volume: 5, P: 401-407
p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation

M Nakamura
K Sugita
S Nakazawa
Research12 Jun 1999
Leukemia

Volume: 13, P: 884-890
Effect of 677 C to T mutations in the methylenetetrahydrofolate reductase gene, folate intake and plasma homocysteine on adenoma recurrence

Maria Elena Martinez
Janine Einspahr
David S. Alberts
Research Highlights01 Apr 2001
Nature Genetics

Volume: 27, P: 72
Responses of Pulmonary Platelet-Derived Growth Factor Peptides and Receptors to Hyperoxia and Nitric Oxide in Piglet Lungs

Xiaoming Zhang
Patrick Reinsvold
William E Truog
Research01 Apr 2005
Pediatric Research

Volume: 57, P: 523-529
Insights into the pharmaceutical properties and in silico study of novel hydrazone derivatives

Hiba H. Ibraheem
Batool K. Queen
Ayman A. Swelum
ResearchOpen Access02 Dec 2024
Scientific Reports

Volume: 14, P: 1-18
A miniature multi-contrast microscope for functional imaging in freely behaving animals

Measuring multiple neurophysiologic variables usually requires bulky benchtop optical systems and working with anesthetized animals. Here the authors present a miniature portable microscope for neurovascular imaging in awake rodents, combining fluorescence, intrinsic optical signals and laser speckle contrast.

Janaka Senarathna
Hang Yu
Arvind P. Pathak
ResearchOpen Access09 Jan 2019
Nature Communications

Volume: 10, P: 1-13
Corrosion suppression and strengthening of the Al-10Zn alloy by adding silica nanorods

Eman AbdElRhiem
Yosry F. Barakat
Saad G. Mohamed
ResearchOpen Access08 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
G9a is essential for epigenetic silencing of K⁺ channel genes in acute-to-chronic pain transition

Chronic neuropathic pain is associated with K⁺ channel downregulation in primary sensory neurons. The authors show that G9a, a histone-modifying enzyme, is required for transcriptional repression of K⁺ channel–associated gene families caused by nerve injury. G9a in primary sensory neurons is a key epigenetic regulator involved in acute-to-chronic pain transition.

Geoffroy Laumet
Judit Garriga
Hui-Lin Pan
Research09 Nov 2015
Nature Neuroscience

Volume: 18, P: 1746-1755
Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis

Thymic epithelial tumors are associated with increased risk of immune checkpoint inhibitor (ICI)-induced myotoxicities, and the presence of anti-acetylcholine-receptor antibodies has the potential to serve as a biomarker for ICI-induced myocarditis in patients with cancer.

Charlotte Fenioux
Baptiste Abbar
Joe-Elie Salem
Research26 Oct 2023
Nature Medicine

Volume: 29, P: 3100-3110
Correlation of structure and function of the macula in patients with retinitis pigmentosa

R Battu
A Khanna
J S A G Schouten
Research08 May 2015
Eye

Volume: 29, P: 895-901

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