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Showing 1–8 of 8 results
Advanced filters: Author: Magnus T. Dillon Clear advanced filters

  • Oncolytic virus holds potential as a cancer therapy, but further optimization is desirable. Here the authors screen existing drug to find talazoparib, a PARP inhibitor, synergizing with reovirus type 3 Dearing (RT3D) to induce cancer cell apoptosis, anti-tumor immunity, as well as control of primary and rechallenge tumor in mouse models.

    • Joan Kyula-Currie
    • Victoria Roulstone
    • Kevin J. Harrington
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Immune checkpoint blockade can result in good outcomes in patients with metastatic head and neck squamous cell carcinoma (HNSCC), but not those with locally advanced disease. Here, the authors demonstrate that the addition of anti-NKG2A and anti-PD-L1 blockade to ATR inhibition and radiotherapy in the adjuvant setting can induce a robust antitumour immune response in mice.

    • Emmanuel C. Patin
    • Pablo Nenclares
    • Kevin J. Harrington
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Phylogeographical genomic analysis of Neisseria gonorrhoeae uncovers its recent emergence and current distribution into two distinct lineages that are differentially associated with antibiotic resistance and sexual networks.

    • Leonor Sánchez-Busó
    • Daniel Golparian
    • Simon R. Harris
    Research
    Nature Microbiology
    Volume: 4, P: 1941-1950

  • Gonorrhoea is a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae that affects millions of people worldwide, and its incidence is increasing in many settings. The emergence and spread of antimicrobial resistance in N. gonorrhoeae threatens to leave affected individuals with no effective treatments.

    • Magnus Unemo
    • H Steven Seifert
    • Jo-Anne R. Dillon
    Reviews
    Nature Reviews Disease Primers
    Volume: 5, P: 1-23

  • This Review focuses on the role of tumour cell-autonomous signalling after radiotherapy. It describes how radiotherapy, through its immunomodulating effects, might be combined with immune checkpoint inhibitors and other immunotherapies and how DNA damage response inhibitors in combination with radiotherapy may be used to further augment this approach.

    • Martin McLaughlin
    • Emmanuel C. Patin
    • Kevin J. Harrington
    Reviews
    Nature Reviews Cancer
    Volume: 20, P: 203-217

  • In the Review, Jensen and Unemo examine the epidemiology and clinical features, treatment options, and antimicrobial resistance of Neisseria gonorrhoeae and Mycoplasma genitalium, while briefly covering Chlamydia trachomatis and Treponema pallidum.

    • Jorgen S. Jensen
    • Magnus Unemo
    Reviews
    Nature Reviews Microbiology
    Volume: 22, P: 435-450