Arid1b haploinsufficiency causes autism and intellectual disability, yet the neurobiological basis of this is unknown. The authors demonstrate that Arid1b-heterozygous mice have impaired cortical interneuron development and epigenetic signatures. These mice also have cognitive and social deficits, which are reversed by treatment with a GABAA-receptor-positive allosteric modulator.
- Eui-Man Jung
- Jeffrey Jay Moffat
- Woo-Yang Kim
