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Mechanosensitive extrusion of Enterovirus A71-infected cells from colonic organoids

Enterovirus-infected cells are extruded from the apical surface of differentiated human colon organoids by a mechanical-force-dependent mechanism that preserves the uninfected host epithelium.

Jasmine Moshiri
Ailsa R. Craven
Karla Kirkegaard
ResearchOpen Access13 Mar 2023
Nature Microbiology

Volume: 8, P: 629-639
Accessible homeostatic gastric organoids reveal secondary cell type-specific host-pathogen interactions in Helicobacter pylori infections

Current knowledge of the mechanisms that underly Helicobacter pylori (H. pylori) infections remains limited. Here, the authors present an in vitro gastric model that combines structural complexity with experimental accessibility, enabling improved research into H. pylori-induced pathogenesis.

Moritz Hofer
Youlim Kim
Matthias P. Lutolf
ResearchOpen Access20 Mar 2025
Nature Communications

Volume: 16, P: 1-9
Stanley Falkow (1934-2018)

Microbe hunter who uncovered how bacteria cause disease.

Manuel R. Amieva
Comments & Opinion07 Jun 2018
Nature

Volume: 558, P: 190
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

A long-term culture method for organoids derived from single adult human lung cells is used to identify progenitor cells and study SARS-CoV-2 infection.

Ameen A. Salahudeen
Shannon S. Choi
Calvin J. Kuo
Research25 Nov 2020
Nature

Volume: 588, P: 670-675
An infection-induced oxidation site regulates legumain processing and tumor growth

Chemical proteomics analysis of human gastric cells revealed that infection with the stomach bacterium Helicobacter pylori decreases reactivity of legumain Cys219, which alters legumain processing and promotes xenograft tumor growth.

Yekaterina Kovalyova
Daniel W. Bak
Stavroula K. Hatzios
Research24 Mar 2022
Nature Chemical Biology

Volume: 18, P: 698-705
Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP)

ABP profiling identifies uncharacterized S. aureus serine hydrolases, including the surface-localized FphB, which processes lipid ester substrates and is required for infection in vivo. An FphB inhibitor reduces in vivo bacterial load.

Christian S. Lentz
Jessica R. Sheldon
Matthew Bogyo
Research16 May 2018
Nature Chemical Biology

Volume: 14, P: 609-617
Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis

Myofibroblast-derived R-spondin 3 orchestrates regeneration of antral stomach epithelium via Wnt signalling in Axin2⁺ stem cells.

Michael Sigal
Catriona Y. Logan
Thomas F. Meyer
Research16 Aug 2017
Nature

Volume: 548, P: 451-455
A spatial transcriptomic signature of 26 genes resolved at single-cell resolution characterizes high-risk gastric cancer precursors

Robert J. Huang
Ignacio A. Wichmann
Hanlee P. Ji
ResearchOpen Access25 Feb 2025
npj Precision Oncology

Volume: 9, P: 1-13
Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases

The polarity of gastrointestinal organoids is reversed to study epithelial biology and host–microbe interactions. Access to the apical surface of the epithelium is increased while preserving epithelial integrity and secretory and absorptive functions.

Julia Y. Co
Mar Margalef-Català
Manuel R. Amieva
Protocols18 Oct 2021
Nature Protocols

Volume: 16, P: 5171-5192

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Mechanosensitive extrusion of Enterovirus A71-infected cells from colonic organoids

Accessible homeostatic gastric organoids reveal secondary cell type-specific host-pathogen interactions in Helicobacter pylori infections

Stanley Falkow (1934-2018)

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

An infection-induced oxidation site regulates legumain processing and tumor growth

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP)

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis

A spatial transcriptomic signature of 26 genes resolved at single-cell resolution characterizes high-risk gastric cancer precursors

Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases

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