Nature Search

Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations

Glioblastoma is characterised by high levels of intratumoural heterogeneity and plasticity, hindering treatment. Here, the authors develop an analytical framework, scFOCAL, to predict the sensitivity of glioblastoma cell subpopulations to therapies based on reversal of disease transcriptional signatures to identify synergistic therapeutic combinations.

Robert K. Suter
Anna M. Jermakowicz
Nagi G. Ayad
ResearchOpen Access07 Jan 2026
Nature Communications

Volume: 17, P: 1-18
Queuosine is incorporated into precursor tRNA before splicing

tRNA modifications are essential for function, yet their timing relative to processing is unclear. Here, the authors show that queuosine and derivative modifications occur before splicing of pre-tRNA^Tyr, with cryo-EM confirming direct recognition by the QTRT1/2 complex.

Wei Guo
Igor Kaczmarczyk
Francesca Tuorto
ResearchOpen Access31 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Nucleotide-induced hyper-oligomerization inactivates transcription termination factor ρ

Bacterial transcription factor Rho (ρ) is a key regulator of transcription termination. Here, the authors show that Escherichia coli ρ forms inactive oligomers and filaments in the presence of stress-associated nucleotides (p)ppGpp and ADP.

Bing Wang
Nelly Said
Irina Artsimovitch
ResearchOpen Access15 Feb 2025
Nature Communications

Volume: 16, P: 1-16
Allogeneic mesenchymal stem cell therapy with laromestrocel in mild Alzheimer’s disease: a randomized controlled phase 2a trial

Single and multiple intravenous infusions with laromestrocel, an allogeneic cell therapy, is safe in patients with mild AD and may reduce the impact of cognitive decline and brain atrophy within 9 months of treatment.

Brian G. Rash
Kevin N. Ramdas
Joshua M. Hare
ResearchOpen Access10 Mar 2025
Nature Medicine

Volume: 31, P: 1257-1266
Perceived vulnerability to wildfire diverges from parcel-level hazard assessments: evidence from nordic Valley, Utah (USA)

Lauren Nicole Dupéy Larsen
Mark Brunson
Jordan W. Smith
ResearchOpen Access20 Dec 2025
Scientific Reports

Volume: 15, P: 1-12
ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Circulating cell-free DNA from patients is analyzed by ChIP-seq to reconstruct gene expression in human organs and tumors.

Ronen Sadeh
Israa Sharkia
Nir Friedman
Research11 Jan 2021
Nature Biotechnology

Volume: 39, P: 586-598
Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

Immunization of macaques with nanoparticle-conjugated receptor-binding domain of SARS-CoV-2 adjuvanted with 3M-052 and alum results in cross-neutralizing antibodies against bat coronaviruses, SARS-CoV and SARS-CoV-2 variants, and may provide a platform for developing pan-coronavirus vaccines.

Kevin O. Saunders
Esther Lee
Barton F. Haynes
Research10 May 2021
Nature

Volume: 594, P: 553-559
Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics

Single-molecule imaging of cell-free nucleosomes detects colorectal cancer with high accuracy and sensitivity.

Vadim Fedyuk
Nir Erez
Efrat Shema
Research08 Sept 2022
Nature Biotechnology

Volume: 41, P: 212-221
Group B Streptococcus Promotes Oxygen Radical-Dependent Thromboxane Accumulation in Young Piglets

Lori A Shook
Thomas H Pauly
Mark N Gillespie
Research01 Apr 1990
Pediatric Research

Volume: 27, P: 349-352
Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

Immune cells are shaped by the tissue environment, yet the states of healthy human T cells are mainly studied in the blood. Here, the authors perform single cell RNA-seq of T cells from tissues and blood of healthy donors and show its utility as a reference map for comparison of human T cell states in disease.

Peter A. Szabo
Hanna Mendes Levitin
Peter A. Sims
ResearchOpen Access17 Oct 2019
Nature Communications

Volume: 10, P: 1-16
Attention-deficit/hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that typically starts in childhood. This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of ADHD.

Stephen V. Faraone
Mark A. Bellgrove
Jan K. Buitelaar
Reviews22 Feb 2024
Nature Reviews Disease Primers

Volume: 10, P: 1-21
Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions

Toll-like receptors detect conserved microbial features to initiate host defence and are tightly regulated. Here the authors show that the orphan receptor interleukin-17 receptor D negatively regulates signalling downstream of Toll-like receptors to prevent excessive inflammation.

Mark Mellett
Paola Atzei
Paul N. Moynagh
Research26 Mar 2015
Nature Communications

Volume: 6, P: 1-15
Drought alters the structure and functioning of complex food webs

Climatic changes could transform rivers as drought becomes more frequent with potentially severe, but largely unknown, consequences at multispecies levels of organization. Now research shows experimentally how the intensification of drought may alter the underlying structure and functioning of freshwater food webs.

Mark E. Ledger
Lee E. Brown
Guy Woodward
Research09 Sept 2012
Nature Climate Change

Volume: 3, P: 223-227
Truncating mutations of MAGEL2 cause Prader-Willi phenotypes and autism

Christian Schaaf, Manuel Gonzalez-Garay and colleagues report the identification of four individuals with truncating mutations on the paternal allele of MAGEL2, a gene within the imprinted domain linked to Prader-Willi syndrome (PWS). The four individuals have PWS or PWS-related phenotypes, and all have autism.

Christian P Schaaf
Manuel L Gonzalez-Garay
Yaping Yang
Research29 Sept 2013
Nature Genetics

Volume: 45, P: 1405-1408
Author Correction: ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Ronen Sadeh
Israa Sharkia
Nir Friedman
Amendments and Corrections21 Jan 2021
Nature Biotechnology

Volume: 39, P: 642
Supervise the algorithms

Mark Buchanan
Comments & Opinion13 Jun 2023
Nature Physics

Volume: 19, P: 762
Exerkines in health, resilience and disease

Exerkines are signalling moieties that are released in response to acute and/or chronic exercise that exert their effects through endocrine, paracrine and/or autocrine pathways. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions.

Lisa S. Chow
Robert E. Gerszten
Michael P. Snyder
Reviews18 Mar 2022
Nature Reviews Endocrinology

Volume: 18, P: 273-289
Spontaneous Variability in Minute Ventilation Oxygen Consumption and Heart Rate of Low Birth Weight Infants

Karl Schulze
Ram Kairam
L S James
Research01 Aug 1981
Pediatric Research

Volume: 15, P: 1111-1116
DNA methylation governs the dynamic regulation of inflammation by apoptotic cells during efferocytosis

Clare A. Notley
Christine K. Jordan
Michael R. Ehrenstein
ResearchOpen Access07 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
PUF60 variants cause a syndrome of ID, short stature, microcephaly, coloboma, craniofacial, cardiac, renal and spinal features

Karen J Low
Morad Ansari
Sarah F Smithson
ResearchOpen Access22 Mar 2017
European Journal of Human Genetics

Volume: 25, P: 552-559
Three feasible strategies to minimize kidney injury in 'incipient AKI'

Acute kidney injury (AKI) is a growing problem in hospitalized patients and is associated with adverse outcomes. Recognizing renal injury earlier—at the stage of 'incipient AKI'—may enable renoprotective strategies to be initiated at a time when more kidney tissue is salvageable. In this article, the authors propose three strategies that may preserve kidney function and minimize further kidney injury in patients with 'incipient AKI'.

Mark A. Perazella
Steven G. Coca
Reviews07 May 2013
Nature Reviews Nephrology

Volume: 9, P: 484-490
Know before you go

Mark Kessel
Comments & Opinion07 Mar 2012
Nature Biotechnology

Volume: 30, P: 219-220
Quantum secured blockchain framework for enhancing post quantum data security

Nalavala Ramanjaneya Reddy
Supriya Suryadevara
Rajitha Kotoju
ResearchOpen Access23 Aug 2025
Scientific Reports

Volume: 15, P: 1-29
Oppositional defiant disorder

This Primer by Hawes and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of oppositional defiant disorder (ODD), a disruptive behaviour disorder that typically occurs in childhood. This Primer also discusses the effects of ODD across the lifespan and provides an overview of future research directions.

David J. Hawes
Frances Gardner
Graeme Fairchild
Reviews22 Jun 2023
Nature Reviews Disease Primers

Volume: 9, P: 1-17
Biogen's early Alzheimer's data raise hopes, some eyebrows

Mark Ratner
News12 May 2015
Nature Biotechnology

Volume: 33, P: 438
Rosuvastatin calcium

Jeremy Quirk
Mark Thornton
Peter Kirkpatrick
Comments & Opinion01 Oct 2003
Nature Reviews Drug Discovery

Volume: 2, P: 769-770
Utility of multicolor fluorescent in situ hybridization in clinical cytogenetics

Syed M Jalal
Mark E Law
Research01 Jul 1999
Genetics in Medicine

Volume: 1, P: 181-186
Fatal Lactic Acidosis in Infancy with a Defect of Complex III of the Respiratory Chain

Mark A Birch-Machin
Isobel M Shepherd
Douglass M Turnbull
Research01 May 1989
Pediatric Research

Volume: 25, P: 553-559
Author Correction: ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Ronen Sadeh
Israa Sharkia
Nir Friedman
Amendments and Corrections01 Mar 2021
Nature Biotechnology

Volume: 39, P: 642
1453 APNEA AND BRADYCARDIA DURING ORAL FEEDING IN TERM NEONATES

Oommen P Mathew
Mark L Clark
Maria L Pronske
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 353
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

Neurodegenerative disorders of ageing such as Alzheimer disease, Parkinson disease and Huntington disease are characterized by the presence of neurotoxic misfolded and aggregated proteins. One reason underlying the accumulation of these proteins is insufficient clearance by intracellular and extracellular pathways such as the autophagic–lysosomal network and the glymph system. This article reviews the potential for therapeutically enhancing the clearance of neurotoxic proteins to curtail the onset and slow the progression of neurodegenerative disorders of ageing.

Barry Boland
Wai Haung Yu
Mark J. Millan
Reviews17 Aug 2018
Nature Reviews Drug Discovery

Volume: 17, P: 660-688
Every islet matters: improving the impact of human islet research

The authors of this Perspective summarize the state of human islet research and compare available islet procurement methods, proposing strategies to increase collaboration and standardization to accelerate discoveries on diabetes.

Anna L. Gloyn
Mark Ibberson
Michele Solimena
Reviews11 Aug 2022
Nature Metabolism

Volume: 4, P: 970-977
Childhood stroke

This Primer summarizes the mechanisms, epidemiology, diagnosis and treatment of stroke in children (that is, stroke occurring in those aged between 29 days and 18 years).

Peter B. Sporns
Heather J. Fullerton
Moritz Wildgruber
Reviews24 Feb 2022
Nature Reviews Disease Primers

Volume: 8, P: 1-27
β-Nerve Growth Factor Levels in Newborn Cord Sera

Joseph Haddad
Véronique Vilge
Jean Mark
Research01 Jun 1994
Pediatric Research

Volume: 35, P: 637-639
Applications of behavioural genetics: outpacing the science?

Mark A. Rothstein
Comments & Opinion31 Aug 2005
Nature Reviews Genetics

Volume: 6, P: 793-798
NEXMIF encephalopathy: an X-linked disorder with male and female phenotypic patterns

Hannah Stamberger
Trine B. Hammer
Ingrid E. Scheffer
Research04 Nov 2020
Genetics in Medicine

Volume: 23, P: 363-373
Type 2 immunity in tissue repair and fibrosis

In this Review, the authors describe how type 2 immune responses drive tissue repair and fibrosis. They explain how these responses are crucial for repairing damaged tissue but can also lead to pathological outcomes if not properly regulated.

Richard L. Gieseck III
Mark S. Wilson
Thomas A. Wynn
Reviews30 Aug 2017
Nature Reviews Immunology

Volume: 18, P: 62-76
Variants in GNAI1 cause a syndrome associated with variable features including developmental delay, seizures, and hypotonia

Alison M. Muir
Jennifer F. Gardner
Heather C. Mefford
Research20 Jan 2021
Genetics in Medicine

Volume: 23, P: 881-887
Replicating genotype–phenotype associations

What constitutes replication of a genotype–phenotype association, and how best can it be achieved?

Stephen J. Chanock
Teri Manolio
Francis S. Collins
Special Features06 Jun 2007
Nature

Volume: 447, P: 655-660
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis

Vipavee Niemsiri
Sara Brin Rosenthal
John R. Kelsoe
ResearchOpen Access29 Mar 2023
Molecular Psychiatry

Volume: 29, P: 6-19
Surgical excision of subfoveal neovascular membranes

Mark T Benson
Andrew Callear
Stephen Beatty
Research01 Sept 1998
Eye

Volume: 12, P: 768-774
Psychometric properties of the emotional processing scale in individuals with psychiatric symptoms and the development of a brief 15-item version

Daniel Maroti
Erland Axelsson
Robert Johansson
ResearchOpen Access21 Jun 2022
Scientific Reports

Volume: 12, P: 1-10
Predicting asthma in preschool children at high risk presenting in primary care: development of a clinical asthma prediction score

Lonneke B van der Mark
Karina E van Wonderen
Patrick JE Bindels
Research05 Feb 2014
Primary Care Respiratory Journal

Volume: 23, P: 52-59
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Jenny van Dongen
Fiona A. Hagenbeek
Dorret I. Boomsma
ResearchOpen Access08 Jan 2021
Molecular Psychiatry

Volume: 26, P: 2148-2162
Accelerated cortical thinning within structural brain networks is associated with irritability in youth

Robert J. Jirsaraie
Antonia N. Kaczkurkin
Theodore D. Satterthwaite
Research02 Sept 2019
Neuropsychopharmacology

Volume: 44, P: 2254-2262
Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1

Tyler B. Johnson
Keegan Mechels
Jill M. Weimer
ResearchOpen Access01 Nov 2018
Scientific Reports

Volume: 8, P: 1-8
KAT6A Syndrome: genotype–phenotype correlation in 76 patients with pathogenic KAT6A variants

Joanna Kennedy
David Goudie
Ruth Newbury-Ecob
Research24 Sept 2018
Genetics in Medicine

Volume: 21, P: 850-860
The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression

Mark D. Long
Prashant K. Singh
Moray J. Campbell
ResearchOpen Access17 Aug 2018
Oncogene

Volume: 38, P: 421-444
Mapping quantitative trait loci in plants: uses and caveats for evolutionary biology

Rodney Mauricio
Reviews01 May 2001
Nature Reviews Genetics

Volume: 2, P: 370-381
Navigating parental disagreement: ethical analysis and a proposed approach

Alice C. Baker
Mark R. Mercurio
Reviews15 Oct 2024
Journal of Perinatology

Volume: 45, P: 1017-1022

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