Nature Search

The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway

Christian Haass
Cynthia A. Lemere
Dennis J. Selkoe
Research01 Dec 1995
Nature Medicine

Volume: 1, P: 1291-1296
Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95

Maria Passafaro
Carlo Sala
Morgan Sheng
Research01 Dec 1999
Nature Neuroscience

Volume: 2, P: 1063-1069
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Martin Citron
David Westaway
Dennis J. Selkoe
Research01 Jan 1997
Nature Medicine

Volume: 3, P: 67-72
Elliptic anisotropy measurement of the f₀(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A. Hayrapetyan
A. Tumasyan
A. Zhokin
ResearchOpen Access27 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

Michael K. Lee
David R. Borchelt
Sangram S. Sisodia
Research01 Jul 1997
Nature Medicine

Volume: 3, P: 756-760
Predicting response and survival in chemotherapy-treated triple-negative breast cancer

A Prat
A Lluch
E Alba
ResearchOpen Access07 Aug 2014
British Journal of Cancer

Volume: 111, P: 1532-1541
Selective responses of visual cortical cells do not depend on shunting inhibition

Rodney J. Douglas
Kevan A. C. Martin
David Whitteridge
Research14 Apr 1988
Nature

Volume: 332, P: 642-644
An allosteric inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells

This study reports adhibin, a synthetic carbazole that suppresses the migratory and adhesive properties of cancer cells by a mechanism of targeted RhoGAP class-IX myosin inhibition and selective RhoGTPase interference, both translating into migrastatic activity, opening other perspectives in cancer therapy and basic research.

Despoina Kyriazi
Lea Voth
Georgios Tsiavaliaris
ResearchOpen Access16 Nov 2024
Nature Communications

Volume: 15, P: 1-25
Cloning of the galactokinase cDNA and identification of mutations in two families with cataracts

Dwight Stambolian
Yunjun Ai
Derk J. Bergsma
Research01 Jul 1995
Nature Genetics

Volume: 10, P: 307-312
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Yi Luo
Brad Bolon
Robert Vassar
Research01 Mar 2001
Nature Neuroscience

Volume: 4, P: 231-232
High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer

E Brain
C Levy
P Fumoleau
ResearchOpen Access18 Oct 2011
British Journal of Cancer

Volume: 105, P: 1480-1486
Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer

Using genetically engineered models, Genovese and colleagues study patterns of convergent evolution in renal cancer, and pinpoint dysregulation of interferon signaling as a means of adaptation to chromosomal instability in metastatic progression.

Luigi Perelli
Federica Carbone
Giannicola Genovese
ResearchOpen Access26 Jun 2023
Nature Cancer

Volume: 4, P: 984-1000
Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression

Carleigh Nesbit
Whitney Martin
Laura Reinholdt
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation

Anne-Laure Mahul-Mellier
Melek Firat Altay
Hilal A. Lashuel
ResearchOpen Access26 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1-27
Observation of quantum entanglement with top quarks at the ATLAS detector

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s = 13 TeV and an integrated luminosity of 140 fb⁻¹.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access18 Sept 2024
Nature

Volume: 633, P: 542-547
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Martin Citron
Tilman Oltersdorf
Dennis J. Selkoe
Research17 Dec 1992
Nature

Volume: 360, P: 672-674
Alzheimer's disease: strategies for disease modification

Alzheimer's disease (AD) presents the largest unmet need in neurology. This article provides an overview of the rationale and the issues that underlie the different strategies for drug discovery in AD, with a focus on approaches aimed at slowing or halting disease progression.

Martin Citron
Reviews01 May 2010
Nature Reviews Drug Discovery

Volume: 9, P: 387-398
Cooperation of Striatin 3 and MAP4K4 promotes growth and tissue invasion

Analysis of the MAP4K4-STRN3 cooperation in medulloblastoma reveals its opposing regulation of Hippo activation and tissue invasion in cancer.

Jessica Migliavacca
Buket Züllig
Martin Baumgartner
ResearchOpen Access08 Aug 2022
Communications Biology

Volume: 5, P: 1-18
Observation of electroweak production of two jets and a Z-boson pair

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access09 Feb 2023
Nature Physics

Volume: 19, P: 237-253
Citrin mediated metabolic rewiring in response to altered basal subcellular Ca²⁺ homeostasis

Koshenov et al. investigate the regulation of basal mitochondrial bioenergetics and find that Ca²⁺ fluxes from ER-mitochondria contact sites control basal mitochondrial metabolism and energetics. The authors identify citrin as a primary regulator of this process and show that manipulation of Ca²⁺ dynamics can reprogram cellular and mitochondrial metabolism.

Zhanat Koshenov
Furkan E. Oflaz
Wolfgang F. Graier
ResearchOpen Access20 Jan 2022
Communications Biology

Volume: 5, P: 1-15
Integrins: masters and slaves of endocytic transport

How integrins are trafficked by endocytosis markedly affects their distribution and function. Recent studies examining the molecular mechanisms of integrin trafficking show that it affects the recycling of key signalling receptors to influence cellular processes such as cytokinesis, cell migration and tumour angiogenesis.

Patrick T. Caswell
Suryakiran Vadrevu
Jim C. Norman
Reviews01 Dec 2009
Nature Reviews Molecular Cell Biology

Volume: 10, P: 843-853
Measurement of the Higgs boson width and evidence of its off-shell contributions to ZZ production

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

A. Tumasyan
W. Adam
W. Vetens
ResearchOpen Access20 Oct 2022
Nature Physics

Volume: 18, P: 1329-1334
Observation of triple J/ψ meson production in proton-proton collisions

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

A. Tumasyan
W. Adam
W. Vetens
ResearchOpen Access19 Jan 2023
Nature Physics

Volume: 19, P: 338-350
Test of the universality of τ and μ lepton couplings in W-boson decays with the ATLAS detector

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access05 Jul 2021
Nature Physics

Volume: 17, P: 813-818
Search for charged-lepton-flavour violation in Z-boson decays with the ATLAS detector

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access01 Jul 2021
Nature Physics

Volume: 17, P: 819-825
A portrait of the Higgs boson by the CMS experiment ten years after the discovery

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

A. Tumasyan
W. Adam
A. Zhokin
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 60-68
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

Ten years after the discovery of the Higgs boson, the ATLAS experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 52-59
Alzheimer's disease: treatments in discovery and development

Martin Citron
Reviews28 Oct 2002
Nature Neuroscience

Volume: 5, P: 1055-1057
Strategies for disease modification in Alzheimer's disease

Martin Citron
Reviews01 Sept 2004
Nature Reviews Neuroscience

Volume: 5, P: 677-685
Reply to Matters Arising: In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson’s disease

Diana L. Price
Asma Khan
Anja-Leona Biere
ResearchOpen Access14 Mar 2024
npj Parkinson's Disease

Volume: 10, P: 1-2
DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies

Wei Meng
Christopher G. Fenton
Ruth H. Paulssen
ResearchOpen Access21 Mar 2024
Scientific Reports

Volume: 14, P: 1-12
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

Li-Bang Yang
Kristina Lindholm
Yong Shen
Correspondence01 Jan 2003
Nature Medicine

Volume: 9, P: 3-4
In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson’s disease

Diana L. Price
Asma Khan
Anja-Leona Biere
ResearchOpen Access17 Jul 2023
npj Parkinson's Disease

Volume: 9, P: 1-12
Author Correction: A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

G. Aad
B. Abbott
L. Zwalinski
Amendments and CorrectionsOpen Access18 Oct 2023
Nature

Volume: 623, P: E5
A community-led initiative to de-risk and advance Parkinson’s disease therapeutic targets

Alexandra Vaiana
Jonathan Behr
Gaia Skibinski
ReviewsOpen Access20 Jun 2025
npj Parkinson's Disease

Volume: 11, P: 1-8
Author Correction: A portrait of the Higgs boson by the CMS experiment ten years after the discovery

A. Tumasyan
W. Adam
A. Zhokin
Amendments and CorrectionsOpen Access18 Oct 2023
Nature

Volume: 623, P: E4
Publisher Correction: Observation of triple J/ψ meson production in proton-proton collisions

A. Tumasyan
W. Adam
W. Vetens
Amendments and CorrectionsOpen Access12 Dec 2023
Nature Physics

Volume: 20, P: 332
Publisher Correction: Observation of triple J/ψ meson production in proton-proton collisions

A. Tumasyan
W. Adam
W. Vetens
Amendments and CorrectionsOpen Access27 Feb 2023
Nature Physics

Volume: 19, P: 461

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