Nature Search

How the α-helix got its name

‘Alpha helix’ was not Linus Pauling’s first choice of a name for the protein structural motif. Egli and Zhang recount what the original name was, why it was changed and what is between the alpha helix and the DNA double helix.

Martin Egli
Shuguang Zhang
Research Highlights24 Jan 2022
Nature Reviews Molecular Cell Biology

Volume: 23, P: 165
Remembering a giant of chemical crystallography

Martin Egli
Shuguang Zhang
Correspondence05 Oct 2021
Nature

Volume: 598, P: 32
Crop asynchrony stabilizes food production

Lukas Egli
Matthias Schröter
Ralf Seppelt
Research09 Dec 2020
Nature

Volume: 588, P: E7-E12
Selenium modification of nucleic acids: preparation of phosphoroselenoate derivatives for crystallographic phasing of nucleic acid structures

Pradeep S Pallan
Martin Egli
Protocols22 Mar 2007
Nature Protocols

Volume: 2, P: 640-646
Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression

Valentina Tereshko
Marianna Teplova
Martin Egli
Research01 Oct 2001
Nature Structural Biology

Volume: 8, P: 899-907
First prediction of sequence-specific recognition of double-helix nucleic acids by proteins

Prior to introduction of the first DNA–protein structure, Ned Seeman et al. correctly conceived how proteins recognize specific sequences in double-helix nucleic acids.

Martin Egli
Shuguang Zhang
Research Highlights12 Jan 2022
Nature Reviews Molecular Cell Biology

Volume: 23, P: 166
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies

Göttingen minipigs genetically engineered to carry a mini-repertoire of human genes for immunoglobulin antibodies allow for the toxicological testing of human recombinant antibodies.

Tatiana Flisikowska
Jerome Egli
Antonio Iglesias
ResearchOpen Access22 Sept 2022
Nature Biomedical Engineering

Volume: 6, P: 1248-1256
The microbiota vault initiative: safeguarding Earth’s microbial heritage for future generations

Maria G. Dominguez-Bello
Dominik Steiger
Martin J. Blaser
ReviewsOpen Access27 Jun 2025
Nature Communications

Volume: 16, P: 1-6
Selenium modification of nucleic acids: preparation of oligonucleotides with incorporated 2′-SeMe-uridine for crystallographic phasing of nucleic acid structures

Pradeep S Pallan
Martin Egli
Protocols22 Mar 2007
Nature Protocols

Volume: 2, P: 647-651
Mutation-specific CAR T cells as precision therapy for IGLV3-21^R110 expressing high-risk chronic lymphocytic leukemia

The subset of chronic lymphocytic leukemia (CLL) expressing the IGLV3- 21R110 BCR light chain often shows an aggressive clinical course. Here the authors report the development and characterization of IGLV3-21R110- targeted CAR T cells, showing selective targeting and eradication of IGLV3- 21R110 expressing CLL cells.

Florian Märkl
Christoph Schultheiß
Mascha Binder
ResearchOpen Access02 Feb 2024
Nature Communications

Volume: 15, P: 1-14
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Base editors are effective and safe for cholesterol reduction in non-human primates.

Tanja Rothgangl
Melissa K. Dennis
Gerald Schwank
ResearchOpen Access19 May 2021
Nature Biotechnology

Volume: 39, P: 949-957
Enigmatic dinosaur precursors bridge the gap to the origin of Pterosauria

Lagerpetids, bipedal archosaurs that are thought to be related to dinosaurs, are instead a sister group to pterosaurs, and although they have no obvious flight adaptations they share numerous synapomorphies with pterosaurs across the entire skeleton.

Martín D. Ezcurra
Sterling J. Nesbitt
Max C. Langer
Research09 Dec 2020
Nature

Volume: 588, P: 445-449
Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant

Manipulating DNA repair pathways can be used to improve the outcomes of CRISPR-based genome editing. Here the authors derive an enhanced RAD18 variant that suppresses 53BP1 recruitment to DNA double-strand breaks to enhance homology-mediated repair.

Tarun S. Nambiar
Pierre Billon
Alberto Ciccia
ResearchOpen Access30 Jul 2019
Nature Communications

Volume: 10, P: 1-13
Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

Marianna Teplova
George Minasov
Martin Egli
Research01 Jun 1999
Nature Structural Biology

Volume: 6, P: 535-539
From paternalism to self-determination: examining evolving tribal-federal relationships and co-management arrangements through three case studies

Clarita Lefthand-Begay
Lauren Redmore
Monte Mills
ResearchOpen Access07 Jan 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-14
Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients

The diversity of ESBL-producing Klebsiella pneumoniae species complex and ESBL-Escherichia coli within patients is low and colonization with the same strain may persist for long periods. Authors utilise clinical and microbiological data from electronic health records to investigate genetic diversity of colonizing and infecting strains.

Lisandra Aguilar-Bultet
Ana B. García-Martín
Sarah Tschudin-Sutter
ResearchOpen Access21 Dec 2023
Nature Communications

Volume: 14, P: 1-14
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot

Li Su
Liqing Chen
Alexander Rich
Research01 Mar 1999
Nature Structural Biology

Volume: 6, P: 285-292
Ectomycorrhizal ecology is imprinted in the genome of the dominant symbiotic fungus Cenococcum geophilum

The ascomycete Cenococcum geophilum is a beneficial mycorrhizal symbiont found frequently on tree roots. Here the authors use comparative genomics and transcriptomics to define genomic signatures that differentiate the beneficial C. geophilumfrom its saprotrophic and pathogenic relatives.

Martina Peter
Annegret Kohler
Francis M. Martin
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-15
A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory

Cortical thickness has high heritability estimates and is known to be influenced by genetic factors. Here, Freytag and colleagues show that DNA methylation patterns of peripheral blood monocytes are also correlated with cortical thickness and memory performance in human.

Virginie Freytag
Tania Carrillo-Roa
Andreas Papassotiropoulos
ResearchOpen Access26 Apr 2017
Nature Communications

Volume: 8, P: 1-12
2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

Short interfering siRNAs—siRNAs—have therapeutic potential in the treatment of disease; however, their delivery to target tissues is difficult. Here, Wu et al. chemically modify siRNAs and show that this improves loading into the siRNA silencing machinery and thus efficacy in eliminating cancer cells in mice.

Sherry Y. Wu
Xianbin Yang
Anil K. Sood
Research12 Mar 2014
Nature Communications

Volume: 5, P: 1-12
Visualizing a biological clockwork's cogs

Recent structural studies of KaiA and KaiB, two bacterial biological clock proteins, mark the beginning of a new phase in the analysis of circadian clock mechanisms.

Carl H Johnson
Martin Egli
News & Views01 Jul 2004
Nature Structural & Molecular Biology

Volume: 11, P: 584-585
Global impacts of future cropland expansion and intensification on agricultural markets and biodiversity

The increase in needs for agricultural commodities is projected to outpace the growth of farmland production globally, leading to high pressure on farming systems in the next decades. Here, the authors investigate the future impact of cropland expansion and intensification on agricultural markets and biodiversity, and suggest the need for balancing agricultural production with conservation goals.

Florian Zabel
Ruth Delzeit
Tomáš Václavík
ResearchOpen Access28 Jun 2019
Nature Communications

Volume: 10, P: 1-10
Inconsistent measurement calls into question progress on electrification in sub-Saharan Africa

Electricity access statistics used to track progress against the Sustainable Development Goal 7.1 set by the United Nations have significant uncertainties, which may bring into question the electrification status of at least 87.2 million people in sub-Saharan Africa. Consequently, we call for a re-evaluation of the definitions of electricity access used by international organizations and the methodologies applied to calculate them.

Stephanie Hirmer
Julia Tomei
Martin Stringer
Comments & Opinion16 Sept 2024
Nature Energy

Volume: 9, P: 1046-1050
Committing to diversity in participants, participation and knowledge production: place-based insights from the community science of Soilsafe Aotearoa

E. L. Sharp
M. Kah
R. E. Turnbull
ResearchOpen Access27 Sept 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-13
Plasmid- and strain-specific factors drive variation in ESBL-plasmid spread in vitro and in vivo

Fabienne Benz
Jana S. Huisman
Sebastian Bonhoeffer
ResearchOpen Access04 Nov 2020
The ISME Journal

Volume: 15, P: 862-878
Defining lower limits of biodegradation: atrazine degradation regulated by mass transfer and maintenance demand in Arthrobacter aurescens TC1

Kankana Kundu
Sviatlana Marozava
Martin Elsner
ResearchOpen Access09 May 2019
The ISME Journal

Volume: 13, P: 2236-2251
Enhanced Sensitivity to Attenuation of Conditioned Reinstatement by the mGluR_2/3 Agonist LY379268 and Increased Functional Activity of mGluR_2/3 in Rats with a History of Ethanol Dependence

Peter R Kufahl
Rémi Martin-Fardon
Friedbert Weiss
Research31 Aug 2011
Neuropsychopharmacology

Volume: 36, P: 2762-2773
Update of a prediction model for postoperative shoulder stiffness after arthroscopic rotator cuff repair

Stojanov et al. updated and internally validated a prediction model for the occurrence of post-operative shoulder stiffness following primary arthroscopic rotator cuff repair in Switzerland. Their findings support the development of further prediction models for an evidence-based and individualized decision-making in orthopedics.

Thomas Stojanov
Soheila Aghlmandi
Laurent Audigé
ResearchOpen Access02 Oct 2025
Communications Medicine

Volume: 5, P: 1-8
High protection and transmission-blocking immunity elicited by single-cycle SARS-CoV-2 vaccine in hamsters

Martin Joseph Lett
Fabian Otte
Thomas Klimkait
ResearchOpen Access30 Oct 2024
npj Vaccines

Volume: 9, P: 1-16
An epigenetic blockade of cognitive functions in the neurodegenerating brain

Histone deacetylase 2 is shown to suppress genes involved in cognitive function epigenetically, potentially opening the door to treatments for Alzheimer’s and other neurodegenerative diseases by developing HDAC2-selective inhibitors.

Johannes Gräff
Damien Rei
Li-Huei Tsai
Research29 Feb 2012
Nature

Volume: 483, P: 222-226
Phenotypic heterogeneity driven by nutrient limitation promotes growth in fluctuating environments

Single-cell measurements of metabolic activities using NanoSIMS reveals that substrate limitation increases phenotypic heterogeneity in Klebsiella oxytoca metabolism, which allows cells to cope with nutrient fluctuations.

Frank Schreiber
Sten Littmann
Martin Ackermann
Research09 May 2016
Nature Microbiology

Volume: 1, P: 1-7
Soil weathering dynamics and erosion in a dry oceanic area of the southern hemisphere (Otago, New Zealand)

Gerald Raab
Markus Egli
Fabio Scarciglia
ResearchOpen Access17 Nov 2022
Scientific Reports

Volume: 12, P: 1-17
Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling

Daniela Egli-Spichtig
Martin Y. H. Zhang
Farzana Perwad
ResearchOpen Access17 Mar 2021
Scientific Reports

Volume: 11, P: 1-14
Exhaustive search for epistatic effects on the human methylome

Tobias Egli
Vanja Vukojevic
Annette Milnik
ResearchOpen Access20 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Distinguishing anthropogenic and natural contributions to coproduction of national crop yields globally

Matthias Schröter
Lukas Egli
Ralf Seppelt
ResearchOpen Access24 May 2021
Scientific Reports

Volume: 11, P: 1-8
Impact of breast-feeding and high- and low-protein formula on the metabolism and growth of infants from overweight and obese mothers

François-Pierre J. Martin
Sofia Moco
Philippe Steenhout
Research27 Dec 2013
Pediatric Research

Volume: 75, P: 535-543

Search

How the α-helix got its name

Remembering a giant of chemical crystallography

Crop asynchrony stabilizes food production

Selenium modification of nucleic acids: preparation of phosphoroselenoate derivatives for crystallographic phasing of nucleic acid structures

Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression

First prediction of sequence-specific recognition of double-helix nucleic acids by proteins

A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies

The microbiota vault initiative: safeguarding Earth’s microbial heritage for future generations

Selenium modification of nucleic acids: preparation of oligonucleotides with incorporated 2′-SeMe-uridine for crystallographic phasing of nucleic acid structures

Mutation-specific CAR T cells as precision therapy for IGLV3-21^R110 expressing high-risk chronic lymphocytic leukemia

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Enigmatic dinosaur precursors bridge the gap to the origin of Pterosauria

Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

From paternalism to self-determination: examining evolving tribal-federal relationships and co-management arrangements through three case studies

Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients

Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot

Ectomycorrhizal ecology is imprinted in the genome of the dominant symbiotic fungus Cenococcum geophilum

A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory

2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

Visualizing a biological clockwork's cogs

Global impacts of future cropland expansion and intensification on agricultural markets and biodiversity

Inconsistent measurement calls into question progress on electrification in sub-Saharan Africa

Committing to diversity in participants, participation and knowledge production: place-based insights from the community science of Soilsafe Aotearoa

Plasmid- and strain-specific factors drive variation in ESBL-plasmid spread in vitro and in vivo

Defining lower limits of biodegradation: atrazine degradation regulated by mass transfer and maintenance demand in Arthrobacter aurescens TC1

Enhanced Sensitivity to Attenuation of Conditioned Reinstatement by the mGluR_2/3 Agonist LY379268 and Increased Functional Activity of mGluR_2/3 in Rats with a History of Ethanol Dependence

Update of a prediction model for postoperative shoulder stiffness after arthroscopic rotator cuff repair

High protection and transmission-blocking immunity elicited by single-cycle SARS-CoV-2 vaccine in hamsters

An epigenetic blockade of cognitive functions in the neurodegenerating brain

Phenotypic heterogeneity driven by nutrient limitation promotes growth in fluctuating environments

Soil weathering dynamics and erosion in a dry oceanic area of the southern hemisphere (Otago, New Zealand)

Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling

Exhaustive search for epistatic effects on the human methylome

Distinguishing anthropogenic and natural contributions to coproduction of national crop yields globally

Impact of breast-feeding and high- and low-protein formula on the metabolism and growth of infants from overweight and obese mothers

Search

Quick links

Search

Filter By:

Search

Quick links