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Showing 1–50 of 136 results

Advanced filters: Author: Martin L. Sos Clear advanced filters

Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia

Martin Stanulla
Elke Schaeffeler
Matthias Schwab
ResearchOpen Access13 Mar 2021
Leukemia

Volume: 35, P: 2650-2657
First-in-human diagnostic study of hepatic steatosis with computed ultrasound tomography in echo mode

Stähli, Becchetti, Korta Martiartu et al. present a first-in-human evaluation of computed ultrasound tomography in echo mode to quantify the speed of sound in the liver. Estimated values show an excellent discriminative ability in distinguishing normal versus steatotic livers, with potential value in the non-invasive diagnosis of liver steatosis.

Patrick Stähli
Chiara Becchetti
Michael Jaeger
ResearchOpen Access09 Dec 2023
Communications Medicine

Volume: 3, P: 1-9
DNA topoisomerase V is a relative of eukaryotic topoisomerase I from a hyperthermophilic prokaryote

Alexe I. Slesarev
Karl O. Stetter
Sergei A. Kozyavkin
Research19 Aug 1993
Nature

Volume: 364, P: 735-737
Purified λ regulatory protein cII positively activates promoters for lysogenic development

Hiroyuki Shimatake
Martin Rosenberg
Research09 Jul 1981
Nature

Volume: 292, P: 128-132
Functional synapses between neurons and small cell lung cancer

Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

Vignesh Sakthivelu
Anna Schmitt
Filippo Beleggia
ResearchOpen Access10 Sept 2025
Nature

P: 1-11
Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria

Martin Eilers
Gottfried Schatz
Research17 Jul 1986
Nature

Volume: 322, P: 228-232
GvHD prophylaxis with tacrolimus, sirolimus, and mycophenolate mofetil after reduced intensity conditioning hematopoietic stem cell allogeneic transplantation

L. Lopez-Corral
C. Blázquez-Goñi
JA Pérez-Simón
ResearchOpen Access08 Apr 2025
Bone Marrow Transplantation

Volume: 60, P: 832-840
Gemtuzumab ozogamicin in first-line treatment of CBF-AML: insights from a retrospective multi-center analysis

Julian Ronnacker
Philippe J. Muller
Maher Hanoun
ResearchOpen Access21 Jul 2025
Leukemia

Volume: 39, P: 2174-2180
Demonstration of Super-X divertor exhaust control for transient heat load management in compact fusion reactors

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

B. Kool
K. Verhaegh
V. Zamkovska
ResearchOpen Access05 Sept 2025
Nature Energy

Volume: 10, P: 1116-1131
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

David Vetrie
Igor Vořechovský
David R. Bentley
Research01 Jan 1993
Nature

Volume: 361, P: 226-233
Bacterial transformation: distribution, shared mechanisms and divergent control

In this Review, Claverys and colleagues describe the divergent and common principles that govern the transformation process in phylogenetically distinct bacteria and discuss the potential role of imported DNA in generating genetic diversity. They also discuss how this information can be used for the prediction of new transformable species.

Calum Johnston
Bernard Martin
Jean-Pierre Claverys
Reviews10 Feb 2014
Nature Reviews Microbiology

Volume: 12, P: 181-196
Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine

Thomas Gilmore
G. Steven Martin
Research01 Dec 1983
Nature

Volume: 306, P: 487-490
Activation of human immunodeficiency virus type 1 by DNA damage in human cells

Kristoffer Valerie
Anne Delers
Martin Rosenberg
Research05 May 1988
Nature

Volume: 333, P: 78-81
Publisher Correction: Functional synapses between neurons and small cell lung cancer

Vignesh Sakthivelu
Anna Schmitt
Filippo Beleggia
Amendments and CorrectionsOpen Access19 Sept 2025
Nature

P: 1
Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles

Karen Hsiao
Stephen R. Dlouhy
Stanley B. Prusiner
Research01 Apr 1992
Nature Genetics

Volume: 1, P: 68-71
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome

This is an issue edsumm for ng1939. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence. It shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.

Marco Tartaglia
Len A Pennacchio
Bruce D Gelb
Research03 Dec 2006
Nature Genetics

Volume: 39, P: 75-79
Nonsense mutations in the C–terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours

Eitan Friedman
Pablo V. Gejman
Frank McCormick
Research01 Nov 1993
Nature Genetics

Volume: 5, P: 242-247
Binding of synaptotagmin to the α-latrotoxin receptor implicates both in synaptic vesicle exocytosis

Alexander G. Petrenko
Mark S. Perin
Thomas C. Südhof
Research05 Sept 1991
Nature

Volume: 353, P: 65-68
Global decoupling of functional and phylogenetic diversity in plant communities

Functional diversity and phylogenetic diversity are expected to be positively correlated. Here the authors show that the covariation between these metrics in vascular plant communities around the world is often either inconsistent or negative.

Georg J. A. Hähn
Gabriella Damasceno
Helge Bruelheide
Research03 Dec 2024
Nature Ecology & Evolution

Volume: 9, P: 237-248
Rate of nucleologenesis as a measure of gene activity

C. DE LA TORRE
M. E. FERNANDEZ-GOMEZ
G. GIMENEZ-MARTIN
Research01 Aug 1975
Nature

Volume: 256, P: 503-505
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

Shih-Feng Tsai
David I. K. Martin
Stuart H. Orkin
Research08 Jun 1989
Nature

Volume: 339, P: 446-451
Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation

By leveraging paired microbiome and human gene expression data from pediatric patients who underwent hematopoietic cell transplantation, distinct lung–immune system–microorganism interactions were identified as important drivers of fatal lung injury.

Matt S. Zinter
Christopher C. Dvorak
Joseph L. DeRisi
ResearchOpen Access23 May 2024
Nature Medicine

Volume: 30, P: 1982-1993
Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk

Targeted therapy of ErbB2-dependent tumours often provokes an adaptive response leading to reactivation of the PI3K/AKT pathway. Here the authors identify an ErbB3-independent compensatory mechanism comprising Ras/PI3K activation directly by ErbB2, and develop biparatopic panErbB inhibitors to block this mode of resistance.

Rastislav Tamaskovic
Martin Schwill
Andreas Plückthun
ResearchOpen Access03 Jun 2016
Nature Communications

Volume: 7, P: 1-18
The Werner syndrome protein is a DNA helicase

Matthew D. Gray
Jiang-Cheng Shen
Lawrence A. Loeb
Research01 Sept 1997
Nature Genetics

Volume: 17, P: 100-103
mRNA transcripts related to full-length endogenous retroviral DNA in human cells

Arnold B. Rabson
Paul E. Steele
Malcolm A. Martin
Research08 Dec 1983
Nature

Volume: 306, P: 604-607
Discovery of the widespread site-specific single-stranded nuclease family Ssn

Site-specific endonucleases that exclusively cut single-stranded DNA have hitherto never been described and constitute a barrier to the development of ssDNA-based technologies. Here the authors identify and characterize a family of such enzymes that could be the basis of innovative molecular tools.

Martin Chenal
Alex Rivera-Millot
Frédéric J. Veyrier
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-15
Quantifying local stability and noise levels from time series in the US Western Interconnection blackout on 10th August 1996

Martin Heßler and Oliver Kamps introduce a Bayesian open-source tool to quantify resilience from rednoised data, illuminating the intricate interplay between various scales of power grid models and the real timeline of technical events during the historic 1996 Western Interconnection blackout.

Martin Heßler
Oliver Kamps
ResearchOpen Access07 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

Mixed responses to targeted therapy within a patient are a clinical challenge. Here the authors show that TP53 loss-of-function cooperates with whole genome doubling which increases chromosomal instability. This leads to greater cellular diversity and multiple routes of resistance, which in turn promotes mixed responses to treatment.

Sebastijan Hobor
Maise Al Bakir
Charles Swanton
ResearchOpen Access13 Jun 2024
Nature Communications

Volume: 15, P: 1-21
Finding a balance in reduced toxicity hematopoietic stem cell transplantation for thalassemia: role of infused CD3+ cell count and immunosuppression

Barbara Meissner
Peter Lang
Rita Beier
ResearchOpen Access07 Feb 2024
Bone Marrow Transplantation

Volume: 59, P: 587-596
The Darwin Rise Hypothesis of the Biogeographical Dispersal of Marsupials

P. G. MARTIN
Research10 Jan 1970
Nature

Volume: 225, P: 197-198
The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

Raymond W. Sweet
Shiro Yokoyama
Mitchell Gross
Research20 Sept 1984
Nature

Volume: 311, P: 273-275
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I

Kinase inhibitors are widely used to treat cancer, however patients frequently develop resistance. Here, the authors investigate adaption mechanisms during drug persistence and show that stimulation of the innate immunity sensor RIG-I enhances cancer cell death when combined with kinase inhibition.

Johannes Brägelmann
Carina Lorenz
Martin L. Sos
ResearchOpen Access17 Sept 2021
Nature Communications

Volume: 12, P: 1-15
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Small molecules are developed that irreversibly bind to the common G12C mutant of K-Ras but not the wild-type protein; crystallographic studies reveal the formation of an allosteric pocket that is not apparent in previous Ras studies, and the small molecules shift the affinity of K-Ras to favour GDP over GTP.

Jonathan M. Ostrem
Ulf Peters
Kevan M. Shokat
Research20 Nov 2013
Nature

Volume: 503, P: 548-551
Generation and characterization of a ΔF508 cystic fibrosis mouse model

William H. Colledge
Benjamin S. Abella
Martin J. Evans
Research01 Aug 1995
Nature Genetics

Volume: 10, P: 445-452
One-step Cre-loxP organism creation by TAx9

Synthesis of one-step Cre-loxP integrated plasmids is enabled by inclusion of a short “TAx9” DNA sequence during cloning, facilitating single-plasmid, one-step conditional transgenesis, as shown here in the mouse and newt.

Martin Miguel Casco-Robles
Tomoki Echigoya
Chikafumi Chiba
ResearchOpen Access06 Mar 2025
Communications Biology

Volume: 8, P: 1-10
Role of IRS-2 in insulin and cytokine signalling

Xiao Jian Sun
Ling-Mei Wang
Morris F. White
Research14 Sept 1995
Nature

Volume: 377, P: 173-177
High-affinity binding sites for juvenile hormone I in the larval integument of Drosophila hydei

Gerhard Klages
Hans Emmerich
Martin G. Peter
Research17 Jul 1980
Nature

Volume: 286, P: 282-285
Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation

Robert M. Rapoport
Martin B. Draznin
Ferid Murad
Research10 Nov 1983
Nature

Volume: 306, P: 174-176
Multiple organ-reactive monoclonal autoantibodies

Martin V. Haspel
Takashi Onodera
Abner Louis Notkins
Research01 Jul 1983
Nature

Volume: 304, P: 73-76
Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Neutralizing antibodies (bNAbs) against HIV-1 are exclusively directed against the viral envelope protein (Env) and mainly target Env in a closed, prefusion state. Here, Yang et al. structurally characterize two heterologously-neutralizing CD4-binding site (CD4bs) antibodies isolated from sequentially immunized macaques, and show that these antibodies recognize the CD4bs on Env trimers in an „occluded-open‟ conformation between closed, as targeted by bNAbs, and fully-open, as recognized by CD4.

Zhi Yang
Kim-Marie A. Dam
Pamela J. Bjorkman
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-14
In vitro generation of B lymphocytes in mouse foetal liver, a mammalian ‘bursa equivalent’

JOHN J. T. OWEN
MAX D. Cooper
MARTIN C. RAFF
Research24 May 1974
Nature

Volume: 249, P: 361-363
Global protein turnover quantification in Escherichia coli reveals cytoplasmic recycling under nitrogen limitation

Gupta, Johnson et al. quantify the turnover rates of ~3200 E. coli proteins, demonstrating that cytoplasmic proteins are recycled when nitrogen is limited and that protein degradation rates are generally uncoupled from cell division rates.

Meera Gupta
Alex N. T. Johnson
Martin Wühr
ResearchOpen Access13 Jul 2024
Nature Communications

Volume: 15, P: 1-17
Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients

Jair Tenorio
Pablo Alarcón
Pablo Lapunzina
Research04 Nov 2019
European Journal of Human Genetics

Volume: 28, P: 469-479
Interaction between ATM protein and c-Abl in response to DNA damage

Timothy Shafman
Kum Kum Khanna
Martin F. Laving
Research29 May 1997
Nature

Volume: 387, P: 520-523
Expression of N-myc in teratocarcinoma stem cells and mouse embryos

Aya Jakobovits
Manfred Schwab
Gail R. Martin
Research14 Nov 1985
Nature

Volume: 318, P: 188-191
Safety and efficacy of G-CSF after allogeneic hematopoietic cell transplantation using post-transplant cyclophosphamide: clinical and in vitro examination of endothelial activation

Silvia Escribano-Serrat
Alexandra Pedraza
Maribel Díaz-Ricart
Research08 Aug 2024
Bone Marrow Transplantation

Volume: 59, P: 1466-1476
Aflatoxin B-oxide generated by chemical or enzymic oxidation of aflatoxin B₁ causes guanine substitution in nucleic acids

CARL N. MARTIN
R. COLIN GARNER
Research01 Jun 1977
Nature

Volume: 267, P: 863-865
Control of light emission of quantum emitters coupled to silicon nanoantenna using cylindrical vector beams

Photoluminescence of Eu³⁺-doped thin film on a silicon nanoring. The photoluminescence enhancement around the resonant nanoantenna mimics the near-field hot spots tailored by radially or azimuthally polarized cylindrical vector beam.

Martin Montagnac
Yoann Brûlé
Vincent Paillard
ResearchOpen Access19 Sept 2023
Light: Science & Applications

Volume: 12, P: 1-8
Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability

Charles Shaw-Smith
Alan M Pittman
Nigel P Carter
Research13 Aug 2006
Nature Genetics

Volume: 38, P: 1032-1037
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Oncogenic RAS mutants remain difficult to target with small molecules. Here, the authors show that RAS-binding Affimer proteins inhibit RAS signaling while binding diverse regions on the RAS surface, suggesting the potential to use Affimers as tools to identify new binding pockets and pharmacophores.

Katarzyna Z. Haza
Heather L. Martin
Darren C. Tomlinson
ResearchOpen Access30 Jun 2021
Nature Communications

Volume: 12, P: 1-15

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