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Dendritic cells experience cell shape changes while migrating within the complex physical environment of tissues. Sensing of these shape changes modifies their migratory properties and imprints these cells with immunoregulatory properties.

Using degron approaches, the authors show that cancer cells experiencing prolonged DNA methylation loss—without substantial DNA damage—undergo non-canonical senescence. This has important potential implications for cancer treatment.

The mechanisms by which pyruvate metabolism defects lead to neurological symptoms in Leigh syndrome patients remain unclear. Here, the authors show a link between pyruvate metabolism and translation fidelity that is important for brain development.

Severe COVID-19 is characterized by hyperinflammation, and there is a need for accurate predictive biomarkers of progression. Lehuen et al. demonstrate that patients with severe COVID-19 show a dramatic loss of MAIT cells, and those that do remain are in a highly activated state.

The Tabulae Paralytica, a compilation of four molecular atlases of spinal cord injury, provides a window into the pathobiology of spinal cord injury, establishing a framework for integrating multimodal, genome-scale measurements in four dimensions to study biology and medicine.

Dragwidge et al. report that the plant endocytic complex, the TSET–TPLATE complex, undergoes biomolecular condensation through interactions with plasma membrane phospholipids and recruits clathrin for endocytosis.

Genomic, transcriptomic and epigenetic analyses of malignant pleural mesothelioma identify molecular axes and specialized tumor profiles underlying intertumoral heterogeneity.

Bdelloid rotifers can withstand a wide range of genotoxic stresses. Here the authors reveal that a DNA ligase of bacterial origin was acquired by horizontal gene transfer to confer high resistance to ionizing radiation in bdelloid rotifers and other organisms known for their extreme tolerance to stress.

Glycosaminoglycans (GAGs) are highly anionic functional polysaccharides with subtle structural variations that are very difficult to differentiate. Here the authors demonstrate proof-of-concept single-molecule detection by nanopore, taking a first step towards the ultimate goal of GAG sequencing.

Organic peroxy radicals play a pivotal role in producing highly oxygenated organic molecules but the formation mechanisms remain elusive. Here, the authors show in-situ characterization of peroxy radicals and dimer structures in the gas-phase, using online tandem mass spectrometry analyses.

De novo assembly of 23 Aspergillus section Nigri and 6 Aspergillus niger genome sequences allows for inter- and intraspecies comparisons and prediction of secondary metabolite gene clusters.

Louis-Marie Lebas and colleagues present a method for fast 3D electron microscopy of sensitive samples in environmental conditions using custom software and hardware. It enables automated, low-dose imaging with high resolution and simple preparation.

Bathymetric surveys of the submarine Congo Canyon show damming by canyon-flank landslides led to the temporary storage of substantial masses of sediment and organic carbon, interrupting their transport to the deep sea.

SARS-CoV-2 evolved into several sublineages harboring different mutations in spike. Here, the authors isolate and characterize nine SARS-CoV-2 variants and show that EG.5.1.3 has highest fitness in nasal epithelial cells, while JN.1 shows lower affinity to ACE2 and higher immune evasion compared to BA.2.86.1.

Single-cell analysis of Drosophila development with Hi-M suggests that physical proximity between regulatory regions does not necessarily instruct transcriptional states. Multi-way analyses identify the existence of regulatory hubs that emerge before topologically associating domains.

This study uncovers the role of epigenetic H2A monoubiquitination in the mouse brain’s response to chronic cocaine use. It also identifies genetic variations in humans linked to H2A monoubiquitination, modifying susceptibility to cocaine addiction and aggression, and paving the way for tailored treatments.

Peripheral macrophages located along motor axons react differently to neurodegeneration compared to CNS microglia in ALS mice. Modifying peripheral macrophages suppresses proinflammatory microglial responses, shifting them toward neuronal support.

The size of cells fluctuates but there are limited experimental methods to measure live mammalian cell sizes. Here, the authors track single cell volume (FXm) over the cell cycle and generate a mathematical framework to compare size homeostasis in datasets ranging from bacteria to mammalian cells.

Colletotrichum tofieldiae is a beneficial root endophyte, whereas the closely related C. incanumis pathogenic. Here the authors compare the genomes and transcriptomes during host plant interaction and demonstrate that the host plant can respond differently to the beneficial endophyte according to phosphate status.

Topological properties are defined from singularities of the wave functions delocalised in the bulk of the material, but most experimental manifestations remain indirect. Here, the authors observe a wavefront dislocation as a direct evidence of the phase singularity of the delocalised wave functions in 1D microwave photonic insulators.

In Streptococcus pneumoniae, competence for genetic transformation is accompanied by a pause in growth. Here, Bergé et al. show that this pause is linked to the cell cycle via at least two pathways that impair peptidoglycan synthesis and preserve genomic integrity during transformation.

During non-REM sleep, the thalamus produces spindles and the cortex produces downstates, but the interaction between these two areas in these sleep phenomena is not understood. Here, authors describe the dynamic loop between the thalamus and cortex that organizes the production of spindles and downstates in the human brain.

A rare sub-population of people living with HIV-1 experience long-lasting viral remission after interrupting antiretroviral therapy and are considered post-treatment controllers. Here the authors characterise the humoral immune response to HIV-1 in a cohort of post-treatment controllers.

Catherine André, Judith Fischer and colleagues report that mutations in PNPLA1 cause congenital ichthyosis in humans and golden retriever dogs. Their findings suggest a role for PNPLA1 in the formation of the epidermal lipid barrier.

This paper investigates the stress levels and behavior of wild animals when approached by remote-operated vehicles versus humans for data collection in field research

This study identifies the proteins critical to fungal cellulosome assembly, characterizing the complex as evolutionarily chimeric — an independently evolved fungal complex co-opted catalytic activities from bacteria coexisting within the gut.

The sequencing and analysis of the banana genome is reported; these results inform plant phylogenetic relationships and genome evolution, and provide a resource for future genetic improvement of this important crop species.

The choice of the physical system that represents a qubit can help reduce errors. Encoding them in the quadrature space of a superconducting resonator leads to exponentially reduced bit-flip rates, while phase-flip errors increase only linearly.

Optimization of culturing techniques has allowed the identification of 1,057 prokaryotic species within the human gut microbiome repertoire, doubling the previous number of isolated species from the human gut.

Developments, challenges and opportunities in using two-dimensional materials for the next generation of non-volatile spin-based memory technologies are reviewed, and possible disruptive improvements are discussed.