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Here, the authors report chemical vapor deposition growth of metallic 1T-CrTe₂ ultrathin crystals with controlled thickness and long-range ferromagnetic ordering, and observe a monotonic increase of the Curie temperature with decreasing thickness.

Radioactive fails to get under the physicist’s skin. By Georgina Ferry

In this work, the researchers realize the current-induced motion of Néel type chiral domain walls via spin-transfer-torque in the pristine van der Waals ferromagnet Fe₃GeTe₂ and via spin-orbit-torques in heterostructures with platinum or tungsten.

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

Here the authors show that MRAP2 tunes the melanocortin-4 receptor by boosting its G-protein signaling while limiting β-arrestin2 interaction and destabilizing receptor oligomers, shaping appetite regulation.

Insulator-to-metal transitions induced by spontaneous magnetization above room temperature have rarely been observed. Here, the authors show that this transition, along with concurrent high-temperature ferrimagnetic order, is realized in the novel 3d/5d hybridized quadruple perovskite oxide CaCu₃Ni₂Os₂O₁₂.

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.

ParABS systems partition chromosomal DNA and low-copy plasmids in bacteria. Here, the authors elucidate the mode of interaction between ParA and ParB and clarify how ParB stimulates the ATPase activity of ParA to drive the segregation process.

Analyses of ancient human DNA show that cultural and political transformations in Central Europe during the second half of the first millennium ce were associated with movements of Slavic populations into Germany, Poland and Croatia.

Tau aggregation, a hallmark of Alzheimer’s disease, disrupts neuron structure. Aging weakens chaperone defenses like Hsp90. This study designs β-Hsp90, a small peptide mimicking Hsp90, to prevent Tau aggregation, offering promise for new amyloid disease drugs.

By combining left- and right-handed DNA-PAINT probes, Unterauer et al. achieve simple, robust, and highly multiplexed super-resolution. They show 13-plex neuronal maps, revealing nanoscale organization of cytoskeleton, organelles, and synapses.

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Imposing shear flow on a cell layer induces an ordering transition. Now it is shown that an intermediate phase of ordering occurs driven by an interplay between cellular activity and the aligning field.

This study introduces a data-driven framework that combines stochastic optimization, simulations, and neural networks to design shape-morphing magnetic soft materials. The approach enables complex 3D transformations, enhancing robotic functions.

Sensor failures and limited resolution challenge many complex systems. Here, authors develop a multimodal AI method to generate super-resolution of a sensor using other available sensors in the system, revealing hidden dynamics in fusion plasmas and enabling cost-effective, high-resolution diagnostics.

The interplay between nematic, antiferromagnetic order and superconductivity in the iron pnictide superconductors remains obscured. Here, Wang et al. demonstrate well-separated nematic and Neel transition temperatures near optimal superconductivity in NaFe_1−xNi_xAs and uncover local distortions which could account for rotational symmetry breaking common in iron pnictides.

The authors report on an experimental study of attosecond time delays of photoelectrons emitted from CO₂ molecules. This clarifies the role of internal dynamics of ions and ionelectron entanglement on the photoionization dynamics.

Multiple types of DNA damage can lead to mutations in normal cells, ultimately contributing to the development of cancer. Here, the authors redefine the spectrum of mutational signatures linked to a particular type of DNA damage to uncover the protective role of specialized DNA repair mechanisms.

The realization of the anomalous Hall effect in high-mobility two dimensional electron systems has so far remained elusive. Here, the authors observe its emergence in MgZnO/ZnO heterostructures and attribute it to skew scattering of electrons by localized paramagnetic centres.

In three dimensions, it is possible to have more complicated spin textures, one such example is a hybrid chiral skyrmion tube, where each end of the tube has skyrmions of opposite chirality. Here, Dohi, Bhukta, Kammerbauer and coauthors find that these skyrmion tubes exhibit a non-reciprocal skyrmion Hall effect.

Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.

Experiments under upper-tropospheric conditions map the chemical formation of isoprene oxygenated organic molecules (important molecules for new particle formation) and reveal that relative radical ratios control their composition

Despite the apparent simplicity of a H2O molecule, the mutual ferroelectric ordering of the molecules is unresolved. Here, the authors realize a macroscopic ferroelectric phase transition in a network of dipole-dipole coupled water molecules located in nanopores of gemstone.

Genomes of nine brown algal species with different sex determination systems show that U/V sex chromosomes evolved 450–224 Ma and show remarkable conservation of genes within the sex-determining region despite independent expansions of the sex locus in each lineage.

Although poly(vinylidene fluoride) is a well-known organic ferroelectric, its utilization in microelectronics has been hampered by the difficulty in obtaining uniform thin films. By exploiting a high-temperature deposition approach, smooth and thin films of the ferroelectric δ-phase polymorph of this material are now obtained, showing their potential for capacitors and non-volatile memories.

The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.

Ferroelectric orders hardly exist in liquid or ice state of water, despite its enormous molecular electrical polarizability. Here, Gorshunov et al. report incipient ferroelectricity in chains of interacting water molecules by placing them in the structural channels of a beryl crystal.

Ferromagnetic systems rarely display a large or non-saturating magnetoresistance, due to the low Fermi velocity of the predominant charge carrier. Here, the authors show that MnBi, a ferromagnet, bucks this trend, showing both large and non-saturating magnetoresistance, and high charge carrier motilities.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

New concepts for comparing the genomes of 27 naturally inbred Arabidopsis thaliana accessions provide essential insights into obtaining a less biased view of whole-genome polymorphism.

Spotiflow uses deep learning for subpixel-accurate spot detection in diverse 2D and 3D images. The improved accuracy offered by Spotiflow enables improved biological insights in both iST and live imaging experiments.

Chromatin “breathing” at DNA lesions is controlled by different waves of histone ADP-ribosylation.

Skutterudites are a family of materials whose properties make them appealing for studying thermoelectric, magnetic, heavy-fermion and superconducting effects, among many others. Through a combination of theoretical and experimental approaches, this study identifies 43 new skutterudite compounds.

Nonninger et al. identify the TFEB–TGFβ signaling axis as a regulator of stem cell resilience that protects against a senescence-like state during the adult diapause in Caenorhabditis elegans, a mechanism conserved in vertebrate aging and mammalian cancer.

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

High-performance magnets are essential for energy conversion, but rare earth dependence and brittleness limit their use. Here, authors develop a rare earth-free magnet with enhanced magnetic and mechanical properties by introducing nano-lamellar structures via thermo-magnetic processing.

Cells can form a rotating doublet. This rotation is driven by the symmetry breaking of myosin polarization in the cortices of the two cells.

Soft magnetic materials are critical components of electric motors, generators and transformers, however obtaining a material that is magnetically soft, but mechanically robust and stable at high temperature is very difficult. Here, Han et al succeed in combining these disparate properties by introducing ferromagnetic Widmanstätten patterned intermetallic precipitates into a ferromagnetic alloy matrix.

At low temperatures, the orbital degrees of freedom in insulating magnets normally do not fluctuate, leaving only magnetic behaviour. Measurements now suggest that in Pr₂Zr₂O₇, it is possible to reach a quantum regime of coupled spin–orbital dynamics.

WISDEM is a hybrid detector for simultaneous EEG and fMRI recordings without artifacts or crosstalk, which allows access to neural activity at high temporal and spatial resolution, respectively, as demonstrated in rats.

Helimagnetic materials host a twisted magnetic texture, realizing screws, cycloids, and cones. While helimagnets are common in three dimensional materials, layered van der Waals helimagnets are exceedingly rare. Here, Akatsuka et al. demonstrate conical ordering in the easily cleavable magnet DyTe3.

Targeting alterations in both the PI3K-AKT-mTOR and DNA repairs pathways has shown synergy in preclinical studies. Here, the authors a phase I/II clinical trial investigating the combination of Olaparib (PARP inhibitor), metronomic cyclophosphamide (chemotherapy) and metformin (PI3K-AKT-mTOR inhibitor) in patients with recurrent endometrial carcinoma.

Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis.

Magnetic Weyl semimetals in the 2D limit may behave like 2D Chern insulators and host the quantum anomalous Hall effect at high temperatures. Here, the authors report the observation of linearly dispersing topological states confined to the edges of the kagome Co₃Sn terraces in the magnetic Weyl system Co₃Sn₂S₂.

Adriaenssens et al. show that unlike soluble cargo receptors, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected flexibility in the selective autophagy machinery.

Heavier analogues of unsaturated organic molecules are of interest because of their bonding situation and their potential use in synthesis. Now, a Bi(I)-based allyl cation, which can be seen as a heavy congener of all-carbon π-allyl cations, has been reported. This complex serves as a synthon for Bi(I) transfer, enabling access to low-valent organobismuth compounds.

Here, a combination of forward genetics and genome-wide association analyses has been used to show that variation at a single genetic locus in Arabidopsis thaliana underlies phenotypic variation in vegetative growth as well as resistance to infection. The strong enhancement of resistance mediated by one of the alleles at this locus explains the allele's persistence in natural populations throughout the world, even though it drastically reduces the production of new leaves.

Despite exhibiting ferroelectric features, SrTiO₃ fails to display long-range polar order at low temperatures due to quantum fluctuations. An ultrafast X-ray diffraction experiment now probes polar dynamics of this material at the nanometre scale.

Biomolecular phase separation arises from collective molecular interactions and is emerging as a key theme for biological function. Here the authors propose a broadly applicable method to quantify these interactions based on compositional and energetic parameters.