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Showing 1–50 of 66 results

Advanced filters: Author: Mayumi Kanagawa Clear advanced filters

Host control of persistent Epstein–Barr virus infection

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
Research19 Feb 2026
Nature

P: 1-5
Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic poly peptide

Shinzo Oikawa
Mayumi Imai
Hisayuki Matsuo
Research21 Jun 1984
Nature

Volume: 309, P: 724-726
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Mayumi Tamari and colleagues report a genome-wide association study for adult asthma in a Japanese population. They identify three new asthma susceptibility loci.

Tomomitsu Hirota
Atsushi Takahashi
Mayumi Tamari
Research31 Jul 2011
Nature Genetics

Volume: 43, P: 893-896
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis

Haruo Ikeda
Jun Ishikawa
Satoshi Ōmura
ResearchOpen Access14 Apr 2003
Nature Biotechnology

Volume: 21, P: 526-531
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Lung adenocarcinoma cells respond differently to mechanical stress in 3D versus 2D environments

This study shows that lung adenocarcinoma cells respond differently to respiratory motion–mimicking mechanical stress in 3D compared with 2D environments, highlighting the need for 3D culture systems to better understand tumour mechanobiology.

Naoya Kitamura
Mayumi Iwatake
Tomoshi Tsuchiya
ResearchOpen Access11 Dec 2025
Communications Biology

Volume: 8, P: 1-14
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms

Yoshihiro Onouchi
Tomohiko Gunji
Akira Hata
Research16 Dec 2007
Nature Genetics

Volume: 40, P: 35-42
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency

Point mutations have been found in induced pluripotent stem cells (iPSCs) but when they arise is unclear. Here, the authors show that a G1/S cell cycle checkpoint deficiency transiently occurs early in genome reprogramming, suggesting a common developmental pathway between iPSC and tumorigenesis, and generate genetic burden-free human iPSCs.

Ryoko Araki
Yuko Hoki
Masumi Abe
ResearchOpen Access10 Jan 2020
Nature Communications

Volume: 11, P: 1-17
Rituximab-induced long-term remission in childhood-onset, uncomplicated, frequently relapsing or steroid-dependent nephrotic syndrome: a randomized, placebo-controlled trial and a follow-up study

Kazumoto Iijima
Mayumi Sako
Mari Oba
ResearchOpen Access10 Oct 2025
Scientific Reports

Volume: 15, P: 1-14
Girolline is a sequence context-selective modulator of eIF5A activity

The marine natural product girolline is an inhibitor of protein synthesis. Here, the authors show that girolline is a sequence-selective modulator of eIF5A that can cause ribosome stalling and activate ribosome-associated quality control.

Tilman Schneider-Poetsch
Yongjun Dang
Minoru Yoshida
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-13
Precise Synthesis of Regular and Asymmetric Star Polymers and Densely Branched Polymers with Starlike Structures by Means of Living Anionic Polymerization

Akira Hirao
Mayumi Hayashi
Sang Woog Ryu
Research01 Sept 2002
Polymer Journal

Volume: 34, P: 633-658
Non-reassuring foetal status and neonatal irritability in the Japan Environment and Children’s Study: A cohort study

Seiichi Morokuma
Takehiro Michikawa
Koichi Kusuhara
ResearchOpen Access26 Oct 2018
Scientific Reports

Volume: 8, P: 1-7
Source evaluation of ¹³⁷Cs in foodstuffs based on trace ¹³⁴Cs radioactivity measurements following the Fukushima nuclear accident

Mayumi Hori
Takuya Saito
Katsumi Shozugawa
ResearchOpen Access14 Nov 2018
Scientific Reports

Volume: 8, P: 1-6
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

Mayumi Ueta
Chitra Kannabiran
Shigeru Kinoshita
ResearchOpen Access07 Aug 2014
Scientific Reports

Volume: 4, P: 1-4
Conformational alteration of DOCK5•ELMO1 signalosome on lipid membrane

Membrane-flattened DOCK5–ELMO1–RhoG–Rac1 complexes reveal that conformational changes from hinge rotations and ELMO1 PH domain–lipid interactions cooperatively regulate DOCK5 GEF activity and downstream signalling.

Takehiro Shinoda
Kazushige Katsura
Mikako Shirouzu
ResearchOpen Access13 Nov 2025
Communications Biology

Volume: 8, P: 1-10
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

This study describes RK-701, an inhibitor of histone methyltransferases G9a/GLP, as a promising therapeutic candidate for sickle cell disease and a universal role of BGLT3 lncRNA in fetal hemoglobin reactivation by chemical inducers including RK-701.

Shohei Takase
Takashi Hiroyama
Akihiro Ito
ResearchOpen Access12 Jan 2023
Nature Communications

Volume: 14, P: 1-18
Impact of shared storybook reading on child development: The Japan Environment and Children’s Study

Haruhiko Nakamura
Tomohisa Suzuki
Kimitoshi Nakamura
ResearchOpen Access08 Jan 2026
Pediatric Research

P: 1-9
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Successive Synthesis of Well-Defined Star-Branched Polymers by Iterative Methodology Based on Living Anionic Polymerization

Akira Hirao
Kyouichi Inoue
Mayumi Hayashi
Reviews04 Jun 2008
Polymer Journal

Volume: 40, P: 923-941
A Rho-actin signaling pathway shapes cell wall boundaries in Arabidopsis xylem vessels

Cell wall pits allow movement of water between xylem vessels and are formed via Rho-GTPase mediated signaling that leads to local microtubule disassembly. Here, Sugiyama et al. show that an additional Rho-GTPase pathway controls cell wall deposition and actin dynamics to form pit boundaries.

Yuki Sugiyama
Yoshinobu Nagashima
Yoshihisa Oda
ResearchOpen Access28 Jan 2019
Nature Communications

Volume: 10, P: 1-10
Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Yukari Yada
Akihide Ohkuchi
Mariko Hida
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-13
Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum

GABAergic neuron progenitors in the cerebellum give rise to Purkinje cells and GABAergic interneurons. Here the authors show that the transcription factors Olig2 and Gsx1 regulate an identity transition from Purkinje cell progenitors to interneuron progenitors during mouse development.

Yusuke Seto
Tomoya Nakatani
Mikio Hoshino
Research18 Feb 2014
Nature Communications

Volume: 5, P: 1-13
Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana

Ammonium is an important nitrogen source for plants but excess ammonium impairs growth. Here the authors show that ammonium toxicity results from assimilation by GLUTAMINE SYNTHETASE 2 in the plastids which results in excess proton accumulation and acidity stress.

Takushi Hachiya
Jun Inaba
Hitoshi Sakakibara
ResearchOpen Access16 Aug 2021
Nature Communications

Volume: 12, P: 1-10
Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells

The molecular mechanisms determining the temporal identity patterns of self-renewing progenitors during cerebral development are largely unclear. Here, using single cell transcriptome analyses, the authors find progenitor temporal identity arises independent of cell-cycle progression and Notch activation.

Mayumi Okamoto
Takaki Miyata
Ayano Kawaguchi
ResearchOpen Access20 Apr 2016
Nature Communications

Volume: 7, P: 1-16
Accuracy of breathing and radial pulse assessment by non-medical persons: an observational cross-sectional study

Kensuke Suzuki
Ryoto Sakaniwa
Hiroyuki Yokota
ResearchOpen Access31 Jan 2023
Scientific Reports

Volume: 13, P: 1-7
Appetite loss and associated factors at 1 year after intensive care unit elder survivors in a secondary analysis of the SMAP-HoPe study

Mio Kitayama
Takeshi Unoki
Yoshiki Masuda
ResearchOpen Access19 Jan 2023
Scientific Reports

Volume: 13, P: 1-7
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
An organoid library unveils subtype-specific IGF-1 dependency via a YAP–AP1 axis in human small cell lung cancer

Sato and colleagues present a biobank of patient-derived SCLC organoids, conducting a comprehensive genome and transcriptome profiling that reveals the existence of NE and non-NE subtypes with distinct molecular dependencies.

Takahiro Fukushima
Kazuhiro Togasaki
Toshiro Sato
Research30 Apr 2025
Nature Cancer

Volume: 6, P: 874-891
The dynamics of carbon stored in xylem sapwood to drought-induced hydraulic stress in mature trees

Kenichi Yoshimura
Shin-Taro Saiki
Atsushi Ishida
ResearchOpen Access15 Apr 2016
Scientific Reports

Volume: 6, P: 1-8
Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement

Mayumi Ueta
Nahoko Kaniwa
Shigeru Kinoshita
ResearchOpen Access30 Apr 2014
Scientific Reports

Volume: 4, P: 1-6
Effects of venetoclax, a BCL2 inhibitor, in systemic chronic active Epstein-Barr virus disease

Ayaka Ohashi
Miwako Nishio
Ayako Arai
ResearchOpen Access27 May 2025
Scientific Reports

Volume: 15, P: 1-13
Neuromedin U-deficient rats do not lose body weight or food intake

Kyoka Yokogi
Yuki Goto
Sayaka Aizawa
ResearchOpen Access27 Oct 2022
Scientific Reports

Volume: 12, P: 1-14
Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells

Shinichi Kanno
Nobuyuki Oda
Yasufumi Sato
Research15 May 2000
Oncogene

Volume: 19, P: 2138-2146
Association of serum uric acid with subsequent arterial stiffness and renal function in normotensive subjects

Shiori Nagano
Maasa Takahashi
Mikio Arita
Research16 Feb 2017
Hypertension Research

Volume: 40, P: 620-624
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

Andre Franke and colleagues perform an association study of atopic dermatitis based on high-density genotyping using the Immunochip array. They identify four new susceptibility loci for this common inflammatory skin disease.

David Ellinghaus
Hansjörg Baurecht
Stephan Weidinger
Research02 Jun 2013
Nature Genetics

Volume: 45, P: 808-812
A survey of monitoring tap water hardness in Japan and its distribution patterns

Mayumi Hori
Katsumi Shozugawa
Yuichiro Watanabe
ResearchOpen Access29 Jun 2021
Scientific Reports

Volume: 11, P: 1-13
Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling

Yusuke Baba
Yoshiro Maezawa
Koutaro Yokote
ResearchOpen Access02 Aug 2025
Scientific Reports

Volume: 15, P: 1-15
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing

Ken Nakatani
Mayumi Ueta
Katsushi Tokunaga
ResearchOpen Access07 Nov 2019
Scientific Reports

Volume: 9, P: 1-8
Data sharing ethics toolkit: The Human Cell Atlas

The human cell atlas (HCA) is intended as an exhaustive guidebook of human cell types and their properties. Here Kirby et al. outline how the HCA Ethics Working Group is working to build a solid foundation to address the complexities of data collection and sharing.

Emily Kirby
Alexander Bernier
Bartha M. Knoppers
ReviewsOpen Access20 Nov 2024
Nature Communications

Volume: 15, P: 1-7
Targeting Ras-binding domain of ELMO1 by computational nanobody design

Structural analysis of the Ras-binding domain (RBD) of ELMO1 alone and in complex with the activator RhoG enables rational engineering and validation of a nanobody targeting ELMO1 RBD.

Chunlai Tam
Mutsuko Kukimoto-Niino
Kam Y. J. Zhang
ResearchOpen Access17 Mar 2023
Communications Biology

Volume: 6, P: 1-11
Loss of nocturnal decline of blood pressure in non-diabetic patients with nephrotic syndrome in the early and middle stages of chronic kidney disease

Daisaku Andoh
Mayumi Kobayashi
Satoshi Umemura
Research20 Mar 2009
Hypertension Research

Volume: 32, P: 364-368
Visit-to-visit variability of blood pressure and cardiovascular events among the working-age population in Japan: findings from the Japan Epidemiology Collaboration on Occupational Health Study

Yosuke Inoue
Keisuke Kuwahara
Rika Osawa
Research14 May 2021
Hypertension Research

Volume: 44, P: 1017-1025
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells

Satoru Shinriki
Mayumi Hirayama
Hirotaka Matsui
ResearchOpen Access14 Oct 2022
Leukemia

Volume: 36, P: 2605-2620

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