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Human serum albumin (HSA) can be used as a drug delivery material for cancer therapy. Here, the authors report an HSA-based photothermal platform that improves drug loading and photothermal therapeutic performance in breast cancer mouse models.

Reactive oxygen species (ROS)-based nanocatalytic cancer therapy is hindered by insufficient substrates at the tumor site and potential side effects arising from metabolites. Here the authors report a violet phosphorus-based nanosystem that supplies catalysts and substrates for producing cytotoxic ROS and generates the degradation products that can promote tumor calcification.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

NCOMMS-23-46799C Keratoconus can be effectively stabilized by corneal crosslinking (CXL), but the depletion of stromal oxygen limits the efficiency of CXL photochemical reactions. Here the authors address this issue by developing biocompatible graphitic carbon nitride quantum dots- based oxygen self-sufficient platforms.

Homochiral molecular capsules offer potential applications in chiral separation and stereospecific catalysis. Here, by pre-resolution of Δ/Λ-metalloligand precursors, the authors are able to assemble enantiopure supramolecular cages capable of stereoselective host-guest behaviour.

The authors establish the concept of time-defect topological modes, which are induced by the interplay between temporal defects and Floquet topology. Intriguingly, the realized time-defect topological modes exhibit spatial localization at the temporal defect, despite homogeneous lattice couplings across it.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

A haplotype-resolved genome of hybrid sugarcane cultivar XTT22 and population analyses of Saccharum accessions highlight the genome evolution of allopolyploids and provide opportunities for sugarcane breeding.

The immune suppressive tumour microenvironment drives recurrence and metastatic disease in prostate cancer. Here authors provide a detailed analysis of the microenvironment via single cell RNA sequencing and high-resolution spatial transcriptomics to identify tumour-dependent changes compared to healthy tissue.

EBV (Epstein-Barr virus)-targeted therapy is limited by efficient agents inducing lytic cycle in cancer cells. Here they report a transcriptional activator incorporated into lipid nanoparticles that could specifically activate endogenous BZLF1 and induce lytic reactivation in EBV-positive cancer cells thereby suppress tumor progression.

Hu, Tan, Chia et al. identify negative elongation factor A as one of the earliest drivers of the mouse embryonic 2-cell-like state through interaction with Top2a, which mediates Dux expression.

The identification of synthetic essential genes of PTEN is of therapeutic potential for PTEN-deficient prostate cancers. Here, the authors show that ARID4B is a synthetic essential gene in these cancers in which deficiency of PTEN prompts the AKT-ARID4B feedback loop required for activation of the PI3K-AKT signaling pathway.

A strategy using engineered functional customized viral receptors enables the development of functional infection models for coronaviruses whose native cellular receptors are unknown.

Wood-based electronics are typically constrained in their ability to undergo complex shape deformation. Here, authors integrate transparent wood film and cellulose-based conductive ink for flexible electronic origami devices that have been demonstrated as a proof-of-concept for human motion sensors.

Microwell-seq is used to generate single-cell, whole-body expression landscapes of zebrafish, Drosophila and earthworm. A deep-learning model, Nvwa, predicts gene expression from DNA sequence and identifies regulatory programs shared across eight species.

Tumor-derived extracellular vesicles (EVs) critically regulate tumor development and progression. Here the authors show that, in a mouse model of breast cancer, miR-9-5p-loaded EVs promote cholesterol biosynthesis and conversion into the oncometabolite 25-hydroxycholesterol, favoring immune evasion and promoting liver metastasis.

Most metamaterial experiments occur in bulk transmission geometries. Here researchers demonstrate integrated in-plane zero-index metamaterials.

Skp2 forms part of the SCF complex—an E3 ubiquitin ligase. Here the authors identify macroH2A1 as a novel target of Skp2 and propose an axis of regulation involving Skp2-macroH2A1-CDK8-p27 in cancer.

Itch is known to involve the parabrachial nucleus, but the following transmission nodes remain elusive. Here, the authors show in male mice that the central medial thalamic nucleus—medial prefrontal cortex (mPFC) pathway transmits itch signals and is involved in both acute scratching and chronic itch-related affective behavior, with an altered excitatory/inhibitory balance in mPFC in chronic itch models.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Yu and colleagues present a single-cell transcriptomic landscape of olfactory neuroblastoma, characterizing different tumor subtypes and cancer cell responses to drug treatments.

A nanofluidic chemoelectrical generator utilizing the Coulomb drag effect is developed to achieve enhanced current density, generating an amplified current of 1.2 mA cm⁻² and voltage of approximately 0.8 V, scalable linearly to tens of Volts.

The number of edge channels in quantum anomalous Hall insulators is controlled by varying either the magnetic dopant concentration or the interior spacer layer thickness, yielding Chern numbers up to 5.

Genetic variants can affect protein function and promote tumour progression by driving aberrant subcellular localization. Here, the authors characterise potential shuttling-attacking mutations (SAMs) across cancers using a deep learning model and experimental validation, and find how SAMs disrupt critical signalling interactions involved in cancer progression.

Support Brønsted acid strength and density play important kinetically relevant roles in low temperature NH3-SCR over Cu-exchanged small pore zeolite catalysts. Here the authors demonstrate Brønsted acid sites facilitate hydrolysis and intercage transfer of Cu^II(NH₃)₄ intermediates.

Through surveying 808 angiosperm genomes, this study reveals that the two-tiered plant immune receptor repertoires display hierarchically adaptive reduction during plant adaptation to special lifestyles or habitats with low pathogen burdens.

As immune checkpoint therapy is more frequently used for cancer, side effects such as Stevens-Johson syndrome / toxic epidermal necrolysis (SJS/TEN) are becoming more common. Here the authors use single cell transcriptomics to implicate TNF and CXCL10 in recruitment of CXCR3⁺ cytotoxic T cell in SJS/TEN skin lesions.

Developing depolymerizable and recyclable polymers with high light-emitting efficiencies is of vital importance for sustainable photonic technologies, but remains challenging. Here the authors design a strategy to develop such polymers based on the use of controllable cleavable moiety.

The non-canonical C-term-phosphorylation of eIF2α mediated by SPA protein kinases plays a significant positive role in eIF2 ternary complex formation and light-induced translation during photomorphogenesis.

Large strain gradient is crucial for flexoelectricity. Here, the authors reveal the generality and tunability of large strain gradients at grain boundaries in oxides, explaining the possible effects on the electrical activities of ceramics.

DNA methylation is critically involved in X chromosome inactivation (XCI) and dosage compensation, yet some X-chromosomal genes escape XCI. Here, Lujik et al. identify three autosomal genetic loci that associate with differential DNA methylation near genes that variably escape XCI in females.

Lin and colleagues report that hypoxia induces TRAF6-dependent mono-ubiquitylation of histone H2AX, which promotes binding and stabilization of HIF1α. Activated HIF1α signalling in turn promotes tumorigenesis and metastasis.

Colorectal cancer patients with mismatch repair-deficient, but not MMR-proficient tend to benefit from immune checkpoint blockade therapy. Here, the authors identify interactions among tumor and immune cells that are associated with the responsiveness to immunotherapy in colorectal cancer.

The momentum transport dynamics of a vaporizing droplet under low pressures remain undiscovered. Here authors report the vaporization momentum resulting from the intensive vaporization on the free surface of the water droplet contributes to the self-detachment of freezing droplets.

Quantum simulators should be able to give insight on exotic physics models such as supersymmetric extensions of Standard Model. Here, the authors demonstrate a first step in this direction, realising a prototypical SUSY model (and spontaneous SUSY breaking within it) using a trapped ion quantum simulator.