Nature Search

Integrating trade-offs and supply-demand into ecosystem service zoning management to provide more targeted management strategies from the water-food-ecosystem nexus perspective

Menghao Yang
Ming Wang
Haipeng Zhang
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-16
Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet’s disease

Behçet’s disease (BD) is characterized by polymorphonuclear neutrophils (PMN) and macrophage activation, but their interaction remains elusive. The authors here find PMN exosomes from BD patients are attenuated in suppressing proinflammatory macrophages when cocultured in vitro with the mechanism of decreased miR-122-5p/IRF5/TLR4 signaling and IFN-β autocrine pathway.

Xin Yu
Menghao Zhang
Wenjie Zheng
ResearchOpen Access02 Sept 2025
Nature Communications

Volume: 16, P: 1-13
Author Correction: TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease

Menghao Zhang
Na Kang
Wenjie Zheng
Amendments and CorrectionsOpen Access03 Jan 2025
Nature Communications

Volume: 16, P: 1
TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease

TNF inhibitors show clinical benefits for Behçet’s disease (BD), but the underlying molecular insights are still unclear. Here the authors use both patient samples and mouse genetic models to show that TNF inhibitors may target a metabolite/TRPM2/calcium signaling positive feedback loop of inflammation amplification for dampening vasculitis in BD.

Menghao Zhang
Na Kang
Wenjie Zheng
ResearchOpen Access26 Oct 2024
Nature Communications

Volume: 15, P: 1-17
A family of dual-anion-based sodium superionic conductors for all-solid-state sodium-ion batteries

All-solid-state sodium-ion batteries are promising candidates for grid-scale energy storage, but they require superior solid-state electrolytes (SSEs). Here sodium-ion SSEs based on dual-anion frameworks of oxychloride are studied and found to show high ionic conductivity and electrochemical oxidative stability with mechanical softness.

Xiaoting Lin
Shumin Zhang
Xueliang Sun
ResearchOpen Access01 Oct 2024
Nature Materials

Volume: 24, P: 83-91
DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes

hNEIL1 (human endonuclease VIII-like 1) is a broadly specific DNA glycosylase for base excision repair. Here, the authors show that hNEIL1 can assume activated or triage conformations: the structural basis for the mechanism that enables broad specificity and reduces futile repair of normal bases.

Menghao Liu
Jun Zhang
Chengqi Yi
ResearchOpen Access05 Jul 2021
Nature Communications

Volume: 12, P: 1-12
Author Correction: Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models

Wenhui Li
Xianyue Jiang
Qi Liu
Amendments and CorrectionsOpen Access09 Jan 2025
Nature Communications

Volume: 16, P: 1
Bevel-edge epitaxy of ferroelectric rhombohedral boron nitride single crystal

Centimetre-sized single-crystal rhombohedral boron nitride layers are achieved through bevel-edge epitaxy, and the resulting material exhibits robust, homogeneous and switchable ferroelectricity with a high Curie temperature.

Li Wang
Jiajie Qi
Xuedong Bai
Research01 May 2024
Nature

Volume: 629, P: 74-79
Stabilization of layered lithium-rich manganese oxide for anion exchange membrane fuel cells and water electrolysers

The development of superior and cost-effective catalysts for the oxygen reduction and evolution reactions is pivotal for the future hydrogen economy. Now a series of Ru-modified Li₂MnO₃ catalysts have been designed to optimize the electronic structure and achieve a high performance in both oxygen reduction and evolution reactions, as demonstrated in practical anion exchange membrane fuel cell and water electrolyser tests.

Xuepeng Zhong
Lijun Sui
Jiwei Ma
Research12 Apr 2024
Nature Catalysis

Volume: 7, P: 546-559
Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models

Identification of CRISPR-Cas systems by sequence alignment is limited by homolog sequence diversity. Here, the authors develop CHOOSER, and AI framework, for alignment free discovery of CRISPR-Cas systems, including EphcCasλ, which was validated for self-processing and DNA cleavage.

Wenhui Li
Xianyue Jiang
Qi Liu
ResearchOpen Access19 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Malleable, printable, bondable, and highly conductive MXene/liquid metal plasticine with improved wettability

This work offers a convenient method (solvent-assisted dispersion) for assembling liquid metals with MXene and other low-dimensional materials, paving a path for the development of multifunctional soft devices.

Haojie Jiang
Bin Yuan
Wei Lu
ResearchOpen Access20 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA

A genome-wide uracil profiling technology (termed “dU-seq”), based on selective labeling and biotin pull-down, reveals that uracil is enriched at the centromere of the human genome.

Xiaoting Shu
Menghao Liu
Chengqi Yi
Research21 May 2018
Nature Chemical Biology

Volume: 14, P: 680-687
METTL3-dependent m⁶A modification programs T follicular helper cell differentiation

T follicular helper (T_FH) cells are specialized effector CD4⁺ T cells that are critical in humoral immunity, but the function of post-transcriptional regulation is not clearly defined. Here, the authors demonstrate that RNA methylation is important for T_FH effector differentiation and subsequent antibody formation through stabilization of Tcf7 transcripts.

Yingpeng Yao
Ying Yang
Shuyang Yu
ResearchOpen Access26 Feb 2021
Nature Communications

Volume: 12, P: 1-16
Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors

Detect-seq, built upon chemical labeling and enrichment of intermediate deoxyuridine, offers an approach to profile different types of off-target mutation induced by cytosine base editors including unexpected edits outside of protospacer and on the target strand.

Zhixin Lei
Haowei Meng
Chengqi Yi
Research07 Jun 2021
Nature Methods

Volume: 18, P: 643-651
Draining of an ancient lake in the Hexi Corridor 4500 years ago triggered migration of the Hei Shan civilization

An ancient lake in the Hexi Corridor, which was to become part of the Silk Road, was an important occupation site of the Hei Shan civilization for 5000 years, but its later drainage, 4500 years ago, triggered human migration from this site. This is shown by thermoluminescence dating and facies analysis of sedimentary rocks from the northeastern margin of the Tibetan Plateau, correlated with interpretations of Hei Shan rock paintings.

Zijuan Dong
Zhenbo Hu
Renzhe Pan
ResearchOpen Access23 May 2025
Communications Earth & Environment

Volume: 6, P: 1-9
A simple and rapid diagnostic method for 13 types of high-risk human papillomavirus (HR-HPV) detection using CRISPR-Cas12a technology

Jiaojiao Gong
Guanghui Zhang
Guanghui Tang
ResearchOpen Access17 Jun 2021
Scientific Reports

Volume: 11, P: 1-8
Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity

Huang et al. show that, in response to chemotherapy, PTEN directly interacts with NLRP3 in myeloid cells to enhance inflammasome activation and antitumour immune responses.

Yi Huang
Huanyu Wang
Rongbin Zhou
Research04 May 2020
Nature Cell Biology

Volume: 22, P: 716-727
Myeloid PTEN loss affects the therapeutic response by promoting stress granule assembly and impairing phagocytosis by macrophages in breast cancer

Yan Li
Chao Xu
Yueyin Pan
ResearchOpen Access30 Jul 2024
Cell Death Discovery

Volume: 10, P: 1-14
Study on stability evaluation of goaf based on AHP and EWM—taking the northern new district of Liaoyuan city as an example

Yichen Zhang
Zhou Wen
Menghao Li
ResearchOpen Access02 Aug 2024
Scientific Reports

Volume: 14, P: 1-19
Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale

Chemical modification of 5fC allows its enrichment and genome-wide profiling at single-nucleotide resolution.

Bo Xia
Dali Han
Chengqi Yi
Research07 Sept 2015
Nature Methods

Volume: 12, P: 1047-1050
2,3-Butanediol synthesis from glucose supplies NADH for elimination of toxic acetate produced during overflow metabolism

Wensi Meng
Lijie Zhang
Chao Gao
ResearchOpen Access08 Jun 2021
Cell Discovery

Volume: 7, P: 1-12
Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages

Yuxin Shu
Nanfei Yang
Pingping Shen
ResearchOpen Access02 Feb 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-3
Effects of atomic-level nano-structured hydroxyapatite on adsorption of bone morphogenetic protein-7 and its derived peptide by computer simulation

Qun Wang
Menghao Wang
Guoming Lu
ResearchOpen Access09 Nov 2017
Scientific Reports

Volume: 7, P: 1-14
Methanol-Independent Protein Expression by AOX1 Promoter with trans-Acting Elements Engineering and Glucose-Glycerol-Shift Induction in Pichia pastoris

Jinjia Wang
Xiaolong Wang
Menghao Cai
ResearchOpen Access02 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
Heterologous pathway assembly reveals molecular steps of fungal terreic acid biosynthesis

Chuixing Kong
Hezhou Huang
Menghao Cai
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-12
Genome-Wide Determination of Gene Essentiality by Transposon Insertion Sequencing in Yeast Pichia pastoris

Jinxiang Zhu
Ruiqing Gong
Mian Zhou
ResearchOpen Access05 Jul 2018
Scientific Reports

Volume: 8, P: 1-13

Search

Integrating trade-offs and supply-demand into ecosystem service zoning management to provide more targeted management strategies from the water-food-ecosystem nexus perspective

Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet’s disease

Author Correction: TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease

TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease

A family of dual-anion-based sodium superionic conductors for all-solid-state sodium-ion batteries

DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes

Author Correction: Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models

Bevel-edge epitaxy of ferroelectric rhombohedral boron nitride single crystal

Stabilization of layered lithium-rich manganese oxide for anion exchange membrane fuel cells and water electrolysers

Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models

Malleable, printable, bondable, and highly conductive MXene/liquid metal plasticine with improved wettability

Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA

METTL3-dependent m⁶A modification programs T follicular helper cell differentiation

Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors

Draining of an ancient lake in the Hexi Corridor 4500 years ago triggered migration of the Hei Shan civilization

A simple and rapid diagnostic method for 13 types of high-risk human papillomavirus (HR-HPV) detection using CRISPR-Cas12a technology

Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity

Myeloid PTEN loss affects the therapeutic response by promoting stress granule assembly and impairing phagocytosis by macrophages in breast cancer

Study on stability evaluation of goaf based on AHP and EWM—taking the northern new district of Liaoyuan city as an example

Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale

2,3-Butanediol synthesis from glucose supplies NADH for elimination of toxic acetate produced during overflow metabolism

Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages

Effects of atomic-level nano-structured hydroxyapatite on adsorption of bone morphogenetic protein-7 and its derived peptide by computer simulation

Methanol-Independent Protein Expression by AOX1 Promoter with trans-Acting Elements Engineering and Glucose-Glycerol-Shift Induction in Pichia pastoris

Heterologous pathway assembly reveals molecular steps of fungal terreic acid biosynthesis

Genome-Wide Determination of Gene Essentiality by Transposon Insertion Sequencing in Yeast Pichia pastoris

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