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Aging is associated with a loss of blood stem cell fitness in part due to defects in stem cell-supportive niches. Here, the authors demonstrate that restoring niche function by treatment with Netrin-1 is able to rejuvenate aged blood stem cells.

In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.

Drug combinations consisting of two cell death-targeting drugs are enriched for antagonism and ‘single-agent dominance’, where the faster-acting drug suppresses the slower-acting drug due to inhibitory crosstalk between cell death pathways.

Evidence for a past large explosive eruption within the Santorini caldera suggests that early stages of silicic caldera cycles can be more hazardous than previously assumed, according to analyses of intra-caldera deposits from the Kameni Volcano.

CLOCK (CLK) is essential for the development and maintenance of circadian rhythms in Drosophila. Here, the authors show that Clk mRNA is regulated by miRNA bantam, and deletion of bantambinding site leads to stochastic CLK-driven transcription and development of the circadian neurons.

Papsdorf et al. show that mono-unsaturated fatty acids extend lifespan of C. elegans through induction of peroxisomes and lipid droplets in fat tissues and of a lipid signature predictive of decreased lipid oxidation.

Dynamic interface printing is a new form of 3D printing that leverages an acoustically modulated, constrained air–liquid boundary to rapidly generate centimetre-scale 3D structures within tens of seconds.

The transmission spectrum of the exoplanet WASP-39b is obtained using observations from the Single-Object Slitless Spectroscopy mode of the Near Infrared Imager and Slitless Spectrograph instrument aboard the JWST.

A vascular cell atlas integrating single-cell data of 19 organs and tissues from 62 donors identifies angiotypic and organotypic characteristics of endothelial and mural cells.

Self-limited assembly of 'imperfect' chiral nanoparticles enables formation of bowtie-shaped microparticles with size monodispersity and continuously variable chirality to be used for printing photonically active metasurfaces.

Dragwidge et al. report that the plant endocytic complex, the TSET–TPLATE complex, undergoes biomolecular condensation through interactions with plasma membrane phospholipids and recruits clathrin for endocytosis.

Here the authors demonstrate that Xenon plasma can shape thick frozen-hydrated biological samples for structure determination of molecules in the cellular context and demonstrating the potential of the technique to be used on more complex samples.

Sixt and colleagues show that, in environments where even the largest pores preclude free passage, leukocytes position their nucleus behind the centrosome and assemble a central F-actin pool that pushes outward to transiently dilate a path for the nucleus.

Polyethylene terephthalate (PET) tape is widely used for lithium-ion batteries but its chemical stability has been largely overlooked. Reversible self-discharge is now shown to be virtually eliminated in LiFePO₄–graphite cells by replacing PET with polypropylene jellyroll tape.

Surface potential measurements of parallel WSe₂ and MoS₂ multi-layers with aligned and anti-aligned configurations of the polar interfaces were conducted showing evenly spaced, nearly decoupled potential steps, indicative of highly confined interfacial electric fields.

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic lateral sclerosis-associated FUS and TDP-43 mutants.

The ability to map the activity of synapses within a circuit will help in elucidating the neural basis of behaviour. Here, Macpherson et al. report new strategies to specifically label active synapses in Drosophila with multi-colour fluorescence tags.

Integrating cell-laden hydrogels effectively into the 3D printing process is a challenge in the creation of tissue engineering scaffolds. Here, the authors describe an additive manufacturing technique to combine polymer and cell-containing networks with 3D-printed mechanical supports.

To improve the efficiency of photovoltaic devices while keeping the same spatial footprint, solar cells can be stacked on top of each other. Here, Essig et al. fabricate very efficient dual-junction and triple-junction solar cells by placing one or two III–V solar cells on top of a silicon solar cell.

Whole-genome sequences and field experiments focusing on the global invasive forage crop, Trifolium repens, show high levels of genetic variation across continents and parallel signatures of selection in five haploblocks.

FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

The Nikon A1R HD25 confocal system with NIS-Elements AI software enables rapid, deep, quantitative imaging of living organs-on-chips.

Complex clinical samples can be imaged with 25 nm resolution using a light-emitting-diode-based wide-field microscope.

Wenzel et al. detect radio signatures of two forms of cyanopyrene, a small molecular sheet of carbon, which can be used as indicators of the abundance of pyrene. Their findings suggest that small polycyclic aromatic hydrocarbons must be formed in or transported to the cold interstellar medium.

Skyrmions in synthetic antiferromagnets are appealing for use in future memory and computing devices, combining small size and fast motion, but creating, stabilizing, and observing them remains a challenge. Here, Juge et al demonstrate the stabilization and current and light induced nucleation of skyrmions in a synthetic antiferromagnet, observing the magnetization texture in each layer using X-ray magnetic microscopy.

Redox signal transduction from the mitochondrial matrix to the cytosol is shown to be mediated through interaction between MIC60 and Miro, the disruption of which ameliorates oxidative stress in Drosophila.

While the impact of F-actin architecture on stress transmission is well studied, the role of architecture on stress generation remains unclear. Here authors use in vitro model and show that distinct organizations constrain myosin motion.

In this work, the authors report how the termination factor Sen1 interacts with an elongating RNA polymerase II (Pol II) and its nascent transcript to perform termination. Comparison of two pretermination states of Pol II supports a hypertranslocation model of termination.

High-performance engineered myosins robustly change speed or direction in response to an optical signal. In living cells, these motors localize to the tips of protrusions when illuminated and deliver molecular cargos.

The authors show an original approach to achieve strong light-matter interaction harnessing the coupling between plasmonic resonators and the Landau resonances of an underlying quantum well, demonstrating remarkably high coupling strengths.

Scheibner et al. demonstrate that, during gastrulation in the mouse, epithelial epiblast progenitors upregulate Foxa2 and form the definitive endoderm independently of a full EMT–MET cycle.

Confining atoms to lattices can modify their interaction and collision. Here the authors show suppression of dipolar relaxation in the form of reduced decay rate of dysprosium atoms in quasi-2D regime.

The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cytotoxicity, signal inhibition, antibody dependent cellular cytotoxicity and phagocytosis.

Extracting lithium from alternative aqueous sources becomes crucial in meeting increasing lithium demand. Here, authors design an economically feasible electrochemical process that achieves selective lithium extraction from geothermal brine and finally produce battery grade lithium hydroxide.

A CMOS-compatible watt-class power amplifier based on large-mode waveguide technology is realized with an on-chip output power reaching ~1 W within a footprint of ~4 mm², enabling integrated photonics to tackle true systems level integration.

Stress transitions from horizontally forced compression to vertically forced extension during subduction initiation, according to seismic images of the Puysegur plate boundary, New Zealand.

The authors report the measurement of the Little-Parks effect in the unconventional superconductor candidate 4Hb-TaS₂. They find a π-shift in the transition-temperature oscillations and an ehancement of T_c as a function of the out-of-plane field when a constant in-plane field is applied, consistent with a multi-component order parameter.

The behaviour of a superconductor can be altered by changing its symmetry properties. Coherently coupling two Josephson junctions breaks time-reversal and inversion symmetries, giving rise to a device with a controllable superconducting diode effect.

In this work, the authors probe the efficacy of BWC0977, a bacterial topoisomerase inhibitor, in pre-clinical animal models, also demonstrating that BWC0977 is safe and well tolerated in healthy human volunteers, in a phase 1 trial.

Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocyte membrane and undergoes continuous remodeling throughout invasion.

By combining a CMOS-based integrated circuit with flexible and collapsible radiating structures, a scalable phased array architecture can be fabricated that has an areal mass density of only 0.1 g cm⁻².

Suppressing surface Cs⁺ accumulation in methylammonium-free α-FA_1−xCs_xPbI₃ perovskite with an intermediate phase-assisted strategy enables high-efficiency and thermally stable photovoltaics.

Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.

Liquid crystalline elastomers (LCE) exhibit shape transformation when subjected to various stimuli, but the achievable thickness of LCE films is limited. Here the authors demonstrate arbitrarily thick LCE films that are continuous in composition and maintain the director orientation, prescribed into the material.

The actin-based motor Myosin1d is needed to establish left–right asymmetry in Drosophila. Here the authors show that myosin 1d has a role in lumen formation, vacuole trafficking and left-right asymmetry establishment during zebrafish development.

We propose high-performance, tunable twisted bilayers for beam steering. An analytical model reveals their operation principles, enabling the design of simplified, efficient device candidates.