By conducting a large multi-ancestry GWAS of varicose veins followed by bioinformatics analyses, Levin et al. identified new and recurrent causal variants, traits with shared genetic mechanisms, and putative causal risk factors of the disease, revealing its polygenic architecture and genetic overlap with arterial and venous disease and identifying potential therapeutic targets.
- Michael G. Levin
- Jennifer E. Huffman
- Scott M. Damrauer