Nature Search

Water quality management could halve future water scarcity cost-effectively in the Pearl River Basin

Future water scarcity is expected to increase up to fourfold in most parts of the Pearl Basin by 2050, driven by changes in both water quantity and quality. Water quality management options could cost-effectively half future water scarcity.

Safa Baccour
Gerwin Goelema
Maryna Strokal
ResearchOpen Access06 Jul 2024
Nature Communications

Volume: 15, P: 1-13
GP participation in increasing uptake in a national bowel cancer screening programme: the PEARL project

Sally C Benton
Piers Butler
Stephen W Duffy
ResearchOpen Access18 May 2017
British Journal of Cancer

Volume: 116, P: 1551-1557
More urbanization, more polarization: evidence from two decades of urban expansion in China

Yi’na Hu
Dylan Shane Connor
B. L. Turner II
ResearchOpen Access11 Jul 2024
npj Urban Sustainability

Volume: 4, P: 1-11
Mixed responses of tropical Pacific fisheries and aquaculture to climate change

Climate change has the potential to disrupt marine habitats and food webs. Targeted multidisciplinary research reveals how this is likely to affect the contributions of fisheries and aquaculture to the food security and economies of Pacific islands.

Johann D. Bell
Alexandre Ganachaud
Michelle Waycott
Research10 Mar 2013
Nature Climate Change

Volume: 3, P: 591-599
Spiral nematodes, soil microbiome and micronutrients increase chickpea drought susceptibility but do not induce symptoms of the emerging health issue

Victoria A. Marchesini
Jennifer Town
Michelle Hubbard
ResearchOpen Access13 Nov 2025
Scientific Reports

Volume: 15, P: 1-13
Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR

Robert E. Oswald
Michael J. Bogusky
Christopher M. Dobson
Research09 Feb 1989
Nature

Volume: 337, P: 579-582
Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle

It is becoming clear that heterogeneity in cancer cell cycles corresponds to variability of response to therapies targeting cyclin dependent kinases (CDKs). Here, the authors investigate CDK2-dependancy and response to CDK2 inhibition across different cancers, identifying markers of sensitivity and combinatorial therapeutic strategies.

Vishnu Kumarasamy
Jianxin Wang
Erik S. Knudsen
ResearchOpen Access09 Feb 2025
Nature Communications

Volume: 16, P: 1-21
Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

Deborah Defeo-Jones
Pearl S. Huang
Alien Oliff
Research18 Jul 1991
Nature

Volume: 352, P: 251-254
Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer

An inherently explainable AI trained on 1,015 expert-annotated prostate tissue images achieved strong Gleason pattern segmentation while providing interpretable outputs and addressing interobserver variability in pathology.

Gesa Mittmann
Sara Laiouar-Pedari
Titus J. Brinker
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Characterizing trachoma elimination using serology

The study advances the use of serological surveys to guide trachoma elimination program decisions and provides a way to set thresholds for whether or not to continue an intervention program.

Everlyn Kamau
Pearl Anne Ante-Testard
Benjamin F. Arnold
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Author Correction: Targeting glutamine metabolism slows soft tissue sarcoma growth

Pearl Lee
Dania Malik
M. Celeste Simon
Amendments and CorrectionsOpen Access30 Aug 2024
Nature Communications

Volume: 15, P: 1
SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8⁺ T-cells

Here, the authors show in a cohort of people with HIV, COVID mRNA vaccination is followed by a transient boost in a particular profile of HIV-specific T-cell responses and a corresponding decrease in residual HIV RNA – suggesting productive immune engagement with infected cells.

Eva M. Stevenson
Sandra Terry
R. Brad Jones
ResearchOpen Access19 Aug 2022
Nature Communications

Volume: 13, P: 1-15
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Quality matters for water scarcity

Quality requirements for water differ by intended use. Sustainable management of water resources for different uses will not only need to account for demand in water quantity, but also for water temperature and salinity, nutrient levels and other pollutants.

Michelle T.H. van Vliet
Martina Flörke
Yoshihide Wada
Comments & Opinion09 Oct 2017
Nature Geoscience

Volume: 10, P: 800-802
Cell types of origin of the cell-free transcriptome

Cell types affected by various diseases are inferred from cell-free RNA.

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
ResearchOpen Access07 Feb 2022
Nature Biotechnology

Volume: 40, P: 855-861
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

The 3CL protease of SARS-CoV-2 is inhibited by PF-00835231 in vitro. Here, the authors show that the prodrug PF-07304814 has broad spectrum activity, inhibiting SARS-CoV and SARS-CoV-2 in mice and its ADME and safety profile support clinical development.

Britton Boras
Rhys M. Jones
Charlotte Allerton
ResearchOpen Access18 Oct 2021
Nature Communications

Volume: 12, P: 1-17
Targeting glutamine metabolism slows soft tissue sarcoma growth

Glutamine is an energetic source required for the proliferation of cancer cells. Here, the authors show that soft tissue sarcomas expressing high levels of glutaminase (GLS) are particularly sensitive to glutamine starvation and GLS inhibition in tumour-bearing allograft and autochthonous mouse models.

Pearl Lee
Dania Malik
M. Celeste Simon
ResearchOpen Access24 Jan 2020
Nature Communications

Volume: 11, P: 1-15
Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques

An adjuvanted SARS-CoV-2 spike-ferritin nanoparticle vaccine can elicit antibodies with relatively broad sarbecovirus activity in non-human primates. Here, the authors isolate and structurally characterize several monoclonal antibodies providing insights into the targeted epitopes and broad reactivity.

Rajeshwer S. Sankhala
Kerri G. Lal
M. Gordon Joyce
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-19
ALFQ adjuvanted HIV-1 envelope protein vaccination elicits durable functional antibody and cellular responses in nonhuman primates

Shikha Shrivastava
Joshua M. Carmen
Mangala Rao
ResearchOpen Access19 Dec 2025
npj Vaccines

Volume: 11, P: 1-21
Evaluating efficiency and accuracy of deep-learning-based approaches on study selection for psychiatry systematic reviews

In this Article, Singh and coauthors put forth a new machine-learning approach to evaluate inclusion and exclusion criteria from psychiatry abstracts to automate systematic reviews.

Aaron J. Gorelik
Mark G. Gorelik
Manpreet K. Singh
Research31 Aug 2023
Nature Mental Health

Volume: 1, P: 623-632
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

Zinc finger protein transcription factors are developed for the selective silencing of the mutant huntingtin gene in human neurons in vitro and multiple animal models of Huntington’s disease in vivo while preserving expression of the wild-type allele.

Bryan Zeitler
Steven Froelich
H Steve Zhang
Research01 Jul 2019
Nature Medicine

Volume: 25, P: 1131-1142
FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome

Li et al. show that hepatocyte-specific loss of Fbp1 in mice leads to steatosis and senescence in hepatic stellate cells, thereby disrupting metabolism and facilitating liver tumorigenesis.

Fuming Li
Peiwei Huangyang
M. Celeste Simon
Research04 May 2020
Nature Cell Biology

Volume: 22, P: 728-739
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression

Alessandro Tancredi
Olga Gusyatiner
Monika E. Hegi
ResearchOpen Access13 Dec 2022
Cell Death & Disease

Volume: 13, P: 1-12
Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma

MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight the role of the RNA-binding protein, Musashi-1 (MSI1) in G3 MB and identify MSI1-bound targets sharing MYC associated pathways.

Michelle M. Kameda-Smith
Helen Zhu
Sheila K. Singh
ResearchOpen Access06 Dec 2022
Nature Communications

Volume: 13, P: 1-19
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

Markov, Ren, Senkow and colleagues report that in patients with severe SARS-CoV-2 pneumonia, alveolar T cell interferon responses targeting structural SARS-CoV-2 proteins characterized patients who recovered, whereas responses against nonstructural proteins and activation of NF-κB were associated with poor outcomes.

Nikolay S. Markov
Ziyou Ren
Brian White
Research13 Aug 2024
Nature Immunology

Volume: 25, P: 1607-1622
Molecular imaging of a fluorescent antibody against epidermal growth factor receptor detects high-grade glioma

Quan Zhou
Johana C. M. Vega Leonel
Gerald A. Grant
ResearchOpen Access11 Mar 2021
Scientific Reports

Volume: 11, P: 1-12
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?

CHK2, an important player in the DNA-damage response signalling pathway, is a candidate multiorgan tumour susceptibility gene. Will the targeted modulation of this kinase or exploitation of its loss in tumours prove to be an effective anti-cancer strategy?

Laurent Antoni
Nayanta Sodha
Michelle D. Garrett
Reviews01 Dec 2007
Nature Reviews Cancer

Volume: 7, P: 925-936
Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Analysis of bronchoalveolar lavage fluid samples from patients with SARS-CoV-2-induced respiratory failure suggests that SARS-CoV-2 infects alveolar macrophages to cause release of T cell chemoattractants, thereby inducing local inflammatory cytokine release and further T cell activation, ultimately resulting in a positive feedback loop that drives alveolar inflammation.

Rogan A. Grant
Luisa Morales-Nebreda
Ziyou Ren
Research11 Jan 2021
Nature

Volume: 590, P: 635-641
Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

Ma, Hernandez et al develop a 3D culture-transplant system to enable studies of cancer metastasis using patient-derived xenograft (PDX) tumor cells. Using this system, they find that OXPHOS inhibition attenuates the lung metastatic capacity of breast cancer cells and that overexpression of the metabolic enzyme NME1 increases lung metastasis.

Dennis Ma
Grace A. Hernandez
Devon A. Lawson
ResearchOpen Access05 Nov 2021
Communications Biology

Volume: 4, P: 1-15
Diagnosis of spinal epidural abscess: a case report and literature review

Chidinma Chima-Melton
Michelle Pearl
Marni Scheiner
Research06 Apr 2017
Spinal Cord Series and Cases

Volume: 3, P: 1-4
Comprehensive genetic analysis of the cystic fibrosis transmembrane conductance regulator from dried blood specimens – Implications for newborn screening

Anja Kammesheidt
Martin Kharrazi
Steven Keiles
Research01 Sept 2006
Genetics in Medicine

Volume: 8, P: 557-562
Cystic fibrosis newborn screening programs: implications of the CFTR variant spectrum in nonwhite patients

Lynn Pique
Steve Graham
Iris Schrijver
Research05 May 2016
Genetics in Medicine

Volume: 19, P: 36-44
Calibration of a serum reference standard for Group B streptococcal polysaccharide conjugate vaccine development using surface plasmon resonance

Alexandre Esadze
Christopher D. Grube
Raphael Simon
ResearchOpen Access19 May 2023
npj Vaccines

Volume: 8, P: 1-10
Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) clinical trial

Scott Stanslaski
Rebekah L. S. Summers
Helen Bronte-Stewart
ResearchOpen Access17 Sept 2024
npj Parkinson's Disease

Volume: 10, P: 1-11
Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics

Lucas Rodrigues
Joshua Watson
Shaying Zhao
ResearchOpen Access06 Jul 2023
Scientific Reports

Volume: 13, P: 1-12

Search

Water quality management could halve future water scarcity cost-effectively in the Pearl River Basin

GP participation in increasing uptake in a national bowel cancer screening programme: the PEARL project

More urbanization, more polarization: evidence from two decades of urban expansion in China

Mixed responses of tropical Pacific fisheries and aquaculture to climate change

Spiral nematodes, soil microbiome and micronutrients increase chickpea drought susceptibility but do not induce symptoms of the emerging health issue

Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR

Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer

Characterizing trachoma elimination using serology

Author Correction: Targeting glutamine metabolism slows soft tissue sarcoma growth

SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8⁺ T-cells

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Quality matters for water scarcity

Cell types of origin of the cell-free transcriptome

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Targeting glutamine metabolism slows soft tissue sarcoma growth

Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques

ALFQ adjuvanted HIV-1 envelope protein vaccination elicits durable functional antibody and cellular responses in nonhuman primates

Evaluating efficiency and accuracy of deep-learning-based approaches on study selection for psychiatry systematic reviews

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression

Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma

Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

Molecular imaging of a fluorescent antibody against epidermal growth factor receptor detects high-grade glioma

CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

Diagnosis of spinal epidural abscess: a case report and literature review

Comprehensive genetic analysis of the cystic fibrosis transmembrane conductance regulator from dried blood specimens – Implications for newborn screening

Cystic fibrosis newborn screening programs: implications of the CFTR variant spectrum in nonwhite patients

Calibration of a serum reference standard for Group B streptococcal polysaccharide conjugate vaccine development using surface plasmon resonance

Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) clinical trial

Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics

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