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The build-up of iron in the body can have serious consequences; current treatment therapies suffer from adverse side effects and toxicity. Here, the authors developed renal clearable nanochelators with improved pharmacodynamics and demonstrated their efficacy and safety in iron overload animal models.

A wearable epidermal sweat sensing platform that contains a printed low-power electrochromic display and a stretchable Ag₂O–Zn battery can collect, analyse and present electrochemical data in real time without the need to connect to external devices.

Quorum sensing is a regulatory mechanism controlling bacterial signaling and ComA, a conserved efflux pump, is responsible for the maturation and secretion of peptide signals. Here, authors determine the 3D structure and demonstrate its function as an ABC transporter.

Here, the authors observed significant genetic correlation of GlycA with lung function, asthma and COPD and identified ten shared loci revealing potential shared biological mechanisms involving ubiquitination and Wnt/β-catenin signaling.

Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp³)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.

Realistic tumour models are critical for the development of clinically relevant treatments. Here, the authors develop a lung cancer assembloid model which recapitulates key components of the primary tumour, and can be used to predict clinical outcome.

Leveraging a label-free interferometric scattering microscope, scientists tracked numerous cargos within a crowded cellular environment. Intriguingly, cells employ effective strategies echoing human transportation systems to manage such transportation hurdles.

Single-crystalline materials can be grown on amorphous surfaces at below 400 °C, enabling monolithic three-dimensional integration of vertically stacked transistors.

Improved understanding of passivation leads to near-infrared perovskite light-emitting diodes with 21.6% external quantum efficiency.

Mammalian eggs require a single sperm for viable fertilization, and cortical granule exocytosis prevents additional sperm binding. Vogt et al. image at single granule resolution to document that cortical granule anchoring in the cortex ensures proper trafficking, exocytosis and polyspermy block.

Flexoelectricity exists in every dielectric material exposed to a strain gradient and is enhanced at the nanoscale. However, precisely determining flexoelectric coupling parameters at the nanoscale is challenging, but has been overcome here by measuring the current across a tunnel junction.

Tin perovskites have emerged as promising alternatives to toxic lead perovskite in next-generation photovoltaics, but the poor environmental stability remains an obstacle for the application. Here, the authors study the degradation mechanism of tin perovskite films, and identify a cyclic degradation mechanism involving tin (IV) iodide.

The development of giant oligomeric donors to replace batch-varied polymer remains challenging. Here, the authors regulate the assembly behaviour of giant dimeric donors, realizing all-giant-oligomeric-based organic solar cells with promising device efficiency and stability.

Antibiotic resistance is a major issue in medicine and new antimicrobials for treating resistant infection are needed. Here, the authors report on antibacterial peptoid polymers, prepared via NNCA ring-opening polymerization, demonstrating antibacterial function against MRSA in vitro and in in vivo infection models.

Designing and manufacturing eco/bioresorbable electronic systems remains a challenge. The authors introduce a picosecond-pulsed laser-based scheme that exploits controlled patterning, thinning, and/or cutting to manipulate multilayers of eco/bioresorbable materials for a wide range of advanced electronic systems.

Disposable filters are generally used for air purification despite frequent replacement and waste generation problems. Here, a ceramic catalyst filter is introduced as a new class of filter that simultaneously removes PMs and VOCs as primary air pollutants and can be regenerated and used for long periods by simple water washing.

Data from two large longitudinal cohorts in China, in which the participants were clustered into five groups based on their metabolic characteristics, show that a signature of microbiome age modulates the risk of cardiovascular disease in metabolically unhealthy individuals.

The report for the multi-carbon homologation of alkynes with CO₂ to construct important non-conjugated alkynyl-containing acids is rare. Herein, the authors report alkynylcarboxylation of alkenes with CO₂ via photoredox and copper dual catalysis, affording non-conjugated alkynyl acids from readily available alkynes, alkenes and CO₂.

The large-scale synthesis of high-concentration dispersions of 2D nanosheets remains challenging. Here, the authors report a multi-step process to produce aqueous dispersions of few-layer graphene with ~94.5 wt.% yield and concentrations exceeding 100 mg/mL, showing the important role of inter-sheet repulsive excluded volume interactions.

Ni-rich cathodes in all-solid-state batteries experience capacity fading due to surface degradation, particle isolation and detachment at the cathode–electrolyte interface. This study quantifies these degradation factors, showing that detachment increases with Ni content and emphasizing the need for strategies to address these challenges.

The best base editor for specific applications is predicted with a deep learning model.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Chitin oligomers from fungal cell walls induce plant immunity. Genetic evidence shows that chitin deacetylation by a secreted fungal enzyme hides the presence of the pathogen from the immune recognition system and is essential for host colonization.

Single-particle electron microscopy and hydrogen–deuterium exchange mass spectrometry are used to characterize the structure and dynamics of a G-protein-coupled receptor–arrestin complex.

Improving the manufacturability of perovskite solar cells is key to their deployment. Zheng et al. report a one-step deposition of the hole-selective and absorber layers that addresses wettability issues and simplifies the fabrication process.

Triply degenerate point (TP) fermions have been reported in MoP but the TPs are far below the Fermi level. Here, Guo et al. predict and verify the possible existence of TP fermions in trigonal layered PtBi₂, where the TP points are close to the Fermi level.

The authors prepare an all-organic dielectric film with a nano-submicron surface layer via electrospinning technology, achieving a simultaneous improvement in the discharged energy density and charge/discharge efficiency.

Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy. Here the authors perform stage-wise chemical screening to develop an improved protocol for hPSC differentiation to functional pancreatic beta cells at high efficiency.

This paper proposes a dual-pinning mechanism induced by a magneto-electric bias interface and uses it to designs a double-layer core-shell structure, demonstrating that the mechanism improves electromagnetic wave absorption in the low-frequency bands.

Development of a dual-mode device for driving humanoid robot.

Many genetic loci have been identified to be associated with kidney disease, but the molecular mechanisms are not well understood. Here, the authors perform epigenome-wide association studies on kidney function measures to identify epigenetic marks and pathways involved in kidney function.

Molecular design of acceptor and donor molecules has enabled major progress in organic photovoltaics. Li et al. show that branched alkyl chains in non-fullerene acceptors allow favourable morphology in the active layer, enabling a certified device efficiency of 17.9%.

Unlike diffusion-mediated chemical short-range orders (SROs) in multi-principal element alloys, diffusionless SROs and their impact on alloys have been elusive. Here, the authors show the formation of strain-induced SROs by crystalline lattice defects, upon external loading at 77 K.

By characterizing the dynamics of epitranscriptomes and translatomes upon Magnaporthe oryzae infection, the authors uncover that ac4C enriched in the 3rd nt of codons improves translation of mRNA to enhance rice resistance against M. oryzae.

In semiconductors, an absorbed photon can generate multiple electron-hole pairs, but measurements of this carrier multiplication efficiency in nanocrystals need to correctly account for charged excitons. Xiaoet al.meet this need by measuring energy transfer of biexcitons from nanocrystals to acceptor dyes.

The nonlinear Hall effect (NLHE) results in a second-harmonic transverse voltage in response to alternating longitudinal current in zero magnetic field and has so far only been observed at low temperatures in bulk materials. Here, the authors observe bulk NLHE at room temperature in the Dirac material BaMnSb₂, which will provide a large photocurrent for applications in THz detection.

Metamaterial memory devices often require a large stimulus to switch states or suffer from poor thermal stability. Here, the authors fabricate a terahertz metadevice driven by ferroelectric and graphene layers, and obtain multiple level memory devices stable at room temperature.

Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice.

In standard SERS the probability for the molecules to reach tiny hotpot regions is low. Here, the authors introduce an approach based on warped spaces that offers a strategy to manipulate hotspots of metallic nanostructures, resulting in large broadband enhancements in both the magnitude and the volume size.

It is crucial to design ZnO with uniform nanoscale features to reduce thermal conductivity while maintaining electrical conduction pathways. Authors realize a high figure-of-merit value of 0.486 at 580 K by interfacing graphene quantum dots with three-dimensional nanostructured ZnO.

Retaining high performance of perovskite solar cells over large areas is a challenge. Yang et al. use a thermotropic liquid crystal with high diffusivity that does not co-crystallize with the perovskite, suppressing defect formation and enabling large-area solar modules with improved stability and efficiency.

A built-in electric field at the interface of metals and centrosymmetric semiconductors is shown to induce polar structures in the semiconductors and generate substantial piezoelectric and pyroelectric effects.

An atomically coherent interlayer between the electron-transporting and perovskite layers in perovskite solar cells enhances charge extraction and transport from the perovskite, enabling high power conversion efficiency.

FeCo@N—C nanoparticle as a bi-functional catalyst in both oxygen reduction reaction and hydrogen evolution reaction.

The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.