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Direct recycling of critical battery materials bring promise but a challenge for the mixed cathode chemistries. Here, the authors report a sustainable upcycling approach, transforming degraded LiFePO₄ and Mn-rich cathodes into a high-voltage polyanionic material with an increased energy density and economic value.

Fuel cells rely on costly and scarce platinum-group metals to catalyse both anodic and cathodic reactions. Here a catalyst consisting of atomically dispersed iridium and phosphorus on carbon is presented, where adjacent iridium and phosphorus sites work as integrative catalytic pairs to synergically boost the performance for the hydrogen oxidation reaction.

Cryo-EM structures of sulfated cholecystokinin 8 bound to the cholecystokinin A receptor in complex with G_s, G_i and G_q heterotrimers reveal structural determinants for G-protein coupling selectivity.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Researchers demonstrate the high-coherence parallelization in integrated photonics. Their high-coherence, high-power, multiwavelength light source drives a silicon photonic link with a 60 Tbit/s data rate and significantly reduces digital signal processing consumption.

Cryo-electron microscopy structures of mouse trace amine-associated receptor 9 reveals structural motifs involved in odorant ligand recognition, including a unique disulfide bond linking the N terminus to extracellular loop 2.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knockout mice and show lack antiviral action in human lung cells and human lung organoids, likely due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells.

 A transcriptomic cell-type atlas of the whole adult mouse brain with ~5,300 clusters built from single-cell and spatial transcriptomic datasets with more than eight million cells reveals remarkable cell type diversity across the brain and unique cell type characteristics of different brain regions. 

Understanding the utility of SARS -CoV-2 vaccination platforms and strategies through the emerging pandemic and beyond are critical to understanding the efficacy of such interventions. Here the authors assess nasal delivery of an influenza virus based viral vector for vaccination against SARS-CoV-2 in a hamsters model and assess the induced immunity.

A large light-receiving angle in planar solar cells is crucial for flexible installation of distributed photovoltaics. Here, authors report sequential-processed all-polymer solar cells with nano-sized phase separation integrated in micro-sized surface topology and maximum efficiency of over 19%.

The genome sequences of 175 Ebola virus from five districts in Sierra Leone, collected during September–November 2014, show that the rate of virus evolution seems to be similar to that observed during previous outbreaks and that the genetic diversity of the virus has increased substantially, with the emergence of several novel lineages.

Vascular smooth muscle cells (VSMCs) are known for their fate plasticity in atherosclerosis plaque progression. Here, Zhai et al. show that extracellular traps generated from CD68 ⁺ VSMCs adversely contribute to plaque progression and highlight their unexpected role in plaque stability by regulating the direction of VSMC trans-differentiation.

Hybrid rice varieties are bred using male-sterile maternal lines, which are unable to self-pollinate. Here, the authors show that mutations of the tms5 gene, which codes for RNase Z^S1, result in the accumulation of ubiquitin fusion ribosomal protein mRNAs at high temperature to confer genic male sterility.

Understanding the training dynamics of quantum neural networks is a fundamental task in quantum information science. Here, the authors show how these follow generalized Lotka-Volterra equations, revealing a transition between frozen-kernel, critical point and frozen-error dynamics. Theoretical findings, validated on IBM devices, provide insight to cost function design.

Recycling forms an essential dimension of batteries’ sustainability. Here the authors show a straightforward process that directly upgrades spent LiCoO₂ to a Mg and Al co-substituted LiCoO₂ cathode with a high voltage of 4.6 V and excellent cycling stability.

The combination of anti-PD-1 treatment with cisplatin and 5-fluorouracil in patients with previously untreated, PD-L1-positive esophageal squamous cell carcinoma improved progression-free survival and overall survival.

Riboswitches consist of an aptamer domain and expression platform, which senses a signal and regulates gene expression, respectively. Here the authors show that the expression platform of a SAM-I riboswitch from the Gram-negative bacteria can sense and bind uncharged an initiator Met tRNA to control the met operon.

The chromatin accessibility landscape and gene regulatory network of pancreatic cancer has not been fully characterised. Here, the authors perform multi-omics analysis of 84 pancreatic cancer organoid lines and reveal gene regulatory networks and distinct molecular subtypes.

Jun Wang and colleagues report whole-genome resequencing of 17 wild and 14 cultivated soybean accessions. They characterize population structure, patterns of linkage disequilibrium and selection in soybeans.

W. X. Zhao et al. study the higher-order topological insulator candidate Bi₄Br₄ by angle-resolved photoemission spectroscopy (ARPES) and ab-initio calculation. They provide strong evidence for the higher-order topological insulator phase, including a signature of the hinge states inside the (100) surface gap.

Breeding crop cultivars with better environmental adaptability could support crop yield stability to mitigate the effects of climate change. Combining transcriptional dynamics of florigen genes and statistical models, the daylength-sensing-based environment adaptation simulator can forecast the latitude adaptability of rice cultivars and has application potential in other crops.

The cancer cell-extrinsic roles of deubiquitinases are unclear. Here the authors show that deubiquitinase USP12 downregulation contributes to development of an immune-suppressive tumour microenvironment in KRAS-driven lung cancers and mechanistically this is through the insufficient deubiquitination of the NF-κB inhibitor, PPM1B.

Miscanthus is widely used as a feedstock for cellulosic biofuel production. Genome sequencing shows that M. floridulus is most distantly related to other Miscanthus species and is more genetically diverse.

Thermoelectric materials could reduce energy losses by converting waste heat from various processes into electricity. To cater to the needs of wearable devices, the authors design Bi₂Te₃-based thin films that show both excellent thermoelectric performance and long-sought flexibility.

Water oxidation is considered the bottleneck reaction for light-driven water splitting due to the sluggish kinetics and poor stability. Here, authors show metal- and heteroatom-doped carbons as effective catalysts for both electrochemical and photoelectrochemical water splitting.

Solar-to-chemical CO₂ reduction provides a means to use light’s energy for CO₂ removal and upgrading to useful products, although this photochemical conversion is challenging. Here, authors construct a Europium-containing metal-organic framework that selectively converts CO₂ to formate with light.

This Article explores the evolutionary paths of galaxies on the black-hole mass–stellar mass plane in the nearby Universe, linking the properties of star formation and black-hole accretion and providing critical constraints for active galactic nuclei feedback.

Histamine receptor H₁R has been extensively targeted in the development of antihistamines. Here, Wang et al. determine structures of H₁R alone and bound to different antihistamines, providing insights into the structure-based design of next-generation drugs.

Sustainable recycle of spent Li ion batteries is an effective strategy to alleviate environmental concerns and support resource conservation. Here, authors report the direct regeneration of LiFePO₄ cathode using multifunctional organic lithium salts, leading to high environmental and economic benefits.

Ji and colleagues identify Sirt6 as a regulator of chondrocyte senescence. Mechanistically, Sirt6 physically interacts with STAT5 and deacetylates it at K163, which reduces the IL-15/JAK3-induced STAT5 translocation from cytoplasm to nucleus.

Inhibitory receptors antagonize natural killer cell cytotoxicity. Ge and colleagues show that the scaffold protein β-arrestin 2 recruits the phosphatases SHP-1 and SHP-2 to the inhibitory receptor KIR2DL1 to enhance 'downstream' inhibitory signaling.

Designing an efficient electrocatalyst of hydrogen oxidation reaction is highly critical for anion exchange membrane fuel cells. Here the authors report implanting oxophilic metal atoms in PtRu nanowires to significantly improve the mass activity, stability, and resistance to CO-poisoning for hydrogen oxidation.

The seawater oxidation reaction faces challenges from competitive chloride oxidation reaction. Herein, the authors have utilized chlorine adsorption to modulate the single-atom Ir coordination state and promote seawater oxidation and catalyst stability.

China’s New Generation Artificial Intelligence Development Plan was launched in 2017 and lays out an ambitious strategy, which intends to make China one of the world’s premier AI innovation centre by 2030. This Perspective presents the view from a group of Chinese AI experts from academia and industry about the origins of the plan, the motivations and main focus for attention from research and industry.

Piezoelectric polymers usually have rather low piezoelectric coefficients less than 30 pC/N. Here, the authors achieve a highly piezoelectric polymer (d₃₃ = −62 pC/N) based on a poled biaxially oriented poly(vinylidene fluoride) with a pure β phase due to the mobile oriented amorphous fraction.

The insulation potency of CTCF depends on the number of binding sites in tandem and on upstream flanking sequences. Insulators form local chromatin domain boundaries and weaken enhancer–promoter contacts.

Accurate monitoring of chronic kidney disease (CKD) progression is essential for efficient disease management. Here Chen et al. identify five serum metabolites in patients with stage 1–5 CKD whose levels associate with disease progression, and find that 5-methoxytryptophan and its regulatory enzyme TPH-1 exert anti-fibrotic effects in mouse models of kidney injury.

Single-cell RNA-seq and in vivo lineage tracing identify unique luminal progenitors in the mouse prostate that can contribute to regeneration and oncogenesis. Single-cell RNA-seq analysis of human prostate identifies a similar cell population.

Single-atom catalysts maximize metal atom efficiency and exhibit properties that can be considerably different to their nanoparticle equivalent. Now a general host–guest strategy to make various single-atom catalysts on nitrogen-doped carbon has been developed; the iridium variant electrocatalyses the formic acid oxidation reaction with high mass activity and displays high tolerance to CO poisoning.