Nature Search

A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome

Hisamaru Hirai
Yukio Kobayashi
Fumimaro Takaku
Research04 Jun 1987
Nature

Volume: 327, P: 430-432
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Problematic online gaming mediates the association between attention-deficit/hyperactivity and subsequent mental health issues in adolescents

This study highlights the interplay of psychopathology, diminished inhibitory control, and addictive behaviors associated with negative consequences.

Zui C. Narita
Jordan DeVylder
Atsushi Nishida
ResearchOpen Access04 Aug 2025
Communications Psychology

Volume: 3, P: 1-10
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Foxd1 is a mediator and indicator of the cell reprogramming process

The forkhead box transcription factor Foxo1 is required for the maintenance of pluripotency in human embryonic stem cells. Here Koga et al.show that expression of another forkhead box transcription factor, Foxd1, promotes and indicates successful reprogramming of mouse embryonic fibroblasts.

Makito Koga
Mitsuhiro Matsuda
Miki Ebisuya
Research05 Feb 2014
Nature Communications

Volume: 5, P: 1-9
CRM1 is responsible for intracellular transport mediated by the nuclear export signal

Makoto Fukuda
Shiro Asano
Eisuke Nishida
Research20 Nov 1997
Nature

Volume: 390, P: 308-311
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Hair zinc levels and psychosis risk among adolescents

Koichi Tabata
Mitsuhiro Miyashita
Makoto Arai
ResearchOpen Access25 Nov 2022
Schizophrenia

Volume: 8, P: 1-6
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Synthetic lateral inhibition governs cell-type bifurcation with robust ratios

Cell-type diversity results from a series of binary cell fate decisions. Here, Matsuda et al.find that cells engineered with a Notch/Delta lateral inhibition circuit spontaneously bifurcate into Notch-active and Delta-positive subpopulations that are robust at the individual and population levels.

Mitsuhiro Matsuda
Makito Koga
Miki Ebisuya
Research05 Feb 2015
Nature Communications

Volume: 6, P: 1-12
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts

Keiichi Hirono
Yukiko Hata
Fukiko Ichida
ResearchOpen Access16 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells

Zhuo Wang
Satoru Kyo
Masaki Inoue
Research21 May 2002
Oncogene

Volume: 21, P: 3517-3524
Polarization-sensitive optical coherence tomography for estimating relative melanin content of autologous induced stem-cell derived retinal pigment epithelium

Mitsuhiro Matsuzaki
Michiko Mandai
Yasuo Kurimoto
ResearchOpen Access06 May 2020
Scientific Reports

Volume: 10, P: 1-11
Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents

Kazuhiro Suzuki
Syudo Yamasaki
Makoto Arai
ResearchOpen Access27 Apr 2022
Schizophrenia

Volume: 8, P: 1-6
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

Hirotomo Saitsu, Noboru Mizushima, Naomichi Matsumoto and colleagues report the identification of de novo mutations in WDR45 that cause static encephalopathy of childhood with neurodegeneration in adulthood. WDR45 encodes a homolog of the yeast autophagy protein Atg18.

Hirotomo Saitsu
Taki Nishimura
Naomichi Matsumoto
Research24 Feb 2013
Nature Genetics

Volume: 45, P: 445-449
Fingertip advanced glycation end products and psychotic symptoms among adolescents

Mitsuhiro Miyashita
Syudo Yamasaki
Makoto Arai
ResearchOpen Access12 Aug 2021
npj Schizophrenia

Volume: 7, P: 1-6
Urinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences

Yasufumi Tomita
Kazuhiro Suzuki
Makoto Arai
ResearchOpen Access11 Mar 2023
Schizophrenia

Volume: 9, P: 1-7
Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage

Keisuke Kajita
Mitsuhiro Nishida
Michiko Mandai
ResearchOpen Access02 May 2024
Scientific Reports

Volume: 14, P: 1-11
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
Amendments and CorrectionsOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1
Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals

Masahiro Nakatochi et al. report a genome-wide meta-analysis of serum uric acid levels in the Japanese population. They identify 36 loci, including eight previously unreported loci, suggesting key cellular processes that contribute to elevated serum uric acid levels, which can lead to gout.

Masahiro Nakatochi
Masahiro Kanai
Hirotaka Matsuo
ResearchOpen Access08 Apr 2019
Communications Biology

Volume: 2, P: 1-10
Human iPS cell derived RPE strips for secure delivery of graft cells at a target place with minimal surgical invasion

Mitsuhiro Nishida
Yuji Tanaka
Michiko Mandai
ResearchOpen Access02 Nov 2021
Scientific Reports

Volume: 11, P: 1-14
The impact of graft cell source on bloodstream infection in the first 100 days after allogeneic hematopoietic cell transplantation

Shinsuke Takagi
Sho Ogura
Shuichi Taniguchi
Research19 Feb 2021
Bone Marrow Transplantation

Volume: 56, P: 1625-1634
Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV

Haruna Onoyama
Mako Kamiya
Yasuyuki Seto
ResearchOpen Access01 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
No post-transplant pure red cell aplasia development in 106 major ABO incompatible cord blood transplantation

Sachie Wada
Yuki Asano-Mori
Shuichi Taniguchi
Correspondence06 Nov 2018
Bone Marrow Transplantation

Volume: 54, P: 765-768
HHV-6 associated diseases are one of the major factors on higher early CNS complications in CB recipients than in those of BM/PBSC

Kosei Kageyama
Naoyuki Uchida
Shuichi Taniguchi
Correspondence11 Aug 2020
Bone Marrow Transplantation

Volume: 56, P: 686-688

Search

A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Blood DNA virome associates with autoimmune diseases and COVID-19

Problematic online gaming mediates the association between attention-deficit/hyperactivity and subsequent mental health issues in adolescents

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Foxd1 is a mediator and indicator of the cell reprogramming process

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Hair zinc levels and psychosis risk among adolescents

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Synthetic lateral inhibition governs cell-type bifurcation with robust ratios

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

A second update on mapping the human genetic architecture of COVID-19

Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts

Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells

Polarization-sensitive optical coherence tomography for estimating relative melanin content of autologous induced stem-cell derived retinal pigment epithelium

Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

Fingertip advanced glycation end products and psychotic symptoms among adolescents

Urinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences

Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals

Human iPS cell derived RPE strips for secure delivery of graft cells at a target place with minimal surgical invasion

The impact of graft cell source on bloodstream infection in the first 100 days after allogeneic hematopoietic cell transplantation

Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV

No post-transplant pure red cell aplasia development in 106 major ABO incompatible cord blood transplantation

HHV-6 associated diseases are one of the major factors on higher early CNS complications in CB recipients than in those of BM/PBSC

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