Nature Search

Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis

Cancer cells can be dependent on mitochondrial respiration to survive. Here, in pancreatic cancer cells, the authors show that monounsaturated fatty acids-linked ether lipids maintain mitochondrial redox homeostasis and modulate sensitivity to inhibition to electron transport chain complex I.

Ziheng Chen
I-Lin Ho
Haoqiang Ying
ResearchOpen Access17 Apr 2023
Nature Communications

Volume: 14, P: 1-15
Fine Structure of a Vesiculated Reticulum in the Light Organ of the Glow-Worm, Lampyris noctiluca

V. C. BARBER
P. N. DILLY
C. W. T. PILCHER
Research01 Mar 1965
Nature

Volume: 205, P: 1183-1185
Estimation of Mass-Scattering Coefficient of Biological Samples

N. H. SARKAR
P. SADHUKHAN
Research30 Mar 1963
Nature

Volume: 197, P: 1263-1264
Rare Breeds of Domesticated Animals Being Preserved by the Zoological Society of London

I. W. ROWLANDS
Research11 Apr 1964
Nature

Volume: 202, P: 131-132
Increased biological productivity and export production in the glacial Southern Ocean

N. Kumar
R. F. Anderson
M. Suter
Research14 Dec 1995
Nature

Volume: 378, P: 675-680
Personalized neoantigen vaccines as early intervention in untreated patients with lymphoplasmacytic lymphoma: a non-randomized phase 1 trial

Lymphoplasmacytic lymphoma is a B-cell low-grade lymphoma with no approved standard therapy. Here the authors report a non-randomized phase 1 clinical trial performing early intervention with personalized neoantigen vaccines in asymptomatic patients and associating clinical efficacy with successful perturbation of the tumor immune microenvironment.

Szymon J. Szymura
Lin Wang
Sheeba K. Thomas
ResearchOpen Access11 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

Maria Zanti
Denise G. O’Mahony
Kyriaki Michailidou
ResearchOpen Access25 May 2025
Nature Communications

Volume: 16, P: 1-18
RNA transcripts serve as a template for double-strand break repair in human cells

DNA double-stranded breaks threaten genome stability. Here, the authors show that transcript RNA serves as a repair template in human cells and identify Polζ as a key factor in RNA-templated DSB repair. This process can lead to intron deletion, resulting in a mutational signature in cancer genomes.

Manisha Jalan
Alessandra Brambati
Agnel Sfeir
ResearchOpen Access10 May 2025
Nature Communications

Volume: 16, P: 1-16
Internal rotation of the Sun

T. L. Duvall Jr
W. A. Dziembowski
J. W. Leibacher
Research05 Jul 1984
Nature

Volume: 310, P: 22-25
Aurora

JAMES S. ANDERSON
Research29 Oct 1874
Nature

Volume: 10, P: 522
Polychlorinated Biphenyls in the Global Ecosystem

R. W. RISEBROUGH
P. RIECHE
M. N. KIRVEN
Research14 Dec 1968
Nature

Volume: 220, P: 1098-1102
A Polyglycerophosphate Compound from Mycoplasma mycoides

P. PLACKETT
Research14 Jan 1961
Nature

Volume: 189, P: 125-126
Lymphocyte Mitogenic Factor in Man

R. N. MAINI
A. D. M. BRYCESON
D. C. DUMONDE
Research04 Oct 1969
Nature

Volume: 224, P: 43-44
Role of the Thymus in Neonatal Life

DELPHINE M. V. PARROTT
JUNE EAST
Research28 Jul 1962
Nature

Volume: 195, P: 347-348
Anaesthesia and Temperature Effect Mechanism in Neuromuscular Blocking By N⁺ Quaternary Depolarizing Drugs

F. G. CANEPA
Research01 Sept 1965
Nature

Volume: 207, P: 1149-1152
Comprehensive molecular characterization of mitochondrial genomes in human cancers

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Yuan Yuan
Young Seok Ju
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 342-352
Fractional quantum Hall effect in the absence of Landau levels

The fractional quantum Hall effect occurs when electrons move in Landau levels. In this study, using a theoretical flat-band lattice model, the fractional quantum Hall effect is observed in the presence of repulsive interactions when the band is one third full and in the absence of Landau levels.

D.N. Sheng
Zheng-Cheng Gu
L. Sheng
ResearchOpen Access12 Jul 2011
Nature Communications

Volume: 2, P: 1-5
Loss of p53 drives neuron reprogramming in head and neck cancer

MicroRNAs from head and neck cancer cells, shuttled to sensory neurons by extracellular vesicles, cause a shift to an adrenergic neuronal phenotype that promotes tumour progression.

Moran Amit
Hideaki Takahashi
Jeffrey N. Myers
Research12 Feb 2020
Nature

Volume: 578, P: 449-454
Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

A multi-ancestry genome-wide association meta-analysis of kidney cancer identifies 63 regions associated with disease susceptibility including one locus that was associated with increased risk in individuals with African ancestry.

Mark P. Purdue
Diptavo Dutta
Stephen J. Chanock
Research26 Apr 2024
Nature Genetics

Volume: 56, P: 809-818
Observation of Radioactive Fall-Out in Nigeria up to 1961

B. N. C. AGU
Research01 Feb 1965
Nature

Volume: 205, P: 649-651
Changes in Human Body Burdens of Gamma-Radioactivities, 1960–64

N. S. MacDONALD
M. HEPLER
A. J. STEEN
Research12 Jun 1965
Nature

Volume: 206, P: 1127-1128
Changes in Animal Tissue After Hydrocortisone Administration: Production of Dystrophic Calcification of Cardiac Muscle in Mice by Hydrocortisone

LOWELL L. SPARKS
WERNER ROSENAU
CHOH HAO LI
Research10 Sept 1955
Nature

Volume: 176, P: 503-504
Formation of discrete islands in linear island chains

John N. Skilbeck
John A. Whitehead Jr
Research06 Apr 1978
Nature

Volume: 272, P: 499-501
Evidence for a Common Structural Pattern in the Polysaccharide Sulphates of the Rhodophyceae

N. S. ANDERSON
T. C. S. DOLAN
D. A. REES
Research13 Mar 1965
Nature

Volume: 205, P: 1060-1062
Three-dimensional model of purple membrane obtained by electron microscopy

R. Henderson
P. N. T. Unwin
Research01 Sept 1975
Nature

Volume: 257, P: 28-32
Irradiation Effects on Strand Separation of Deoxyribonucleic Acid

H. M. KLOUWEN
A. W. M. APPELMAN
G. W. BARENDSEN
Research12 May 1962
Nature

Volume: 194, P: 554-555
Continental Drift before 1900

N. A. RUPKE
Research25 Jul 1970
Nature

Volume: 227, P: 349-350
Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Elodie Piot
Félix Renard
Maria Luisa Mandelli
ResearchOpen Access03 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
The fungus Armillaria bulbosa is among the largest and oldest living organisms

Myron L. Smith
Johann N. Bruhn
James B. Anderson
Research02 Apr 1992
Nature

Volume: 356, P: 428-431
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer

The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.

Sherry Y. Wu
Rajesha Rupaimoole
Anil K. Sood
ResearchOpen Access04 Apr 2016
Nature Communications

Volume: 7, P: 1-14
Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

The evolution of immune landscape in lung adenocarcinoma (ADC) is largely unknown. Here the authors use a cohort of resected invasive lung ADC and its precursors and show a gradual increase of immunosuppression and decrease of anti-tumor response associated with specific genomic and epigenetic features.

Hitoshi Dejima
Xin Hu
Jianjun Zhang
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-11
Ultrasonic Absorption in Water in the Region of I mc./s

C. E. Mulders
Research27 Aug 1949
Nature

Volume: 164, P: 347-348
Antigenicity in Mice of Antilymphocyte Gamma Globulin

E. M. LANCE
D. W. DRESSER
Research01 Jul 1967
Nature

Volume: 215, P: 488-490
Restriction of Bacteriophage Multiplication by Resistance Determinants in Salmonellae

E. S. ANDERSON
J.-S. PITTON
JUNE N. MAYHEW
Research10 Aug 1968
Nature

Volume: 219, P: 640-641
Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential

The prognostic significance of stromal cells in ovarian cancer has not been explored. Here the authors show that stromal microfibrillar-associated protein 5 (MFAP5) drives metastasis of ovarian cancer and represents a new a prognostic marker related to decreased survival.

Cecilia S. Leung
Tsz-Lun Yeung
Samuel C. Mok
Research03 Oct 2014
Nature Communications

Volume: 5, P: 1-15
CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

EZH2 phosphorylation by CDK2 promotes progression of triple-negative breast cancer (TNBC). Here, the authors show that this signaling axis downregulates ERα, and thus combinatorial blockade of CDK2 and EZH2 sensitizes TNBC cells to tamoxifen.

Lei Nie
Yongkun Wei
Mien-Chie Hung
ResearchOpen Access08 Nov 2019
Nature Communications

Volume: 10, P: 1-15
Resonant magnetic exciton mode in the heavy-fermion antiferromagnet CeB₆

Resonant magnetic excitations are common in unconventional superconductors, but the mechanism for their formation is elusive. Using inelastic neutron scattering, this study finds similar excitations in the non-superconducting heavy-fermion metal CeB₆, suggesting common behaviour between the two ground states.

G. Friemel
Yuan Li
D.S. Inosov
ResearchOpen Access15 May 2012
Nature Communications

Volume: 3, P: 1-6
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders

Bethan Jones
Emma L. Jones
Carol C. Shoulders
Research14 Apr 2003
Nature Genetics

Volume: 34, P: 29-31
Physico-Chemical Properties of Silica in Relation to its Toxicity

T. NASH
A. C. ALLISON
J. S. HARINGTON
Research01 Apr 1966
Nature

Volume: 210, P: 259-261
A visual–omics foundation model to bridge histopathology with spatial transcriptomics

OmiCLIP is a visual–omics foundation model that integrates histology and spatial transcriptomics. The associated Loki platform offers accurate and robust tools for alignment, annotation, cell-type decomposition and spatial gene expression prediction.

Weiqing Chen
Pengzhi Zhang
Guangyu Wang
ResearchOpen Access29 May 2025
Nature Methods

Volume: 22, P: 1568-1582
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma

Immunotherapies now dominate the treatment landscape for melanoma, but why they only work in a subset of patients remains unclear. Here, the authors perform an immunogenomic analysis on 67 intratumor sub-regions of a PD-1 inhibitor resistant melanoma, and 2 additional metastases from a single patient, mapping the spatial relationships between genomic and immune heterogeneity at high resolution.

Akash Mitra
Miles C. Andrews
P. Andrew Futreal
ResearchOpen Access15 Apr 2020
Nature Communications

Volume: 11, P: 1-18
Dependence of the Observed Oxygen Effect on the Post-Irradiation Treatment of Micro-Organisms

TIKVAH ALPER
N. E. GILLIES
Research05 Apr 1958
Nature

Volume: 181, P: 961-963
Ground-state oxygen holes and the metal–insulator transition in the negative charge-transfer rare-earth nickelates

Rare-earth perovskite nickelates show intriguing metal–insulator transitions, whose mechanism remains elusive. Here, Bisogni et al. evidenced a 3d⁸ Ni configuration together with abundance of oxygen 2p holes in the ground state of a NdNiO₃thin film, suggesting a negative charge-transfer scenario.

Valentina Bisogni
Sara Catalano
Thorsten Schmitt
ResearchOpen Access11 Oct 2016
Nature Communications

Volume: 7, P: 1-8
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes

This study uncovered genetic associations with environmental sensitivity in psychiatric and neurodevelopmental traits in an international collaboration using data from more than 21,000 monozygotic twins—the largest genetic study of monozygotic twin differences to date.

Elham Assary
Jonathan R. I. Coleman
Robert Keers
ResearchOpen Access10 Jun 2025
Nature Human Behaviour

Volume: 9, P: 1683-1696
Suggested Sequential Mode of Control of Changes in Cell Behaviour in Adult Bone Remodelling

R. HATTNER
B. N. EPKER
H. M. FROST
Research01 May 1965
Nature

Volume: 206, P: 489-490
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
Publisher Correction: Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial

Kari L. Kendra
Shay L. Bellasea
Antoni Ribas
Amendments and Corrections26 Aug 2025
Nature Medicine

P: 1
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Characterization of Ovine Hypothalamic Hypophysiotropic TSH-releasing Factor

ROGER BURGUS
THOMAS F. DUNN
ROGER GUILLEMIN
Research25 Apr 1970
Nature

Volume: 226, P: 321-325
Large low-field magnetoresistance in La_0.7Ca_0.3MnO₃ induced by artificial grain boundaries

N. D. Mathur
G. Burnell
M. G. Blamire
Research15 May 1997
Nature

Volume: 387, P: 266-268

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