Left ventricular hypertrabeculation or noncompaction is a myocardial abnormality frequently associated with monogenic disorders, particularly neuromuscular disorders, or with chromosomal defects. The pathogenesis of this cardiomyopathy remains unknown, and the diagnostic criteria, prognosis, and optimal treatment are under debate. In this Review, Finsterer et al. provide an update on the aetiology, pathophysiology, diagnosis, treatment, and prognosis of left ventricular hypertrabeculation.
- Josef Finsterer
- Claudia Stöllberger
- Jeffrey A. Towbin