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A pyrrolidine-based small-molecule inhibitor competes with H3K27me3 for binding to EED leading to inactivation of PRC2 and global reduction in H3K27me3 levels.

Here, the authors identify PHF6 as a dependency in SMARCB1-deficient rhabdoid cancers. Mechanistically, this study suggests a regulatory role for PHF6 in recruiting SWI/SNF complexes to enable RNA polymerase progression.

This protocol describes use of the Exomiser suite, a collection of algorithms that allow for prioritization of genes and variants from exome sequencing data for disease-gene discovery.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Here, as part of the Sherlock-Lung study, the authors profile the microbiomes of 940 lung cancers in never smokers finding no significant associations with demographic and clinical features, suggesting lung bacteria are unlikely to have a sizable role in lung cancer.

Metallic resistance of two-dimensional electron gases normally increases with temperature increasing. Here, the authors find a resistance decrease with increasing temperature at very low temperatures in two-dimensional electron metal described by Fermi liquid theory.

By taking advantage of the direct interaction between heat shock protein 90 (Hsp90) and the transcriptional repressor Bcl-6, a purine-derived inhibitor of Hsp90 selectively kills diffuse large B cell lymphomas that depend on the expression of Bcl-6 for their survival.

The ideal metal selection and atomic-level arrangement for catalysts in CO₂ hydrogenation are still uncertain. Here, copper is identified as the most effective promoter for enhancing ZnZrO_x catalysts when precisely structured into CuZn ensembles, offering new insights for designing superior catalysts for CO₂-based methanol synthesis.

Huang et al. study fractional quantum Hall (fQH) states in high-quality GaAs/AlGaAs samples. They report evidence for a fQH state at filling factor ν = 9/11, which they associate with the formation of six-flux composite fermions.

In 2D electron gases, insulating behaviour at low fractional quantum Hall filling factors is understood by the formation of an electronic Wigner solid. Here, the authors use microwave spectroscopy to evidence an electron liquid–solid mixed phase in bilayer states of GaAs/AlGaAs wide quantum wells.

Confining electrons to two dimensions can drastically alter the way they interact with each other. Here, the authors show that electrons in quantum wells can form into two distinct solid-like phases when placed in a large magnetic field.

The widespread emission of sulfur oxide gases from fossil fuel combustion presents major health risks. Here, the authors show that the selective sulfur dioxide capture performance of a metal organic framework is improved by the introduction of missing linker defects and extra-framework barium cations.

The realization of cold and dense electron–hole systems by optical excitation is hindered by the heating caused by particle recombination. Now, cold and dense electron–hole systems have been observed in heterostructures with separated electron and hole layers.

Efficient oxygen activation limits oxidative catalysis. Here, incorporating single-atom Zr into CeO₂-supported Pt catalysts creates Zr₁–O–Pt₁ structures, significantly enhancing catalytic performance via boosted surface and chemisorbed oxygen activation.

The fractional quantum Hall state at the filling factor 5/2 has been intensively studied due to its predicted non-Abelian statistics. Petrescu et al. measure the composite fermion effective mass of this state and find that it is several times larger than that in the half-filled lowest Landau level.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Many ecological studies assume that space-for-time substitution approaches can be suitable proxies for unavailable time series. Here the authors show congruence between the two approaches in the direction but not the magnitude of grassland plant and arthropod community responses to land-use intensification.

Superconductivity has been induced in 2D electron gases, but high-field interplay between it and quantum Hall edge states remains elusive. Here the authors reach this regime by growing transparent superconducting contacts in GaAs, reporting modification of resistance in the quantum Hall regime.

Previous work has shown that helical domain walls can form between states of different spin-polarization during a ferromagnetic spin transition in the fractional quantum Hall regime. Here, the authors study the transport through a single helical domain wall and find strong deviations from a simplified theory of weakly interacting edge channels.

Composite fermions emerge in the fractional quantum Hall effect. Now, it has been shown that these objects can group into bubbles and that these can order into a lattice.

Fractional quantum Hall states in 2D electron gases arise due to strong electron-electron interactions, which makes a general theoretical understanding difficult. Fu et al. present data showing the ν = 5/3 quantum Hall state has a 3/2 plateau in the diagonal resistance that has not been captured by existing models.

At the ultrafast timescale the propagation of light pulses through a dielectric material is not only determined by the envelope, but also by nonlinear interactions that evolve within one optical cycle. Here, the authors demonstrate a method to determine the subcycle-resolved delay to a probe pulse in ultrafast, high-field pump–probe experiments.

Exciton–polariton condensates have garnered interest as a means to access macroscopic displays of quantum phenomena such as Bose–Einstein condensation and superfluidity. In this work, a direct measure of the polariton–polariton interaction is obtained.

The authors report on the implementation of a photonic crystal waveguide with hyperbolic geometry supporting bound-in-the continuum exciton-polariton condensates. This unveils the coexistence of evanescent and ballistic polariton coupling behaviour with all-optical control.

Nanocatalysts can restructure during reactions. Here, the authors dynamically varied the stoichiometry of the surface species in 30 % Pd-in-Au nanoparticles by modulating H2 and O2 gases and quantified the formation kinetics of Pd regions and oxides.

The metal-organic framework TAMOF-1 offers high performance for CO₂ capture and purification from model biogas streams, thanks to its high CO₂ adsorption potential, good stability in humid conditions, and energy-efficient regeneration.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Barium tagging is a key ingredient for future detectors of neutrinoless double beta decay in low-background environments. Here, the authors demonstrate fluorescence imaging of single Ba2+ ions in high pressure Xenon gas, by comparing activity between Ba2+ chelated and unchelated samples of crown-ether chemosensors.

An ‘attoclock’ that measures the relative release time of electrons during double ionization is now presented. The technique enables investigation of the subtle differences between sequential and non-sequential ionization when elliptically polarized light is used to excite two electrons from argon atoms.

The Berezinskii–Kosterlitz–Thouless transition is observed in a 2D gas of exciton-polaritons, through measurements of the first-order coherence both in space and time.

The authors find that the Avpr1a gene, encoding the vasopressin-1A receptor, is responsible for strain-dependent pain sensitivity of mice to formalin and capsaicin. In humans, a single nucleotide polymorphism in AVPR1A was found to affect capsaicin pain and desmopressin analgesia. In both species, the effects were male specific and dependent on stress levels at the time of testing.

Richter’s Transformation is a treatment-resistant and fatal progression from Chronic Lymphocytic Leukemia (CLL) to an aggressive lymphoma. Here, the authors show that PRMT5 is upregulated months prior to and after transformation, PRMT5 overexpression in a CLL mouse model leads to increased risk of transformation, and that targeted PRMT5 inhibition prolongs survival and delays disease development.