The multipotency of adult CNS stem cells has been shown in vitro, but not in vivo. Progenitors in the adult hippocampal subgranular zone normally generate only granule neurons. Retrovirus-mediated expression of the transcription factor Ascl1, however, resulted in the generation of immature and mature oligodendrocytes, demonstrating the progenitors' latent multipotency.
- Sebastian Jessberger
- Nicolas Toni
- Fred H Gage
