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Scientific Reports (28)
Hypertension Research (7)
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Showing 1–50 of 61 results

Advanced filters: Author: Naoki Fujii Clear advanced filters

Risk stratification of acute exacerbations by autoantibodies in patients with idiopathic interstitial pneumonia

Shusuke Yazawa
Noriyuki Enomoto
Takafumi Suda
ResearchOpen Access13 Oct 2025
Scientific Reports

Volume: 15, P: 1-11
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins

Enantioselective synthesis of six-membered oxacycles with multiple stereogenic centres is essential for the discovery of new therapeutic agents. Here the authors show organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans.

Naoki Yoneda
Yuki Fujii
Seijiro Matsubara
ResearchOpen Access09 Nov 2017
Nature Communications

Volume: 8, P: 1-7
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Shoot-Silicon-Signal protein to regulate root silicon uptake in rice

Shoot-Silicon-Signal (OsFTL12) protein is expressed only in the rice shoot response to Si deficiency. Yet, the protein is also detected in phloem sap and root, stimulating the root Si uptake. This signal integrates shoot Si demand and root Si uptake.

Naoki Yamaji
Namiki Mitani-Ueno
Jian Feng Ma
ResearchOpen Access27 Dec 2024
Nature Communications

Volume: 15, P: 1-11
Acquisition of aluminium tolerance by modification of a single gene in barley

Barley is an important food crop that has been adapted to grow on acidic soils that often contain toxic soluble aluminium. In this study, an insertion in the upstream region of a citrate transporter is shown to confer resistance of barley to aluminium toxicity and is found in aluminium-tolerant barley accessions.

Miho Fujii
Kengo Yokosho
Jian Feng Ma
ResearchOpen Access06 Mar 2012
Nature Communications

Volume: 3, P: 1-9
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Analysis of the relationship between bronchoalveolar lavage lymphocyte fraction and detailed autoimmune features in patients with idiopathic interstitial pneumonia

Noriyuki Enomoto
Masayuki Watanuki
Takafumi Suda
ResearchOpen Access19 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Isohumulones Derived from Hops Ameliorate Renal Injury via an Anti-Oxidative Effect in Dahl Salt-Sensitive Rats

Tamehachi Namikoshi
Naruya Tomita
Naoki Kashihara
Research01 Feb 2007
Hypertension Research

Volume: 30, P: 175-184
Poly(1-n-octadecylpyrrole) Films with ‘Needle’-like Morphology

Hu Yan
Yutaka Hattori
Naoki Toshima
Research09 May 2007
Polymer Journal

Volume: 39, P: 652-653
UPS Spectra of the Polyacetylene Derivatives Carrying Stable Radical Substituents

Naoki Yoshioka
Hiroyuki Nishide
Kazuhiko Seki
Research01 Jul 1991
Polymer Journal

Volume: 23, P: 921-924
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Development of risk-score model in patients with negative surgical margin after robot-assisted radical prostatectomy

Yuta Yamada
Yoichi Fujii
Haruki Kume
ResearchOpen Access31 Mar 2024
Scientific Reports

Volume: 14, P: 1-9
Oxygen-evolving photosystem II structures during S₁–S₂–S₃ transitions

Serial femtosecond crystallography reveals the structural dynamics of photosystem II during the S-state transitions that produce dioxygen, providing insight into electron transfer, water insertion, proton release and O–O bond formation on sub-microsecond timescales.

Hongjie Li
Yoshiki Nakajima
Jian-Ren Shen
ResearchOpen Access31 Jan 2024
Nature

Volume: 626, P: 670-677
A polarly localized transporter for efficient manganese uptake in rice

Manganese is an essential metal for plant growth. A series of laboratory experiments suggest that metal tolerance protein 9 (MTP9), a member of the cation diffusion facilitator family, is required for manganese translocation, and thereby uptake, in rice.

Daisei Ueno
Akimasa Sasaki
Jian Feng Ma
Research09 Nov 2015
Nature Plants

Volume: 1, P: 1-8
Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides

The complexity and diversity of natural product structures make them an ideal starting point for the creation of chemical libraries. Now it is shown that a semi-synthetic process can combine heterologous expression of a multipotent biosynthetic intermediate with multiple non-enzymatic steps to produce libraries of pseudo-natural products.

Teigo Asai
Kento Tsukada
Yoshiteru Oshima
Research03 Aug 2015
Nature Chemistry

Volume: 7, P: 737-743
A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain

Copper (Cu) is an essential mineral nutrient but high concentrations in rice grain can cause toxicity. Here the authors provide evidence that natural variation in rice grain Cu concentration is caused by altered sequestration of Cu into root vacuoles due to a single amino acid substitution in the OsHMA4 transporter.

Xin-Yuan Huang
Fenglin Deng
Jian Feng Ma
ResearchOpen Access08 Jul 2016
Nature Communications

Volume: 7, P: 1-13
Improving water dispersibility and bioavailability of luteolin using microemulsion system

Ayaka Miyashita
Junya Ito
Kiyotaka Nakagawa
ResearchOpen Access13 Jul 2022
Scientific Reports

Volume: 12, P: 1-8
A pristine record of outer Solar System materials from asteroid Ryugu’s returned sample

The sample taken from carbonaceous asteroid Ryugu and brought back to Earth by the Hayabusa2 spacecraft contains outer Solar System-derived materials uncontaminated by terrestrial processes. Even CI carbonaceous chondrites, despite their closeness to solar abundances, are not pristine.

Motoo Ito
Naotaka Tomioka
Yuichi Tsuda
ResearchOpen Access15 Aug 2022
Nature Astronomy

Volume: 6, P: 1163-1171
MicroRNAs profiling in fibroblasts derived from patients with Gorlin syndrome

Tadashi Shiohama
Katsunori Fujii
Naoki Shimojo
Research14 May 2019
Journal of Human Genetics

Volume: 64, P: 757-765
The actual electronic band structure of a rubrene single crystal

Jun Nitta
Kazumoto Miwa
Kazuyuki Sakamoto
ResearchOpen Access04 Jul 2019
Scientific Reports

Volume: 9, P: 1-7
Breeding for low cadmium barley by introgression of a Sukkula-like transposable element

The primary source of human exposure to the highly toxic heavy metal cadmium (Cd) is diet. This study identified a gene encoding a P-type heavy metal ATPase 3 (HvHMA3) that is responsible for Cd accumulation in barley grain. A Sukkula-like transposable element was found to play an important role in upregulating the expression of HvHMA3, thereby decreasing Cd accumulation in the grain.

Gui Jie Lei
Miho Fujii-Kashino
Jian Feng Ma
Research13 Aug 2020
Nature Food

Volume: 1, P: 489-499
Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells

Naomi Nakamura
Masahiro Fujii
Naoki Yamamoto
Research28 Apr 1999
Oncogene

Volume: 18, P: 2667-2675
Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts

Keiichi Hirono
Yukiko Hata
Fukiko Ichida
ResearchOpen Access16 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Differences in target organ damage between captopril challenge test-defined definitive-positive and borderline-range groups among patients with primary aldosteronism

Naoki Fujiwara
Tatsuya Haze
Michio Otsuki
Research15 Oct 2024
Hypertension Research

Volume: 48, P: 540-552
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Derived neutrophil-to-lymphocyte ratio has the potential to predict safety and outcomes of durvalumab after chemoradiation in non-small cell lung cancer

Akira Sugimoto
Hiroyasu Kaneda
Tomoya Kawaguchi
ResearchOpen Access23 Aug 2024
Scientific Reports

Volume: 14, P: 1-11
Early detection of pancreatic cancer by comprehensive serum miRNA sequencing with automated machine learning

Munenori Kawai
Akihisa Fukuda
Hiroshi Seno
ResearchOpen Access28 Aug 2024
British Journal of Cancer

Volume: 131, P: 1158-1168
Comparable outcomes with 14-, 21-, or standard 28-day venetoclax in the first cycle of azacitidine–venetoclax in untreated acute myeloid leukemia: real-world experience from the Hokkaido Leukemia Net

Minoru Kanaya
Masahiro Onozawa
Takanori Teshima
CorrespondenceOpen Access03 Jul 2025
Blood Cancer Journal

Volume: 15, P: 1-4
Angiotensin II Type 1 Receptor Blocker Attenuates Myocardial Remodeling and Preserves Diastolic Function in Diabetic Heart

Hiroyuki Tsutsui
Shouji Matsushima
Kenji Sunagawa
Research01 May 2007
Hypertension Research

Volume: 30, P: 439-449
Predictors of confirmatory test results for the diagnosis of primary hyperaldosteronism in hypertensive patients with an aldosterone-to-renin ratio greater than 20. The SHRIMP study

Ryuji Okamoto
Masaya Taniguchi
Masaaki Ito
Research06 Nov 2018
Hypertension Research

Volume: 42, P: 40-51
Enhanced expression of dystrophin, IGF-1, CD44 and MYH3 in plasma and skeletal muscles including diaphragm of mdx mice after oral administration of Neu REFIX beta 1,3-1,6 glucan

Senthilkumar Preethy
Shuji Sakamoto
Samuel JK Abraham
ResearchOpen Access28 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

Satoshi Umemura
Hisatomi Arima
Nobuhito Hirawa
Reviews02 Aug 2019
Hypertension Research

Volume: 42, P: 1235-1481
Current status of the rapid decline in renal function due to diabetes mellitus and its associated factors: analysis using the National Database of Health Checkups in Japan

Makoto Fujii
Yuko Ohno
Mai Kabayama
ResearchOpen Access02 Feb 2023
Hypertension Research

Volume: 46, P: 1075-1089
Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study

Sho Suzuki
Naoyuki Tominaga
Naoyoshi Nagata
ResearchOpen Access17 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Establishment of a Gorlin syndrome model from induced neural progenitor cells exhibiting constitutive GLI1 expression and high sensitivity to inhibition by smoothened (SMO)

The hedgehog pathway is pivotal in basal cell carcinoma and medulloblastoma development. Gorlin syndrome-derived, induced pluripotent stem cells (iPSCs) carrying a heterozygous mutation in PTCH1, a hedgehog target gene, exhibited high GLI1 expression and enhanced sensitivity to a hedgehog pathway inhibitor after neural differentiation. These iPSCs can serve as a model for hedgehog pathway-related tumors.

Hajime Ikehara
Katsunori Fujii
Akihiro Umezawa
Research22 Nov 2019
Laboratory Investigation

Volume: 100, P: 657-664
Protein co-expression network-based profiles revealed from laser-microdissected cancerous cells of lung squamous-cell carcinomas

Toshihide Nishimura
Kiyonaga Fujii
Hisashi Saji
ResearchOpen Access12 Oct 2021
Scientific Reports

Volume: 11, P: 1-15
Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction: report from the Hokkaido acute myocardial infarction registry

Hiroki Satoh
Naoki Ishimori
Hiroyuki Tsutsui
Research19 Jan 2012
Hypertension Research

Volume: 35, P: 463-469
A novel prediction tool for mortality in patients with acute lower gastrointestinal bleeding requiring emergency hospitalization: a large multicenter study

Naoyuki Tominaga
Eiji Sadashima
Naoyoshi Nagata
ResearchOpen Access04 Mar 2024
Scientific Reports

Volume: 14, P: 1-14
Identification of miRNAs in cervical mucus as a novel diagnostic marker for cervical neoplasia

Satoshi Kawai
Takuma Fujii
Aya Iwata
ResearchOpen Access04 May 2018
Scientific Reports

Volume: 8, P: 1-11
Disease-related cellular protein networks differentially affected under different EGFR mutations in lung adenocarcinoma

Toshihide Nishimura
Haruhiko Nakamura
Hisashi Saji
ResearchOpen Access02 Jul 2020
Scientific Reports

Volume: 10, P: 1-16
A proteogenomic profile of early lung adenocarcinomas by protein co-expression network and genomic alteration analysis

Toshihide Nishimura
Haruhiko Nakamura
Hisashi Saji
ResearchOpen Access12 Aug 2020
Scientific Reports

Volume: 10, P: 1-13
Natural glass alteration under a hyperalkaline condition for about 4000 years

Ryosuke Kikuchi
Tsutomu Sato
Carlo A. Arcilla
ResearchOpen Access26 Sept 2022
Scientific Reports

Volume: 12, P: 1-10
Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study

Tadashi Shiohama
Aya Hisada
Takahiko Katoh
ResearchOpen Access23 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice

Takujiro Homma
Toshihiro Kurahashi
Junichi Fujii
ResearchOpen Access21 Oct 2020
Scientific Reports

Volume: 10, P: 1-12
Outcomes in high and low volume hospitals in patients with acute hematochezia in a cohort study

Naoki Ishii
Naoyoshi Nagata
Mitsuru Kaise
ResearchOpen Access13 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
The FibroScan-aspartate aminotransferase score can stratify the disease severity in a Japanese cohort with fatty liver diseases

Hideki Fujii
Shinya Fukumoto
Norifumi Kawada
ResearchOpen Access05 Jul 2021
Scientific Reports

Volume: 11, P: 1-9

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