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Showing 1–50 of 527 results
Advanced filters: Author: Nicola McCarthy Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

    • Lamorna Brown
    • Nicola McCarthy
    News & Views
    Nature
    Volume: 387, P: 450-451

  • Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.

    • Gabriel Balmus
    • Delphine Larrieu
    • Stephen P. Jackson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 7, P: 228

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 8, P: 76-77

  • Looking at the effects of proteins encoded by DNA tumour viruses on the host genome could aid the interpretation of high-throughput sequencing data from cancer samples.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 582

  • The DNA repair protein 53BP1 marks regions of under-replicated DNA in the G1 phase of the cell cycle.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 11, P: 233

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 9, P: 229

  • Signals from EphB receptors that trigger cell proliferation and migration are mediated by two distinct downstream pathways.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 10, P: 4

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 7, P: 569

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 9, P: 383

    • Nicola McCarthy
    Comments & Opinion
    Nature Reviews Cancer
    Volume: 6, P: S14-S15

  • Kyle Gaulton, Mark McCarthy, Andrew Morris and colleagues report fine mapping and genomic annotation of 39 established type 2 diabetes susceptibility loci. They find that the set of potential causal variants is enriched for overlap with FOXA2 binding sites in human islet and liver cells, and they show that a likely causal variant near MTNR1B increases FOXA2-bound enhancer activity, providing a molecular mechanism to explain the effect of this locus on disease risk.

    • Kyle J Gaulton
    • Teresa Ferreira
    • Andrew P Morris
    Research
    Nature Genetics
    Volume: 47, P: 1415-1425

  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 520

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 520

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 823

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 520

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 794

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 297

  • A new drug shows promise for patients with triple-negative breast cancer.

    • Nicola McCarthy
    News
    Nature Reviews Cancer
    Volume: 13, P: 439

  • This Resource presents the genetic subset of the 136,000 chemical and genetic perturbations tested by the Joint Undertaking for Morphological Profiling (JUMP) Cell Painting Consortium and associated analysis of phenotypic profiles.

    • Srinivas Niranj Chandrasekaran
    • Eric Alix
    • Anne E. Carpenter
    Research
    Nature Methods
    Volume: 22, P: 1742-1752

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 8, P: 904-905

  • Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

    • David W Clark
    • Yukinori Okada
    • James F Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

    • Harald S. Vöhringer
    • Theo Sanderson
    • Moritz Gerstung
    ResearchOpen Access
    Nature
    Volume: 600, P: 506-511

  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282

  • Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

    • Dami A. Collier
    • Anna De Marco
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 593, P: 136-141

    • Alison Farrell
    • Ezzie Hutchinson
    • Nicola McCarthy
    Editorial
    Nature Research

  • The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

    • Brian J. Willett
    • Joe Grove
    • Emma C. Thomson
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 1161-1179

  • In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [177Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [177Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

    • Edmond M. Kwan
    • Sarah W. S. Ng
    • Alison Y. Zhang
    Research
    Nature Medicine
    Volume: 31, P: 2722-2736

  • Sequencing data from two large-scale studies show that most of the genetic variation influencing the risk of type 2 diabetes involves common alleles and is found in regions previously identified by genome-wide association studies, clarifying the genetic architecture of this disease.

    • Christian Fuchsberger
    • Jason Flannick
    • Mark I. McCarthy
    Research
    Nature
    Volume: 536, P: 41-47

  • Low read depth sequencing of whole genomes and high read depth exomes of nearly 10,000 extensively phenotyped individuals are combined to help characterize novel sequence variants, generate a highly accurate imputation reference panel and identify novel alleles associated with lipid-related traits; in addition to describing population structure and providing functional annotation of rare and low-frequency variants the authors use the data to estimate the benefits of sequencing for association studies.

    • Klaudia Walter
    • Josine L. Min
    • Weihua Zhang
    ResearchOpen Access
    Nature
    Volume: 526, P: 82-90

  • Whole-genome sequencing indicates few genetic changes in retinoblastoma and hints at epigenetic changes instead.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 80

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 8, P: 833

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 441

  • Two papers have been published inNaturethat analyse genomic and transcriptomic changes in breast tumours to further understand the biology of breast cancer.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 375

  • A recent publication inNature Medicine in which Seyedmehdi Shojaee, Markus Müschen and colleagues show that deletion of the tumour suppressor PTENin pre-B cell acute lymphoblastic leukaemia (pre-B ALL) cells results in cell death.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 16, P: 272-273

  • A paper published inNature Physicshas experimentally and mathematically modelled epithelial cell migration and identified mechanically generated waves that are important for cellular motility.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 510