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Showing 1–13 of 13 results
Advanced filters: Author: Niklas Mejhert Clear advanced filters

  • Lecoutre, Maqdasy and Rizo-Roca show that whole-body pharmacological inhibition or adipocyte-specific deletion of glutaminase in mice activates thermogenesis in inguinal adipocytes and promotes metabolic health. They also link decreased plasma and adipose tissue glutamine-to-glutamate ratios to insulin resistance in humans with obesity.

    • Simon Lecoutre
    • Salwan Maqdasy
    • Mikael Rydén
    ResearchOpen Access
    Nature Metabolism
    Volume: 6, P: 1329-1346

  • Single-cell studies of human white adipose tissue (WAT) provide insights into the specialized cell types in the tissue. Here the authors combine publicly available and newly generated high-resolution and bulk transcriptomic results from multiple human datasets to provide a comprehensive cellular map of white adipose tissue.

    • Lucas Massier
    • Jutta Jalkanen
    • Niklas Mejhert
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Maqdasy, Lecoutre et al. show that increased an phosphocreatine/creatine ratio in white adipocytes drives changes in AMP-activated protein kinase activity and promotes white adipocyte inflammation during obesity.

    • Salwan Maqdasy
    • Simon Lecoutre
    • Mikael Rydén
    ResearchOpen Access
    Nature Metabolism
    Volume: 4, P: 190-202

  • Klingelhuber, Frendo-Cumbo et al. develop a proteomic atlas elucidating the intracellular spatiotemporal changes in protein levels and localizations during human adipogenesis.

    • Felix Klingelhuber
    • Scott Frendo-Cumbo
    • Natalie Krahmer
    ResearchOpen Access
    Nature Metabolism
    Volume: 6, P: 861-879

  • Nelson and colleagues compare whole body, skeletal muscle and white adipose tissue insulin resistance in inbred mouse strains fed a chow or a Western diet. They report large strain-related differences in diet-induced effects on weight gain and insulin action, and demonstrate that tissue-specific insulin sensitivity can be disentangled from systemic insulin resistance.

    • Niklas Mejhert
    • Mikael Rydén
    News & Views
    Nature Reviews Endocrinology
    Volume: 18, P: 269-270

  • Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to the problematic ‘yo-yo’ effect often seen with dieting.

    • Laura C. Hinte
    • Daniel Castellano-Castillo
    • Ferdinand von Meyenn
    ResearchOpen Access
    Nature
    Volume: 636, P: 457-465

  • In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.

    • Anne Loft
    • Margo P. Emont
    • Evan D. Rosen
    Reviews
    Nature Metabolism
    Volume: 7, P: 875-894

  • Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

    • Mathys Grapotte
    • Manu Saraswat
    • Charles-Henri Lecellier
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • A study from the FANTOM consortium using single-molecule cDNA sequencing of transcription start sites and their usage in human and mouse primary cells, cell lines and tissues reveals insights into the specificity and diversity of transcription patterns across different mammalian cell types.

    • Alistair R. R. Forrest
    • Hideya Kawaji
    • Yoshihide Hayashizaki
    Research
    Nature
    Volume: 507, P: 462-470