Despite advances in treatment approaches for patients with high-grade glioma, the overall prognosis remains poor. In this article, Castellino and Durden highlight the important role of angiogenesis in the pathogenesis of brain tumors, and discuss the development of new therapies that target angiogenesis in high-grade glioma by regulating the activity of the PI3K–Akt–PTEN signaling node.
- Robert C Castellino
- Donald L Durden