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Material fatigue is the most common source behind failures of mechanical structures. Here the authors combine transmission electron microscopy, high-resolution electron backscatter diffraction and discrete dislocation plasticity modeling to study the underlying mechanism of dwell fatigue in titanium alloys.

Lipid biomarker and stable carbon isotope analysis of absorbed food residues in prehistoric pottery from the Libyan Sahara has identified the first adoption of dairying practices in Neolithic Africa in the fifth millennium bc.

Colorectal tumors with mutated KRAS and APC require the amino acid transporter SLC7A5 to drive tumorigenesis. Mechanistically, SLC7A5 drives transcriptional and metabolic reprogramming by maintaining intracellular amino acid levels, leading to enhanced protein synthesis.

River capture acts as one river steals the neighboring headwaters, which is a dramatic natural process for mountain landscapes evolution. Here the authors show a stream piracy reversed flow in a major river resulting in waterfall formation, bedrock gorge incision, and widespread topographic disequilibrium.

A personalized letter from the Medical Examiner-Coroner in Los Angeles County has proven effective at reducing opioid and benzodiazepine prescribing. Here the authors show that the introduction of if/when-then planning prompts in to the letter further reduced opioid prescribing by 12.85% and benzodiazepine prescribing by 8.32%; they were most effective for clinicians with multiple patient deaths due to accidental opioid-related overdose.

Use of an enhanced suite of marine ecosystem models and Earth system model outputs from Phase 6 of the Coupled Model Intercomparison Project (CMIP6) reveals greater decline in mean global ocean animal biomass than previously projected under both strong-mitigation and high-emissions scenarios.

The authors model the role of algal symbiont shuffling and evolution in coral resilience to warming and ocean acidification, globally. They find that shuffling is more effective than evolution, and show global patterns of vulnerability due to the interaction of warming rate and adaptive capacity.

The gluonic gravitational form factor of the proton was determined using various models, and these analyses showed that the mass radius of the proton was smaller than the electric charge radius.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

Experiments at the Joint European Torus tokamak show improved thermal ion confinement in the presence of highly energetic ions and Alfvénic instabilities in the plasma.

Glaciers in the Karakoram mountains have been stable in mass, whereas in nearby regions, mass loss has prevailed. Climate model simulations reveal a unique seasonal cycle in Karakoram snowfall that contributes to this pattern.

Physical and biogeochemical changes in the Southern Ocean over the past decade are largely due to growing meltwater input and intensifying poleward winds, according to observations from ships and floats and model simulations.

Triggering and sustaining fusion reactions — with the goal of overall energy production — in a tokamak plasma requires efficient heating. Radio-frequency heating of a three-ion plasma is now experimentally shown to be a potentially viable technique.

The components of the ocean carbon cycle will respond differently to climate change, with anthropogenic impacts first seen on processes sensitive to chemical changes—the calcium carbonate pump and oceanic uptake of CO₂—with the soft-tissue pump (sensitive to the ocean’s physical state) emerging later.

Analysis of the sub-seasonal patterns of river migration reveals that permafrost reduces erosion rates and suggests that full permafrost thaw may lead to a 30–100% increase in the migration rates of Arctic rivers.

The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.

Small, spouted vessels found in Bronze and Iron Age graves of infants in Bavaria were used to feed the milk of domesticated animals to infants.

Global ocean oxygen concentrations have been declining, with rates varying regionally. The retreat of the Labrador Current, allowing more low-oxygen subtropical waters to the coastal and shelf waters, drives the rapid decline observed in the northwest Atlantic Ocean.

High atmospheric concentrations of isoprene have been observed in the Southern Ocean. The authors investigate their potential marine sources and show how these emissions impact the modelling of atmospheric processes and composition in remote environments.

The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

Tendencies towards climate-change-induced continental drying, as characterized by offline-computed runoff and other potential-evapotranspiration-dependent metrics, may be artefactual. Consequently they may be much weaker and less extensive than previously thought.

Using lipid residues absorbed in potsherds, the ages of pottery from various archaeological sites are determined and validated using sites for which the dates are well known from other methods.

Alpine topography in Europe has been shaped by recent glaciations. Cosmogenic dating of summits in Svalbard suggest that Arctic alpine topography is a million years old and that subsequent glaciations have preserved rather than eroded the landscape.

How Polycomb repressive complex 2 (PRC2) is recruited to active chromatin to mediate transcriptional silencing during lineage specification in metazoans has been unclear. New findings now show that PRC2 component PHF19, which associates with the H3K36me3 demethylase NO66, binds the active chromatin mark H3K36me3 through its Tudor domain, leading to PRC2-mediated H3K27 trimethylation, loss of H3K36me3 and transcriptional silencing.

The growth rates of freshly formed aerosol particles influence what fraction of these can reach sizes large enough to affect cloud formation and climate. Here, the authors show that the nano-particle growth in a sulphuric acid containing system can be enhanced by the presence of ions or small acid-base clusters.

Numerous marine ecosystem models are used to project animal biomass over time but integrating them can be challenging. Here the authors develop a test for statistical significance in multi-model ensemble trends, and thus relate future biomass trends to current patterns of ecological and socioeconomic status.

Genome sequence data from colorectal tumours show how adenomas progress to carcinomas on the fitness landscape.

Malliri and colleagues demonstrate that an apicobasal Rac activity gradient at cell–cell junctions is important for tight-junction assembly and establishment of apicobasal polarity. They show that this gradient is generated by the distinct spatial regulation of the Rac activator Tiam1 by β2-syntrophin and Par-3.

Climate change scenarios predict an average sea surface temperature rise of 1–6 °C by 2100. Now, a study investigating the potential effect of these changes on the distribution and diversity of marine top predators finds that, based on data from electronic tags on 23 marine species, a change in core habitat range of up to 35% is possible for some species by 2100.

Power exhaust is one of the biggest challenges stopping fusion energy. This article shows experimental evidence for strategically shaping the power exhaust region as a solution to this challenge, utilising physics understanding to strike a balance between engineering complexity and power exhaust benefits, consistent with reduced models and simulations.