Chiral scaffolds are essential to the advancement of asymmetric synthesis, yet the development of new, privileged motifs that more effectively communicate asymmetry constitutes a challenge. Here the authors report the synthesis of enantiopure indole-based axially spirocyclic scaffolds, and their application as organocatalysts or ligands in asymmetric reactions.
- Junshan Lai
- Benjamin List
- Jolene P. Reid
