Nature Search

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

E. H. Corder
A. M. Saunders
M. A. Pericak-Vance
Research01 Jun 1994
Nature Genetics

Volume: 7, P: 180-184
Functionally enriched human polymorphisms associate to species in the chronic wound microbiome

Rebecca A. Gabrilska
Khalid Omeir
Caleb D. Phillips
ResearchOpen Access09 Oct 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-13
Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition

Patients with different small round cell sarcoma (SRCS) often receive the same treatment regimen but for some SRCS subtypes, response to chemotherapy is poor and targeted treatment options are limited. Here, the authors establish a biobank of paediatric patient-derived SRCS tumoroids and perform drug screening, identifying MCL inhibition as a potential therapeutic strategy in CIC::DUX4 sarcomas.

Femke C. A. S. Ringnalda
Gijs J. F. van Son
Hans Clevers
ResearchOpen Access21 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Patient-derived tumoroids from CIC::DUX4 rearranged sarcoma identify MCL1 as a therapeutic target

Despite their differences, the rarer sarcoma CIC::DUX4 sarcoma (CDS) is typically treated with therapies developed for Ewing Sarcoma (EwS) with limited success. Here, the authors develop a co-clinical drug response profiling platform to establish patient-derived CDS and EwS tumoroids, identifying MCL1 inhibition as a promising therapeutic approach in CDS.

Willemijn Breunis
Eva Brack
Marco Wachtel
ResearchOpen Access21 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A consensus guide to preclinical indirect calorimetry experiments

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Alexander S. Banks
David B. Allison
Juleen R. Zierath
Reviews24 Sept 2025
Nature Metabolism

Volume: 7, P: 1765-1780
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
An mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite for cancer immunotherapy

Hydrogel materials have emerged as versatile platforms for biomedical applications. Here this group reports an mRNA lipid nanoparticle-incorporated microgel matrix for immune cell recruitment/antigen expression and presentation/cellular interaction thereby eliciting antitumor efficacy with a single dose.

Yining Zhu
Zhi-Cheng Yao
Hai-Quan Mao
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy

The relationship between pathogenic germline variation, clonal hematopoiesis (CH) and risk of hematologic malignancy is explored in 731,835 individuals across 6 cohorts. Carriers of variants in certain genes show distinct patterns of CH and increased risk of CH progression to malignancy.

Jie Liu
Duc Tran
Kelly L. Bolton
ResearchOpen Access15 Jul 2025
Nature Genetics

Volume: 57, P: 1872-1880
Respiratory viral infections awaken metastatic breast cancer cells in lungs

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological data from two large human cohorts.

Shi B. Chia
Bryan J. Johnson
James DeGregori
ResearchOpen Access30 Jul 2025
Nature

Volume: 645, P: 496-506
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Human contributions to global soundscapes are less predictable than the acoustic rhythms of wildlife

Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

Panu Somervuo
Tomas Roslin
Otso Ovaskainen
ResearchOpen Access09 Jul 2025
Nature Ecology & Evolution

Volume: 9, P: 1585-1598
Novel approaches to the stratified management of knee osteoarthritis

This Perspective article discusses the stratification of patients with knee osteoarthritis (OA) in the context of current guidelines, biomarkers and emerging and future developments of targeted treatment. The authors aim to highlight how these novel developments can enhance the stratification of patients with knee OA to improve patient outcomes.

Nicholas R. Fuggle
Roland Chapurlat
Nicholas C. Harvey
Reviews03 Oct 2025
Nature Reviews Rheumatology

P: 1-12
Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

Gilles David
Nacer Abbas
Alexis Brice
Research01 Sept 1997
Nature Genetics

Volume: 17, P: 65-70
Comparing neutralizing antibody activity over time between naïve and convalesced COVID-19 vaccinated individuals

Lisette de Pillis
Rebecca Caffrey
Stephen A. Varvel
ResearchOpen Access06 Oct 2025
Scientific Reports

Volume: 15, P: 1-15
Localization of Acyl Carrier Protein in Escherichia coli

H. VAN DEN BOSCH
JOSEPH R. WILLIAMSON
P. ROY VAGELOS
Research24 Oct 1970
Nature

Volume: 228, P: 338-341
Impacts of land use and land cover changes on carbon stocks (1992–2052) Using geospatial technologies in Gena district, Southwest Ethiopia

Ginjo Gitima
Tesfaye Tadesse
Menberu Teshome
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-17
High Energy Neutrons from the Sun

R. R. DANIEL
GEORGE JOSEPH
R. SUNDERRAJAN
Research07 Jan 1967
Nature

Volume: 213, P: 21-23
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism

Glutarate rewires cell metabolism through conjugation to proteins or fatty acids, but how glutarylation is regulated is unclear. ABHD11 was identified as a lipoyl-deglutarylase to maintain the TCA cycle and mitochondrial metabolism.

Guinevere L. Grice
Eleanor Minogue
James A. Nathan
ResearchOpen Access15 Jul 2025
Nature Chemical Biology

P: 1-12
Diffusing protein binders to intrinsically disordered proteins

Using RFdiffusion, a general method for targeting intrinsically disordered proteins and regions for protein design has been developed.

Caixuan Liu
Kejia Wu
David Baker
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 809-817
COVID-19 and chronic liver disease: results from the 1219 patients French registry

L. Blaise
F. Lebossé
J. Dumortier
ResearchOpen Access07 Oct 2025
Scientific Reports

Volume: 15, P: 1-10
Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Elodie Piot
Félix Renard
Maria Luisa Mandelli
ResearchOpen Access03 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
Deciphering the genome structure and paleohistory of Theobroma cacao

Cristian Chaparro
Florent Murat
Mathilde Allegre
ResearchOpen Access16 Sept 2010
Nature Precedings

P: 1
Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans

C elegans is a model organism for life span research, and mitochondrial translation has been identified as a key process affecting longevity. Here authors show that the previously identified proteostasis is not the only mechanism that defines longevity induced by mitochondrial translation inhibition, but also C32E8.9-induced lipid remodelling and immune responses.

Iman Man Hu
Marte Molenaars
Riekelt H. Houtkooper
ResearchOpen Access02 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patients

Patrick Aebischer
Myriam Schluep
E. Edward Baetge
Research01 Jun 1996
Nature Medicine

Volume: 2, P: 696-699
Author Correction: PPP2R1A mutations portend improved survival after cancer immunotherapy

Yibo Dai
Anne Knisely
Amir A. Jazaeri
Amendments and CorrectionsOpen Access05 Sept 2025
Nature

Volume: 645, P: E10
Unveiling the molecular and immunological drivers of antibody–drug conjugates in cancer treatment

Antibody–drug conjugates are rapidly expanding both in the clinical treatment of cancer and in preclinical development. In this Review, Zippelius et al. highlight the molecular interactions and immune system effects of these sophisticated drugs that drive their efficacy and toxicity.

Alfred Zippelius
Sara M. Tolaney
Greg M. Thurber
Reviews02 Oct 2025
Nature Reviews Cancer

P: 1-20
Importance of Sex Chromatin in Identifying Placental Type: A Note on Hæmochorial Placental Type of the Mink (Mustela vison) and the Dog (Canis familiaris)

Z. P. ZHEMKOVA
Research09 May 1964
Nature

Volume: 202, P: 568-570
Biomass burning as a source of atmospheric gases CO, H₂, N₂O, NO, CH₃Cl and COS

Paul J. Crutzen
Leroy E. Heidt
Wolfgang Seiler
Research15 Nov 1979
Nature

Volume: 282, P: 253-256
PPP2R1A mutations portend improved survival after cancer immunotherapy

Inactivating PPP2R1A mutations correlate with better survival after immune checkpoint blockade in patients with ovarian clear cell carcinoma, suggesting that targeting the phosphatase 2A (PP2A) pathway may represent an effective startegy for improving responses to immunotherapy.

Yibo Dai
Anne Knisely
Amir A. Jazaeri
ResearchOpen Access02 Jul 2025
Nature

Volume: 644, P: 537-546
The postbiotic ReFerm® versus standard nutritional support in advanced alcohol-related liver disease (GALA-POSTBIO): a randomized controlled phase 2 trial

Impaired gut barrier function is a central driver of alcohol-related liver disease. This study indicates that the postbiotic ReFerm® improves gut barrier function and reduce liver stiffness and liver fibrosis, suggesting the gut barrier function as a potential treatment target.

Johanne K. Hansen
Mads Israelsen
Aleksander Krag
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Evidence of Fire in South African Cave Deposits

KENNETH P. OAKLEY
Research07 Aug 1954
Nature

Volume: 174, P: 261-262
Television Microscopy: A Flying-spot Interference Television Microscope

P. O'B. MONTGOMERY
L. L. HUNDLEY
Research16 Dec 1961
Nature

Volume: 192, P: 1059-1060
Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Sooji Lee
Yejun Son
Nicholas. J. Kassebaum
Research22 Apr 2025
Nature Medicine

Volume: 31, P: 1809-1829
Same species, different prerequisites: investigating body condition and foraging success in young reef sharks between an atoll and an island system

Ornella C. Weideli
Ian A. Bouyoucos
Serge Planes
ResearchOpen Access17 Sept 2019
Scientific Reports

Volume: 9, P: 1-11
Threat reduction must be coupled with targeted recovery programmes to conserve global bird diversity

Projections of extinctions of bird species and losses of functional diversity over the next 100 years suggest that even immediate and widespread threat abatement would be insufficient to prevent losses, and targeted recovery programmes must also be implemented to conserve avian diversity.

Kerry Stewart
Chris Venditti
Manuela González-Suárez
ResearchOpen Access24 Jun 2025
Nature Ecology & Evolution

Volume: 9, P: 1499-1511
Structure and sequence of the multihaem cytochrome c₃

R. Haser
M. Pierrot
J. Le Gall
Research20 Dec 1979
Nature

Volume: 282, P: 806-810
Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation

In CHIP, somatic mutations in a hematopoietic stem cell lead to a clonal subpopulation of blood cells. Here, the authors perform a CHIP meta-EWAS to establish its epigenetic features and age-related outcomes.

Sara Kirmani
Tianxiao Huan
Daniel Levy
ResearchOpen Access20 May 2025
Nature Communications

Volume: 16, P: 1-14
Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups

This study shows how including different ancestry groups in a genome-wide association study for prostate-specific antigen levels can improve prostate cancer risk prediction, with implications for population screening.

Thomas J. Hoffmann
Rebecca E. Graff
John S. Witte
ResearchOpen Access10 Feb 2025
Nature Genetics

Volume: 57, P: 334-344
Extreme weather event attribution predicts climate policy support across the world

Literature produced inconsistent findings regarding the links between extreme weather events and climate policy support across regions, populations and events. This global study offers a holistic assessment of these relationships and highlights the role of subjective attribution.

Viktoria Cologna
Simona Meiler
Amber Zenklusen
ResearchOpen Access01 Jul 2025
Nature Climate Change

Volume: 15, P: 725-735
Anti-Antibody or Clone-Product?

P. G. H. GELL
A. S. KELUS
Research15 Feb 1964
Nature

Volume: 201, P: 687-689
Source of the Gastric Mucosal Potential Difference

J. G. FORTE
P. H. ADAMS
R. E. DAVIES
Research02 Mar 1963
Nature

Volume: 197, P: 874-876
High-entropy RuO₂ catalyst with dual-site oxide path for durable acidic oxygen evolution reaction

Developing durable catalysts for the acidic oxygen evolution reaction is crucial for proton exchange membrane water electrolyzers. Here, the authors report incorporating high-entropy atoms (Co, Ni, Cu, Mn, Sm) into RuO₂ via annealing, achieving stable operation at 1 A cm⁻² and 50 °C for 1500 h.

Fangren Qian
Dengfeng Cao
Li Song
ResearchOpen Access26 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Sr isotopic fractionation in Ca–Al inclusions from the Allende meteorite

P. J. Patchett
Research31 Jan 1980
Nature

Volume: 283, P: 438-441
Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci

Hanfei Xu
Shreyash Gupta
Ching-Ti Liu
ResearchOpen Access26 Sept 2025
International Journal of Obesity

P: 1-12
Mitochondrial and Cytoplasmic Enzymes for the Reduction of Fumarate to Succinate in Yeast

CRISTIANO ROSSI
JOSEPH HAUBER
THOMAS P. SINGER
Research10 Oct 1964
Nature

Volume: 204, P: 167-170
Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

Huaxi Xu
Gunnar K. Gouras
Sam Gandy
Research01 Apr 1998
Nature Medicine

Volume: 4, P: 447-451
Closed-loop vagus nerve stimulation aids recovery from spinal cord injury

Following spinal cord injury, gamified physical therapy that incorporates closed-loop vagus nerve stimulation can aid restoration of arm and hand function.

Michael P. Kilgard
Joseph D. Epperson
Robert L. Rennaker
ResearchOpen Access21 May 2025
Nature

Volume: 643, P: 1030-1036
Peripheral expansion of pre-existing mature T cells is an important means of CD4⁺ T-cell regeneration HIV-infected adults

Robert E. Walker
Charles S. Carter
H. Clifford Lane
Research01 Jul 1998
Nature Medicine

Volume: 4, P: 852-856

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