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The authors observed the electric field-induced generation and manipulation of topological spin textures at the monolayer limit using the topological magneto-optical effect.

Photocatalytic four-component reaction is a green and efficient synthetic strategy. Here, the authors report a series of covalent organic frameworks via the photocatalytic four-component reaction, which are used for photocatalysis.

Interfacial charge transfer limits fast-charging sodium-ion batteries. Here, authors demonstrate a P2-type positive electrode that utilizes potential-dependent anion-specific adsorption to accelerate charge transfer, enabling high-rate capability and stable cycling in Ah-scale pouch cells.

Here, the authors report the synthesis of high-κ ionic dielectric Sb₄O₅Cl₂ thin films with aligned ionic channels, showing their application for the realization of high-performance 2D MoS₂ transistors with programmable non-volatile memory and synaptic behaviours enabled by the controllable ionic migration in Sb₄O₅Cl₂.

Cationic amino acids are essential to protein synthesis and cellular signaling. Here, authors determine the structure of the cationic amino acid transporter 1 and determined how it is co-opted as a receptor for leukemia-causing animal viruses.

Here the authors engineer dual spillover of H* and CO* on PdHx/Cu to enhance urea electrosynthesis, where CO* spillover from PdHx surface to Cu facilitates initial C–N coupling while H* spillover from PdHx lattice to Cu promotes C–N intermediate protonation.

Macrophages play an important role in repair and regeneration of damaged nerves in spinal cord injury (SCI). Here, Guo et al. investigate effects of endoplasmic reticulum-mitochondria crosstalk on macrophage phenotype and develop a targeted nanorobot inhibiting the Ero1α/MAMs/mtCa²⁺ axis, promoting M2 polarization and neural repair as a therapeutic strategy to treat SCI.

Electrochemical CO reduction to multi-carbon products offers a carbon-negative approach to produce chemicals, but the intricate reaction pathways lead to a broad spectrum of products. Now it has been shown that alkali cations alter the mechanistic pathways that govern the reaction selectivity involved in the formation of hydrocarbons versus oxygenates.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

An amino-acid-encoded assembly strategy is developed for the synthesis of programmable chiral Solomon links, featuring tunable cavity dimensions and shapes. This template-free synthetic approach favours homochiral assembly over non-chiral or heterochiral pathways. The resulting interlocked molecules exhibit strong chiral amplification and exceptional enantioselective peptide recognition.

Aperiodic composite crystals were discovered that emulate 2D moiré materials, demonstrating a potentially scalable approach for producing moiré materials for next-generation electronics and a generalizable approach for realizing theoretical predictions of higher-dimensional quantum phenomena.

How small-bodied hominins in southeast Asia became so small ~60 thousand years ago is unclear. Here, the authors present hominin remains dated to 700 thousand years ago with even smaller body size, suggesting early evolution and maintained small size in the region.’

Prostate cancer incidence and mortality rates vary across males from diverse populations. Here, the authors perform a proteome-wide association study across different populations and establish population-specific genetic prediction models.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

By combining satellite observations with ground-based data and expert validation, this analysis demonstrates considerable misestimation of grassland extent and thereby carbon stock estimates in previous global assessments based on remote sensing.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Microbial decomposition of plant litter initially increases the molecular diversity of dissolved organic matter, but prolonged microbial recycling diminishes this diversity, highlighting how microbial metabolism influences soil carbon turnover.

Authors develop MuPPE, which enables integrated proteome, phosphoproteome, and glycoproteome profiling from a single sample, providing deeper biological insights into aging and drug-response mechanisms.

Single iron atoms on nitrogen-doped carbon catalysts are a promising alternative to platinum for the oxygen reduction reaction on fuel cell cathodes, but commonly suffer from low stability. Here an in situ chemical vapour deposition synthetic approach is presented, enabling high iron active site dispersion and reducing surface porosity, which mitigates demetallation and carbon corrosion, ensuring high activity and stability.

MedHELM, an extensible evaluation framework including a new taxonomy for classifying medical tasks and a benchmark of many datasets across these categories, enables the evaluation of large language models on real-world clinical tasks.

This study uses single-nucleus RNA sequencing to analyze lung tissue from 141 individuals with chronic obstructive pulmonary disease. Distinct patterns of spatially resolved changes in cell composition and cell states that correlate with clinical features are highlighted.

Two main acceleration mechanisms in the auroral acceleration region are electric potential and Alfvénic acceleration but associated energy dynamics are not completely resolved. Here, the authors show that Alfvén waves power the Earth’s auroral arc through a static potential drop in the auroral acceleration region.

Stylistic similarities of stone tools recovered from 800,000-year-old deposits in Flores with stone tools associated with the much later Homo floresiensis suggest continuity — calling into question claims that the brain of Homo floresiensis was too small to have accommodated technology.

CRISPR-Cas9 technology holds the potential to treat a wide spectrum of genetic diseases. Here, the authors describe a modular platform for extracellular vesicle-based Cas9 delivery, using MS2-based RNA-binding domains and UV-cleavable linkers, suitable for various Cas9-based moieties.

Here the authors show that mitochondrial RNA leaks into the cytosol of senescent cells through sublethal apoptosis, driving inflammation. Blocking this pathway improves outcomes in Metabolic Dysfunction-Associated Steatohepatitis.

Therapeutic suppressor tRNAs are engineered to broaden their target range in vivo.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Currently, there is a lack of clear understanding on how glioma cells exploit neural electrophysiological signaling to drive hyper-invasive behavior. Here, the authors integrate custom microfluidics with machine learning-based signal decoding to uncover a mechanism by which tumors actively reprogram neural firing patterns, synchronizing with their microenvironment to enhance invasiveness.

Foundation models have significantly advanced computational pathology, but still face important challenges, particularly when integrating multimodal data. Here, the authors develop mSTAR, an approach that allows injecting multimodal, whole-slide context into pathology foundation models, improving performance in clinical and molecular tasks in oncology.

By integrating a ribo-seq dataset of 195 individuals with RNA-seq and proteomics data from the same cohort, researchers found prevalent post-transcriptional attenuation of eQTL effects and identified omic-specific QTLs associated with schizophrenia.

Variants in NOS1AP can cause monogenic nephrotic syndrome. Here, the authors show that disrupting the intergenic NOS1AP splice isoform that is more prevalent in podocytes leads to monogenic kidney disease responsive to RAAS inhibition.

Peanut is an important oil and protein crop. Here, the authors presents a population-specific pangenome for the PeanutMAGIC multiparent population and identify a third recessive AhFAD2C gene that can independently segregate and influence oleic acid content in peanut.

Measurements of carbon fluxes and wood phenology are used to assess carbon sources from photosynthesis and their sink into woody growth along a thermal gradient. The authors show that stem growth advances slower than photosynthesis per degree Celsius, creating a phenological mismatch for carbon.

A combination of high-resolution spatial imaging, spatial proteomics and transcriptional data reveals sparse and heterogeneous bacterial signals in gliomas and brain metastases.

GATA2 deficiency is one of the major causes of hereditary pediatric myelodysplastic neoplasms (MDS). Using iPSC-based models, this work recapitulates stepwise mutational trajectories in GATA2-related MDS and reveals their impact on myeloid differentiation.

Despite recent advances with trappedion-based platforms, achieving quantum networks with link efficiency greater than unity on metropolitan scales is still a challenge. Here, the authors demonstrate a multiplexed quantum network generating heralded entanglement at a rate faster than local decoherence.

Ferroptotic propagation aggravates kidney ischemia-reperfusion injury and causes delayed graft function. Here, the authors show that inhibiting lactate shuttle and AARS1-mediated NPM1 lactylation protects graft function by blocking ferroptotic waves.

Optoelectronic synapses are crucial for advanced visual systems but are hindered by limited storage memory. Here, the authors propose organic photoelectrochemical transistor array capable of multi-level memories for neuromorphic visual computing.

While nitrogen (N) and phosphorus (P) cycles have been investigated separately, the links between them are key for sustainable food systems. Combining material flow and ecological network analysis, this study examines the resilience of China’s N–P-coupled cycling network over time under different scenarios.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

The role of mosquito saliva proteins in viral infection remains incompletely understood. Here, the authors show that sialokinin facilitates viral dissemination while suppressing immune response and inflammation in chikungunya virus-infected mice.

Crop diversification is a promising strategy to enhance global food security, yet potential trade-offs between yields and nutritional outcomes remain unclear. This global synthesis reveals that transitioning from monoculture to crop rotation consistently boosts total yield, nutritional quality, and revenue by 14–27%, with win-win outcomes significantly outweighing trade-offs across major agricultural regions.

Cryogenic conditions limit molecular diffusion, inhibiting self-healing in most molecular systems. Here the authors present an organic molecular crystal capable of autonomous recovery at 77 K due to strong dipole–dipole interactions between aligned molecular layers.

mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.