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This study demonstrates a low-energy photon device based on the kagome metal RbV₃Sb₅. It demonstrates that Fermi surface reconstruction, driven by a phase transition, leads to the emergence of van Hove singularities near the Fermi level.

NiPS₃ is a van der Waals antiferromagnetic semiconductor where the exciton formation is strongly influenced by the magnetic ordering. Previous studies have been limited to magneto-optical approaches, but here, Lebedev, Gish and coauthors succeed in making field effect transistors that operate below the Néel temperature and observe an ultranarrow electroluminescence with a high degree of linear polarization.

Here the authors report an allotrope to the nanocarbon family, Graphene-P-phenyl-Graphene, for potassium-ion batteries.

Aperiodic composite crystals were discovered that emulate 2D moiré materials, demonstrating a potentially scalable approach for producing moiré materials for next-generation electronics and a generalizable approach for realizing theoretical predictions of higher-dimensional quantum phenomena.

Spectroscopic observations of the ultra-hot Jupiter WASP-189b reveal both volatile (H₂O, CO, OH) and refractory (Fe, Mg, Si) gas in its atmosphere. Here, the authors show that the abundance ratio of refractory species reflects that of the host star.

This study shows that mithramycin suppresses the EWS::FLI1 transcription factor in Ewing sarcoma using a hybrid CUT, Tag & GRO assay, revealing mechanism, need for continuous dosing, and supporting clinical use of next-gen analog AIT-102.

Control magnetic order with electric fields is of critical importance for spintronic devices, however, for certain material classes, such as van der Waals magnets, it is challenging. Here, Huang et al propose a spin-electric potential arising from polar spin interactions between differing constituent van der Waals magnets, which enables the electric field switching of spin orders.

Brief ultrasound to human frontal eye fields, but not motor cortex, rapidly biases eye movement contralaterally in a perceptual choice task. The size of this effect scales with individual baseline FEF inhibitory tone.

The 2D van der Waals ferromagnet Fe3GaTe2 supports highly efficient current induced domain wall motion with very high domain wall speed and mobility with an ultra-low threshold current density, likely due to its structural perfection.

The authors realize two- and three-site Kitaev chains in semiconducting quantum dots coupled via superconductors and tune them to the sweet spot where zero-energy Majorana modes appear at the chain ends. To assess Majorana localization, they couple the system to an additional quantum dot.

The authors synthesize rock-salt-structured LiMnSbTe₃, in which Sb₂Te₃-type van der Waals-like gaps are embedded as ordered local structures that both scatter phonons and enhance charge-carrier transport.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

The authors design a Pt/CuInP₂S₆/graphene heterostructure that achieves polarity-switchable photovoltaic current modulated by ferroelectric polarization. This enables programmable in-sensor computing, achieving high-performance visual tasks.

Therapy to allergy often targets a specific allergen without addressing cross-reactivity. Here the authors develop a consensus, cross-reactive allergen, use mRNA-lipid nanoparticle immunization to induce specific, neutralizing IgG responses, but find no therapeutic effects in mouse allergy models, hinting the need for further optimization prior to translation.

In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their progenitors in the bone marrow.

Biocatalysis of the chemotherapy drug, doxorubicin, relies on the cytochrome P450 DoxA, which is inefficient. Here, the authors ameliorated the biosynthetic limitations by identifying DoxA redox partners and DnrV, which prevents product inhibition, helping improve microbial production.

A molecular-level understanding of structural evolution upon electrochemical doping in organic mixed ionic-electronic conductors is required. A pronounced reduction in mass and thickness is observed in an n-type ladder polymer upon doping with protic cations owing to water expulsion.

Succinate metabolism is reported to be involved in acute myeloid leukemia (AML) tumorigenesis. Here, the authors demonstrate that succinate receptor 1 (Sucnr1) restricts hematopoiesis via regulation of S100A9, counterbalancing the Sucnr1-independent tumorigenic effect of succinate in AML.

Structural variants are an underexplored source of genetic diversity. Here, the authors use phased pangenome graphs to improve detection of these variants in dairy cattle and link these variants to traits of economic importance.

Many vascular‑disease risk loci lack defined causal genes. Here, the authors integrate functional genomics and CRISPR screens to identify genes influencing smooth muscle cell behaviour, validating roles for FES, BCAR1, CARF and SMARCA4, with Fes loss promoting atherosclerosis and hypertension.

Several transmission-blocking vaccine candidates based on Pfs230 and Pfs48/45 are in clinical development, but it remains unclear whether they will demonstrate high efficacy. Here, the authors develop a stabilized chimeric antigen presenting potent epitopes from Pfs230 and Pfs48/45 in a single construct and demonstrate induction of transmission-reducing antibodies when female mice are immunized with the antigen in a self-assembling protein nanoparticle formulation.

Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

In this work, researchers build a scalable photonic Chern insulator by twisting a fibre during fabrication, breaking an effective time-reversal symmetry and inducing a pseudo-magnetic field. The team reveals a ‘Goldilocks’ regime that guarantees topological protection against fabrication-induced disorder of any symmetry class in the fibre cross-section.

Here, the authors show that van der Waals isotopic heterostructures based on few-layer h¹⁰BN and h¹¹BN can be tuned to modulate the energy-momentum dispersions of hyperbolic phonon polaritons, offering an alternative approach to engineer the nanophotonic properties of 2D materials.

Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism underlying genetic risk for these disorders.

In this work, the researchers realize the current-induced motion of Néel type chiral domain walls via spin-transfer-torque in the pristine van der Waals ferromagnet Fe₃GeTe₂ and via spin-orbit-torques in heterostructures with platinum or tungsten.

A measurement strategy is described that is able to read out the parity of minimal two-site Kitaev chains in real time, by coupling two Majoranas and resolving their quantum capacitance.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

A distinctive population with high hunter-gatherer ancestry persisted 3,000 years later than in most European regions, contributing to later Lower Rhine–Meuse Bell Beaker users.

Weyl semimetals with low crystal symmetry, such as TaIrTe4, are known to host large unconventional spin-orbit torques. Here, Pandey et al combine TaIrTe4 with the van der Waals ferromagnet, Fe3GaTe2, and achieve room temperature field-free magnetization switching with an extremely low critical current density.

Five-year survival data and biomarker analysis of the PRADO extension cohort of the phase 2 OpACIN-neo trial, in which patients with high-risk stage III melanoma received neoadjuvant ipilimumab and nivolumab and underwent pathologic response-directed surgery and adjuvant therapy, show 71% event-free survival and 88% overall survival, with tumor mutational burden, IFNγ signature and PD-L1 expression associated with favorable outcomes.

A systematic review including 574 studies extracts information about transmissibility, epidemiological delays and outbreaks for Zika virus disease at global scale.

Terahertz microspectroscopic imaging at subgap millielectronvolt energies of a two-dimensional superfluid plasmon in few-layer Bi₂Sr₂CaCu₂O_8+x is demonstrated, allowing the spatial resolution of its deeply subdiffractive terahertz electrodynamics.

The current unbalance between the performance of n-type and p-type 2D transistors limits their applications for next-generation electronics. Here, the authors report the realization of high-performance 2D MoTe₂ p-type transistors by depositing metallic tellurium contacts via thermal evaporation.

Extending their previous findings of brain changes in a first pregnancy, the authors show that a second pregnancy uniquely alters women’s brains, involving both a further fine-tuning of first-pregnancy effects and distinct changes in other networks.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Preclinical studies indicate a synergistic effect of radiotherapy treatment (RT) and Immune checkpoint inhibitors (ICI) on tumor growth and metastasis. However, little is known about the immunomodulatory performance of different radioisotopes on the tumor microenvironment. Here, the authors employ alpha- versus beta-particle emitting radiopharmaceuticals in combination with dual ICI therapy and dissect mechanisms of in vivo immunomodulation and timing of ICI administration relative to RT, by comparing responses in immunogenic and non-immunogenic preclinical mouse models.

Fracture behaviours in multilayer h-BN, involving interlayer-friction toughening and edge-reconstruction embrittlement, are identified through in situ experiments and theoretical analyses.

An approach to discover reactive diazo-based metabolites by capture based on their reactivity coupled to mass spectrometry revealed two previously unknown diazo-containing compounds produced by the human lung pathogen Nocardia ninae using novel biosynthetic chemistry.

A platinum(II) azido complex (complex 1) that releases platinonitrene upon X-ray exposure induces DNA damage and enhances immune checkpoint blockade outcomes via the abscopal effect.

This paper uses multiomics to profile a large cohort of meningioma samples to highlight the role of the tumor microenvironment in driving the epigenetic changes underpinning tumor classification and prediction of outcome.

Many-body van-der-Waals interaction in multilayer structures has long been predicted but is difficult to be observed experimentally. Here the authors verify it in a tip graphene-substrate system benefiting from atomically thin intermediate graphene.

Nonlinear optical phonons often exhibit rapid decay. Here, the authors demonstrate long-lived nonlinear optical phonons through the spontaneous formation of phonon frequency combs in CrXTe₃ (X=Ge,Si).

It is unclear whether the harsh abiotic conditions of drylands hinder biological invasions. This global analysis shows that drylands are vulnerable to non-native plants and are likely to become more so as native plant diversity declines and grazing pressure intensifies.

Each valley of the mini-Brillouin zone ("mini valley") of twisted bilayer graphene (TBG) contains two Dirac cones that hybridize to form flat bands. Theory predicts that these two Dirac cones have the same chirality, leading to topological obstruction. Here, the authors confirm this prediction experimentally.

CFAP20 has a key role in rescuing RNA polymerase II complexes that have arrested during DNA transcription, limiting the accumulation of R-loops and preventing collisions between the transcription and replication machinery.

An optical method images nonlinear optical processes in waveguides with femtosecond and nanometre precision. The approach is used to achieve phase-matched second-harmonic generation in 3R-MoS₂ waveguides.