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This study demonstrates how to combine molecular dynamics computer simulations with experimental biophysical data to determine accurate atomic-resolution ensembles of intrinsically disordered proteins.

A brain–heart–eye axis is generated through integration of multi-omics and multi-organ data from UKBB, BLSA, FinnGen and PGC, revealing phenotypic landscapes and genetic arcitectures of disease.

Rapid discovery of functional resistance genes is enabled by a high-expression signature and high-throughput transformation. This approach identified 31 new resistance genes for wheat and can be applied across crops to support food security.

Large language models can describe and classify changing objects in astronomical images with high accuracy. This enables searches for visual features using text and introduces a new way to interact with sky survey data.

The authors conduct a national inventory on individual tree carbon stocks in Rwanda using aerial imagery and deep learning. Most mapped trees are located in farmlands; new methods allow partitioning to any landscape categories, effective planning and optimization of carbon sequestration and the economic benefits of trees.

Reducing non-radiative recombination at the perovskite/electron transport layer interface remains a critical challenge for achieving efficient perovskite/TOPCon silicon tandem solar cells. Here, authors employ bilayer passivation using AlOx/PDAI2 treatment, achieving device efficiency of 31.6%.

Two-qubit operations exceeding 99% fidelity have been demonstrated by silicon devices made with standard semiconductor tooling in a 300-mm foundry environment.

Using an advanced imaging system called EyeRIS, locomotion in deep-sea octopuses could be studied, revealing simplified crawling patterns that could inspire the design of robots.

Adding Strongyloides stercoralis diagnostics to Rwanda’s soil-transmitted helminth control program was evaluated. Following training, Baermann and stool culture tests were implemented successfully, with no reported issues with rapid testing.

Quantum sensors based on NV centers in diamond can reach sub-nanometer spatial resolution, but high temporal resolution remains a challenge. Here the authors report an ultrafast electro-optical sensor using NV centers, demonstrating surface electric field sensing with nanometer–femtosecond resolution.

A 165 Myr record of N and Corg isotopes show that the N-cycle responds to feedbacks associated with productivity and the location of upwelling centers changing due to continental meander.

Nutrient-induced soil carbon gains in grasslands can persist for decades after fertilization stops as long as the soil remains untilled, according to a multidecadal field experiment on retired agricultural fields with sandy soils.

Measuring selection and dominance in fitness of the insecticide-resistant Ace alleles in Drosophila melanogaster, the authors show evidence for beneficial reversal of dominance, a mechanism that can stabilize large-effect polymorphisms in nature.

2023 CX1 is the only L-chondrite-like asteroid analysed from space to ground. It catastrophically fragmented in the atmosphere, depositing 98% of its energy in one burst—an unusual, high-risk fragmentation mode with implications for planetary defence.

A purpose-built implantable system based on biomimetic epidural electrical stimulation of the spinal cord reduces the severity of hypotensive complications in people with spinal cord injury and improves quality of life.

Two bead-based approaches for CRISPR diagnostics increase sensitivity and deployability in resource-constrained settings.

This study examines the outcomes of dietary shifts across intrinsic and instrumental conservation perspectives, finding that most conservation benefits already come from a partial shift to healthier, more plant-based diets, whereas greater benefits depend on more targeted conservation action.

Here, the authors present archaeological excavations from two sites paired with life-size rock engravings from 12,800 to 11,400 years ago in the Nefud desert of northern Arabia. These engravings, depicting camels, ibex and more, combined with stone tools from associated archaeological deposits and sediment analyses of playa deposits, provide evidence of human populations exploiting seasonal waterbodies.

The axial Higgs mode is theoretically attributed to a hidden ferroaxial component of charge order. In rare-earth tritellurides, this ferroaxial order is now shown to be induced by intertwined orbital and charge orders.

Tau aggregation, a hallmark of Alzheimer’s disease, disrupts neuron structure. Aging weakens chaperone defenses like Hsp90. This study designs β-Hsp90, a small peptide mimicking Hsp90, to prevent Tau aggregation, offering promise for new amyloid disease drugs.

RNA base editing represents an exciting modality in precision genetic medicine. Here the authors develop short, metabolically stable RNA oligonucleotides (RESTORE 2.0) that enable precise and efficient RNA base editing, demonstrating successful in-vivo correction of a disease-causing human mutation.

Head and neck squamous cell carcinoma (HNSCC) frequency and risk factors vary considerably across regions and ancestries. Here, the authors conduct a multi-ancestry genome-wide association study and fine mapping study of HNSCC subsites in cohorts from multiple continents, finding susceptibility and protective loci, gene-environment interactions, and gene variants related to immune response.

In a magnetoelectric material, an applied electric field can drive changes in the magnetic order. This feature has profound technology prospects and here, Moody et al demonstrate deterministic control of the direction of magnetic spiral order via an applied electric field in Cu₂OSeO₃.

A complementary analysis of DESI DR2 distance measurements along with supernova and CMB data shows consistent, moderate evidence that dark energy changes over time rather than behaving as a simple cosmological constant.

Recent work has expanded the concept of altermagnets to non-collinear magnetic materials. Here, Hu et al extend this further to non-collinear chiral materials, determining altermagnetic multipolar order parameters and predicting that such materials host large spin-hall and Edelstein effects.

Biomolecular condensates (BCs) are ubiquitous compartments that regulate key functions in cells. Authors demonstrate that phase separation is suppressed with glycine by using model heterotypic condensates composed of nucleophosmin 1 and ribosomal ribonucleic acid.

Chapman, Klaourakis and colleagues reveal that a lymphatic vasculature with poor clearance capacity in perinatal, regeneration-competent mouse hearts is required to retain pro-reparative macrophages and allow cardiac regeneration.

Chemist who launched the study of caged hydrocarbons.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

In three dimensions, it is possible to have more complicated spin textures, one such example is a hybrid chiral skyrmion tube, where each end of the tube has skyrmions of opposite chirality. Here, Dohi, Bhukta, Kammerbauer and coauthors find that these skyrmion tubes exhibit a non-reciprocal skyrmion Hall effect.

Mothers can fiercely defend their young, but how the brain triggers this response remains to a large extent a mystery. Here, authors show that a dormant, hormone-sensitive brain circuit switches on to spark maternal aggression during the lactation period.

In this study, Yang et al. compile a global dataset to uncover the degree to which plants coordinate root and seed traits. They report a global positive correlation between root diameter and seed size, driven by dual roles of arbuscular mycorrhiza in phosphorus uptake and pathogen defence.

A year-long experiment in a wet tropical forest found that 4 ^oC of warming boosted soil CO₂ emissions by 42-204%. These high rates suggest tropical soils may release more carbon under future warming than climate models predict.

The accrual of soil carbon from absorptive fine roots exceeds that of leaf litter in forests despite lower productivity, according to an analysis of field observations from Northern Hemisphere forest sites.

This study reports age-dependent negative correlations between temporal changes in maximal leaf area index and growing season length, indicating contrasting leaf acclimation strategies driving vegetation greening in young versus old deciduous broadleaf forests.

The systemic discovery of metal–small-molecule complexes from biological samples is a difficult challenge. Now, a method based on liquid chromatography and native electrospray ionization mass spectrometry has been developed. The approach uses post-column pH adjustment and metal infusion combined with ion identity molecular networking, and a rule-based informatics workflow, to interrogate small-molecule–metal binding.

The microbiomes associated with reef corals are complex and diverse. Here, the authors investigate fire coral clones naturally occurring in distinct habitats as a model system to disentangle the contribution of host genotype and environment on their microbiome, and predict genomic functions based on taxonomic profiles.

Recently, an orbital Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) state was predicted and identified in thin flakes of the transition metal dichalcogenide superconductor 2H-NbSe₂. Here, the authors present experimental evidence of the formation of this orbital FFLO state in bulk 2H-NbSe₂ samples.

There is no consensus on a potential primary cause of spatio-temporal biodiversity patterns. Here the authors combine a macroecological model and global climate simulations to suggest that niche-environment interaction may have driven marine biodiversity trajectory during the Phanerozoic.

A new form of momentum-selective electron energy-loss spectroscopy enables the element-resolved imaging of frequency- and symmetry-dependent vibrational anisotropies with atomic resolution.

Nitrogen and phosphorus limitations are both key to spatial patterns and temporal trends in primary production. This global analysis indicates that phosphorus limitation on terrestrial primary productivity has become stronger and is increasing more rapidly than nitrogen limitation.

Opposing forces generated by exopolysaccharide trail binding versus type IV pilus retraction generate a high cyclic diGMP–high cyclic AMP state in Pseudomonas aeruginosa that promotes social motility.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Leveraging in-memory computing with emerging gain-cell devices, the authors accelerate attention—a core mechanism in large language models. They train a 1.5-billion-parameter model, achieving up to a 70,000-fold reduction in energy consumption and a 100-fold speed-up compared with GPUs.

GTPase-activating proteins (GAPs) often contain regulatory PH domains. In this work, Soubias et al, using an integrated structure-function approach, discovered a mechanism where a GAP PH domain binds directly to a GTPase to induce allosteric changes facilitating GTP hydrolysis.

In vivo chimeric antigen receptor (CAR)-T cell engineering uses targeted delivery systems to generate CAR-T cells directly in patients, bypassing ex vivo manufacturing. This Review examines emerging viral and lipid nanoparticle platforms, early clinical proof of concept and potential applications beyond cancer.

A retrospective, observational study shows that completion of a diabetes prevention program in England (the NHS Diabetes Prevention Programme) was associated with decreased incidence of type 2 diabetes and long-term conditions such as dementia and chronic obstructive pulmonary disease at 24 months.