Using rat and mouse models of pulmonary hypertension and patientsā data, Shu, Liu, Zhou et al. show that the concomitant increase in immunoglobulin E (IgE) and mast cells expressing the effector receptor FcĪµRIĪ± has an important role in pulmonary vascular remodeling, and genetic and pharmacological inhibition of the IgEāFcĪµRIĪ± signaling alleviated the progression of pulmonary hypertension in animal models.
- Ting Shu
- Ying Liu
- Chen Wang
