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Assessing renal risk in patients with type 2 diabetes

Accurate stratification of renal risk is important for the effective management of patients with type 2 diabetes. In a new study, Elley et al. report and validate a 5-year prediction model for the development of end-stage renal disease in patients with type 2 diabetes in primary care.

Merlin C. Thomas
Per-Henrik Groop
News & Views17 Sept 2013
Nature Reviews Nephrology

Volume: 9, P: 559-560
Screening for chronic kidney disease in patients with diabetes: are we missing the point?

Screening for chronic kidney disease in patients with diabetes should encompass not only testing for albuminuria, but also the subsequent diagnostic procedures and interventions. Otherwise, what is the purpose of testing? The authors of this Viewpoint highlight the inadequacies of current screening practices, and argue that detection of increased urinary albumin excretion in a patient with diabetes should be a call to action.

Merlin C Thomas
GianCarlo Viberti
Per-Henrik Groop
Reviews27 Nov 2007
Nature Clinical Practice Nephrology

Volume: 4, P: 2-3
Correction: Diabetic kidney disease

Merlin C. Thomas
Michael Brownlee
Mark E. Cooper
Amendments and Corrections29 Oct 2015
Nature Reviews Disease Primers

Volume: 1, P: 1
Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity

In obesity, mitochondrial communication with the nucleus may be disrupted. Here, the authors use Finnish twin data to link obesity-related changes in mitochondrial DNA quantity with the methylation and expression of SH3BP4 in adipose tissue.

Aino Heikkinen
Vivienne F. C. Esser
Miina Ollikainen
ResearchOpen Access12 May 2025
Nature Communications

Volume: 16, P: 1-14
Genetic factors affect the susceptibility to bacterial infections in diabetes

Johan R. Simonsen
Annemari Käräjämäki
Markku Lehto
ResearchOpen Access04 May 2021
Scientific Reports

Volume: 11, P: 1-11
Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes

Anni A. Antikainen
Jani K. Haukka
Niina Sandholm
ResearchOpen Access11 Jun 2024
Scientific Reports

Volume: 14, P: 1-16
Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function

Here, the authors identified genetic variants associated with urinary metabolites in 8,011 individuals. Further causal analysis suggested estimated kidney filtration rate (eGFR) affected 13 metabolites while ethanolamine was associated with higher eGFR.

Erkka Valo
Anne Richmond
Niina Sandholm
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Dietary intake and hospitalisation due to diabetic ketoacidosis and hypoglycaemia in individuals with type 1 diabetes

Aila J. Ahola
Valma Harjutsalo
Per-Henrik Groop
ResearchOpen Access15 Jan 2021
Scientific Reports

Volume: 11, P: 1-7
Meal timing, meal frequency, and breakfast skipping in adult individuals with type 1 diabetes – associations with glycaemic control

Aila J. Ahola
Stefan Mutter
Per-Henrik Groop
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
Mechanisms of Disease: pathway-selective insulin resistance and microvascular complications of diabetes

Diabetes and obesity are associated with pathway-selective insulin resistance in the phosphatidylinositol 3-kinase and CBL E3 ubiquitin protein ligase–(CBL)/CBL E3 ubiquitin protein ligase associated protein (CAP) signaling pathways, while insulin signaling via extracellular signal-regulated kinase (ERK) is comparatively unaffected, tipping the balance of insulin's actions so that they favor abnormal vasoreactivity, angiogenesis, and other pathways implicated in the development and progression of microvascular disease.

Per-Henrik Groop
Carol Forsblom
Merlin C Thomas
Reviews01 Dec 2005
Nature Clinical Practice Endocrinology & Metabolism

Volume: 1, P: 100-110
Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease

Approximately 40 percent of people with type 1 diabetes develop kidney disease, but the risk factors are not well understood. Here, the authors identify DNA methylation signatures associated with diabetic kidney disease, of which 21 biomarkers predict the development of kidney failure.

Laura J. Smyth
Emma H. Dahlström
Amy Jayne McKnight
ResearchOpen Access22 Dec 2022
Nature Communications

Volume: 13, P: 1-16
Detection of hydrogen cyanide from oral anaerobes by cavity ring down spectroscopy

Wen Chen
Kajsa Roslund
Markku Lehto
ResearchOpen Access04 Mar 2016
Scientific Reports

Volume: 6, P: 1-9
Endotoxins are associated with visceral fat mass in type 1 diabetes

Mariann I. Lassenius
Aila J. Ahola
Markku Lehto
ResearchOpen Access13 Dec 2016
Scientific Reports

Volume: 6, P: 1-6
Medication profiling in women with type 1 diabetes highlights the importance of adequate, guideline-based treatment in low-risk groups

Raija Lithovius
Stefan Mutter
Per-Henrik Groop
ResearchOpen Access19 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
Effect of serum sample storage temperature on metabolomic and proteomic biomarkers

Erkka Valo
Marco Colombo
R. Neil Dalton
ResearchOpen Access17 Mar 2022
Scientific Reports

Volume: 12, P: 1-10
The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes

Jakob Appel Østergaard
Fanny Jansson Sigfrids
Per-Henrik Groop
ResearchOpen Access26 Apr 2021
Scientific Reports

Volume: 11, P: 1-9
Waist-height ratio and waist are the best estimators of visceral fat in type 1 diabetes

Erika B. Parente
Stefan Mutter
Per-Henrik Groop
ResearchOpen Access29 Oct 2020
Scientific Reports

Volume: 10, P: 1-10
Metabolomic Profile Predicts Development of Microalbuminuria in Individuals with Type 1 Diabetes

Jani K. Haukka
Niina Sandholm
Ele Ferrannini
ResearchOpen Access14 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes

Niina Sandholm
Jani K Haukka
Per-Henrik Groop
ResearchOpen Access17 Aug 2018
Scientific Reports

Volume: 8, P: 1-8
Oxygen-induced impairment in arterial function is corrected by slow breathing in patients with type 1 diabetes

Luciano Bernardi
Daniel Gordin
Per-Henrik Groop
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity

Aila J Ahola
Mariann I. Lassenius
Per-Henrik Groop
ResearchOpen Access26 Jul 2017
Scientific Reports

Volume: 7, P: 1-9
Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

Ruchi Jain
Türküler Özgümüş
Valeriya Lyssenko
ResearchOpen Access14 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
High-throughput pedigree drawing

Ville-Petteri Mäkinen
Maija Parkkonen
Kimmo Kaski
Research04 May 2005
European Journal of Human Genetics

Volume: 13, P: 987-989
Diabetic kidney disease

Diabetic kidney disease is caused by microvascular damage sustained as a result of diabetes. Cooper et al. discuss current knowledge on this condition, arguing that novel strategies to halt and reverse disease progression are urgently needed.

Merlin C. Thomas
Michael Brownlee
Mark E. Cooper
Reviews30 Jul 2015
Nature Reviews Disease Primers

Volume: 1, P: 1-20
Antibiotic treatment and supplemental hemin availability affect the volatile organic compounds produced by P. gingivalis in vitro

Kajsa Roslund
Moona Uosukainen
Markus Metsälä
ResearchOpen Access29 Dec 2022
Scientific Reports

Volume: 12, P: 1-11
Faecal biomarkers in type 1 diabetes with and without diabetic nephropathy

Signe Abitz Winther
Miia Maininki Mannerla
Peter Rossing
ResearchOpen Access26 Jul 2021
Scientific Reports

Volume: 11, P: 1-11
Identifying volatile in vitro biomarkers for oral bacteria with proton-transfer-reaction mass spectrometry and gas chromatography–mass spectrometry

Kajsa Roslund
Markku Lehto
Markus Metsälä
ResearchOpen Access19 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Cyclin-dependent kinase 2 protects podocytes from apoptosis

Pauliina Saurus
Sara Kuusela
Sanna Lehtonen
ResearchOpen Access15 Feb 2016
Scientific Reports

Volume: 6, P: 1-14

Search

Assessing renal risk in patients with type 2 diabetes

Screening for chronic kidney disease in patients with diabetes: are we missing the point?

Correction: Diabetic kidney disease

Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity

Genetic factors affect the susceptibility to bacterial infections in diabetes

Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes

Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function

Dietary intake and hospitalisation due to diabetic ketoacidosis and hypoglycaemia in individuals with type 1 diabetes

Meal timing, meal frequency, and breakfast skipping in adult individuals with type 1 diabetes – associations with glycaemic control

Mechanisms of Disease: pathway-selective insulin resistance and microvascular complications of diabetes

Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease

Detection of hydrogen cyanide from oral anaerobes by cavity ring down spectroscopy

Endotoxins are associated with visceral fat mass in type 1 diabetes

Medication profiling in women with type 1 diabetes highlights the importance of adequate, guideline-based treatment in low-risk groups

Effect of serum sample storage temperature on metabolomic and proteomic biomarkers

The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes

Waist-height ratio and waist are the best estimators of visceral fat in type 1 diabetes

Metabolomic Profile Predicts Development of Microalbuminuria in Individuals with Type 1 Diabetes

Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes

Oxygen-induced impairment in arterial function is corrected by slow breathing in patients with type 1 diabetes

Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity

Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

High-throughput pedigree drawing

Diabetic kidney disease

Antibiotic treatment and supplemental hemin availability affect the volatile organic compounds produced by P. gingivalis in vitro

Faecal biomarkers in type 1 diabetes with and without diabetic nephropathy

Identifying volatile in vitro biomarkers for oral bacteria with proton-transfer-reaction mass spectrometry and gas chromatography–mass spectrometry

Cyclin-dependent kinase 2 protects podocytes from apoptosis

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