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Ferromagnetic van der Waals contacts of indium and cobalt can provide robust and reproducible spin injection in graphene lateral spin valves without the need for an additional dielectric tunnel barrier.

A multitrait fine-mapping method, mvSuSiE, improves power and resolution over single-trait methods for identifying putative causal variants from genetic association data.

Amorphous films with tunable thermal conductivity are needed for semiconductor/aerospace fields. Amorphous Al(Ti)N nanoparticles have negligible effect on thermal conductivity of Si₃N₄ 2 W m⁻¹K⁻¹, while incorporating crystal TiN phases increases to 15 W m⁻¹K⁻¹.

The authors employ a 3D printing technique to induce a triple-twinned martensitic microstructure in a commercial titanium alloy, achieving both high strength and enhanced strain hardening.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

How prioritization affects the format of visual working memory representations is currently not understood. Analyzing iEEG recordings in epilepsy patients, the authors demonstrate the critical role of recurrent computations and beta frequency oscillations during the selective attention to particular visual working memory content in the PFC.

Standardisation of working with 3D cell cultures in high-content screening (HCS) approaches remains difficult. Here, the authors propose HCS-3DX, a system for HCS of 3D tumour models at single-cell resolution by combining micromanipulation, custom multi-well plates, advanced imaging and AI-based analysis.

Injectable conductive hydrogels offer a promising alternative for tumor electrotherapy. Here, the authors develop highly conductive injectable bioresorbable soft electrode that enable minimally invasive glioblastoma electroimmunotherapy, achieving tumor ablation and robust immune activation.

Medication non-adherence represents a healthcare challenge, generating over $100 billion in additional costs annually in the USA. Here, the authors developed a resorbable and ingestible system designed for assessing medication adherence.

Figure 1. Schematic illustration of capsule based, biodegradable medication adherence tracking system with envisioned scenario for clinical use. A, Bio-RFID capsule administration. B, Shielding coating dissolution and payload release C, Monitoring of the Tag ID and frequency range, recording of the payload for tracking adherence. D, Dissolution and biosorption of the coating, tag and the capsule.

Biosynthesis of all androgens from cholesterol first requires cytochrome P450 (CYP) 11A1 for generation of pregnanes and then CYP17A1 for biosynthesis of androgens, but CYP17A1 inhibition cannot completely inhibit androgen biosynthesis in prostate cancer. Here, the authors identify a role for CYP51A1 in the biosynthesis of androgens that completely bypasses the requirement for CYP17A1 and demonstrate that CYP51A1 is essential for the biosynthesis of ¹³C-testosterone from ¹³C-cholesterol in prostate cancer cells.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Microhomology-mediated end joining (MMEJ) and mitotic DNA synthesis (MiDAS) are critical DNA repair pathways in mitosis. Here the authors show that CIP2A–TOPBP1 coordinate mitotic DNA repair through the regulation of factors required for MiDAS and MMEJ.

Stem-cell-derived islet cells could transform type 1 diabetes by removing the need for injected or infused insulin and improving quality of life. But evaluation of these therapies must center on the voices of people living with type 1 diabetes and examine meaningful outcomes.

As presented at the American Heart Association Conference 2025, patients with chest pain and without obstructive coronary artery disease benefit from treatment informed by cardiovascular magnetic resonance.

Inspired by dynamic textural modulation in cephalopod skin, polymer films whose colour and surface texture can be dynamically and independently controlled are developed and demonstrated using standard electron-beam patterning tools.

The Fair Human-Centric Image Benchmark (FHIBE, pronounced ‘Feebee’)—an image dataset that implements best practices for consent, privacy, compensation, safety, diversity and utility—can be used responsibly as a fairness evaluation dataset for many human-centric computer vision applications.

Geminin regulates DNA replication by binding CDT1 and preventing MCM helicase loading. Using a reconstituted system and structural modelling, the authors find geminin inhibits via steric clash with MCM, not by blocking the CDT1–MCM interface. Combined with CDK activity, it fully halts licensing.

Vaginal birth, exclusive breastfeeding and early contact with siblings promote colonization of the infant gut with bifidobacteria capable of producing aromatic lactates, a microbial and metabolite signal that is inversely related to the risk of allergen-specific sensitization and dermatitis later in life.

u-Segment3D is a universal framework that translates and enhances 2D instance segmentations to a 3D consensus instance segmentation without training data. It performs well across diverse datasets, including cells with complex morphologies.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

This study shows how the links between somatic passenger mutations in tumors and normal cell transcriptomes can be used to infer cell-of-origin in lung adenocarcinoma.

The authors present Gemini, their bifunctional replicon platform capable of functioning as either self-amplifying RNA (saRNA) or self-amplifying DNA (saDNA).

The authors show that babies conceived during the COVID-19 pandemic have a different parental socioeconomic composition than expected had the pandemic not occurred.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Ferritin controls iron concentrations by storing Fe(III), but the mechanism by which Fe(II) is bound and trafficked into the protein core after oxidation remains controversial. Spectroscopic methods in combination with labeling and competition assays now define a mechanism conserved from archaea to humans.

Here, the authors show that methylphenidate alters brain organization by compressing the hierarchy between sensory and association areas. This dopamine-driven shift predicts improved attention, revealing how stimulants reorganize brain networks to enhance cognitive function.

ADPKD is a genetic kidney disease caused by mutations in PKD1. Here, the authors develop broadly expressed and kidney specific promoter mediated adenine base editors to correct point mutation of Pkd1 gene, rescuing pathology in a humanized mouse model.

Structure-specific endonucleases play an important role in several DNA repair pathways. Here the authors present structures of the endonuclease XPF-ERCC1 in complex with SLX4, SLX4IP, and DNA. Combined with functional analysis, these results provide insight into the mechanisms of XPF-ERCC1 recruitment and activation during DNA repair.

The nature of the ferryl intermediate generated in reactions catalysed by heme-containing enzymes is uncertain, due to the ambiguity of X-ray crystallography data. Here, the authors apply neutron diffraction, kinetics and other spectroscopy to directly observe a protonated ferryl intermediate in a heme peroxidase.

An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney transplant patients.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

During SARS-CoV-2 infection caspase-8 fuels harmful inflammation independent of apoptosis. Genetic loss of caspase-8 reduces cytokine levels, lowers viral load and mitigates disease severity, revealing non-apoptotic caspase-8 as a key driver of severe COVID-19.

Multidrug-resistant (MDR) bacteria are a global health problem. In this work, the authors report an antimicrobial polymer that crosses the bacterial membrane and phase separates with intracellular nucleic acids, demonstrating efficacy against MDR bacteria in various murine models.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

The NeoRHEA trial showed that treatment with palbociclib and endocrine therapy decreases T cell proliferation and the presence of tissue-resident memory T cells. These results are important for the development of CDK4 selective inhibitors.

A pangenome of oat, assembled from 33 wild and domesticated oat lines, sheds light on the evolution and genetic diversity of this cereal crop and will aid genomics-assisted breeding to improve productivity and sustainability.

Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.

Photonic processors are limited by the bulkiness of discrete components and wiring complexity. An experiment now demonstrates a reprogrammable two-dimensional waveguide that performs neural network inference through multimode wave propagation.

Termites, the largest lineage of non-hymenopteran social insects, are important decomposers of plant organic matter in the tropics. Here, the authors sequence the genomes of 45 termites and two cockroach outgroups and investigate the influence of diet on the evolution of termite genomes.

The alveolate alga Chromera velia is a close relative of parasitic apicomplexans that possesses an unusual Photosystem I. Here, the authors present the cryo-EM structure of this complex, revealing several novel subunits, including a bound superoxide-dismutase heterodimer.

Seawater corrosion can impact the lifespan and reliability of metallic materials for marine applications. This work develops a titanium alloy exhibiting active passivation behavior that ensures its electrochemical and mechanical stability in seawater-like environments.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Here Jaster et al., show a single psilocybin dose produce sex-specific post-acute changes in opioid reward and withdrawal via 5-HT2A receptors in frontal cortex-to–nucleus accumbens circuits, with epigenetic and synaptic changes shaping therapeutic potential.